Method for refining 4 ¿C (3,4 ¿C dichlorobenzene group) ¿C 1 ¿C tetralin ketone

Abstract

This invention discloses a method for refining 4-(3,4-dichlorophenyl)-1-tetralone. The method comprises: adding 4-(3,4-dichlorophenyl)-1-tetralone and solvent at a ratio of 1:(3-4) into a three-necked flask with a stirrer, heating under stirring until 4-(3,4-dichlorophenyl)-1-tetralone is completely dissolved, heating to 60-100 deg.C, refluxing for 0.5-2 h, cooling the filtrate to -5-10 deg.C, filtering, recrystallizing to obtain refined 4-(3,4-dichlorophenyl)-1-tetralone, and drying at 40-80 deg.C to obtain dry 4-(3,4-dichlorophenyl)-1-tetralone. The method has such advantages as high purity, short time, high yield, and stable product quality.

Description

Technical field:

[0001] The invention relates to a method for refining fine chemical and pharmaceutical intermediates, in particular to a method for refining 4-(3,4-dichlorophenyl)-1-tetralone. Background technique:

[0002] 4-(3,4-dichlorophenyl)-1-tetralone is also called 4-(3,4-dichlorophenyl)-3,4-dihydro-1-(2H)-naphthalenone, is Light yellow crystal, melting point 99℃~104℃, insoluble in water, easily soluble in organic solvents such as esters and aromatic compounds. It is an important intermediate in the synthesis of a large number of biological and pharmaceutical activities, especially for the synthesis of behavioral inhibitors with antidepressant effects. 4-(3,4-dichlorophenyl)-1-tetralone is an important intermediate in the synthesis of the new antidepressant sertraline hydrochloride, and sertraline hydrochloride accounts for 40% of the world antidepressant market.

[0003] As can be seen from the relevant domestic and foreign literatures currently available, there ...