Multiple responsive high molecular microcapsule and preparation method thereof
A multi-response, polymer technology, applied in the field of biomedical materials, can solve problems such as narrow application range, difficulty in embedding inorganic nanoparticles, and single function of polymer microcapsules
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Embodiment 1
[0031] This embodiment 1 is implemented under the following conditions of implementation and technical requirements:
[0032] (1) 0.2g molecular weight is the poly-L-lactic acid of 500,000 and 200mg Fe 3 o 4 Dissolve the magnetic nanoparticles in 20mL of chloroform; prepare 30mL of 0.5% (mass percentage concentration, the same below) polyvinyl alcohol aqueous solution for subsequent use;
[0033] (2) Inject 10 mL of double distilled water into the above mixed solution, and stir at 10000 rpm for 1 min to obtain a water-in-oil emulsion;
[0034](3) Inject the above-mentioned water-in-oil emulsion into the prepared aqueous polyvinyl alcohol solution (the volume ratio of the water-in-oil emulsion to the protective colloid solution is 1:1-1:10, the same below), and stir at 5000rpm for 5min, get a double emulsion;
[0035] (4) Mix 60ml of the above double emulsion with 60mL of water, and stir at 400rpm for 4h;
[0036] (5) The microcapsules were collected by centrifugation, wash...
Embodiment 2
[0039] This embodiment 2 is implemented under the following conditions of implementation and technical requirements:
[0040] (1) 2g molecular weight is 100,000 polycyclolactic acid and 100mg γ-Fe 2 o 3 Dissolve the magnetic nanoparticles in 20mL of dichloromethane; prepare 200mL of 2% polyvinyl alcohol aqueous solution for later use;
[0041] (2) Inject 2 mL of double distilled water into the above mixed solution, and stir at 15000 rpm for 2 min to obtain a water-in-oil emulsion;
[0042] (3) Inject the above water-in-oil emulsion into the prepared aqueous solution of polyvinyl alcohol, and stir at 10000rpm for 4min to obtain a double emulsion;
[0043] (4) Mix 220mL of the above double emulsion with 220mL of water, and stir at 800rpm for 6h;
[0044] (5) The microcapsules were collected by centrifugation, washed twice with distilled water and once with n-hexane, freeze-dried and filled with sulfur hexafluoride gas under negative pressure to obtain powdery microcapsules. ...
Embodiment 3
[0047] This embodiment 3 is implemented under the following conditions of implementation and technical requirements:
[0048] (1) Dissolving 0.5g of polylactide with a molecular weight of 350,000 and 150mg of CdSe nanocrystals in 20mL of chloroform; preparing 60mL of 1% gelatin aqueous solution for subsequent use;
[0049] (2) Inject 8 mL of double distilled water into the above mixed solution, and stir at 15000 rpm for 2 min to obtain a water-in-oil emulsion;
[0050] (3) Inject the above water-in-oil emulsion into the prepared aqueous gelatin solution, and stir at 10000rpm for 5min to obtain a double emulsion;
[0051] (4) Mix 90mL of the above double emulsion with 90mL of water, and stir at 800rpm for 2h;
[0052] (5) The microcapsules were collected by centrifugation, washed once with distilled water and twice with n-hexane, freeze-dried, and filled with octafluoropropane gas under negative pressure to obtain powdery microcapsules.
[0053] A pink powdery polymer microca...
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