Multiple responsive high molecular microcapsule and preparation method thereof

A multi-response, polymer technology, applied in the field of biomedical materials, can solve problems such as narrow application range, difficulty in embedding inorganic nanoparticles, and single function of polymer microcapsules

Inactive Publication Date: 2007-10-17
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the function of a single polymer microcapsule is relatively single, and the scope of application is also narrow; at the same time, the microcapsule obtained by this method is difficult to embed multifunctional inorganic nanoparticles, and it is not suitable for encapsulating gas for ultrasound contrast

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] This embodiment 1 is implemented under the following conditions of implementation and technical requirements:

[0032] (1) 0.2g molecular weight is the poly-L-lactic acid of 500,000 and 200mg Fe 3 o 4 Dissolve the magnetic nanoparticles in 20mL of chloroform; prepare 30mL of 0.5% (mass percentage concentration, the same below) polyvinyl alcohol aqueous solution for subsequent use;

[0033] (2) Inject 10 mL of double distilled water into the above mixed solution, and stir at 10000 rpm for 1 min to obtain a water-in-oil emulsion;

[0034](3) Inject the above-mentioned water-in-oil emulsion into the prepared aqueous polyvinyl alcohol solution (the volume ratio of the water-in-oil emulsion to the protective colloid solution is 1:1-1:10, the same below), and stir at 5000rpm for 5min, get a double emulsion;

[0035] (4) Mix 60ml of the above double emulsion with 60mL of water, and stir at 400rpm for 4h;

[0036] (5) The microcapsules were collected by centrifugation, wash...

Embodiment 2

[0039] This embodiment 2 is implemented under the following conditions of implementation and technical requirements:

[0040] (1) 2g molecular weight is 100,000 polycyclolactic acid and 100mg γ-Fe 2 o 3 Dissolve the magnetic nanoparticles in 20mL of dichloromethane; prepare 200mL of 2% polyvinyl alcohol aqueous solution for later use;

[0041] (2) Inject 2 mL of double distilled water into the above mixed solution, and stir at 15000 rpm for 2 min to obtain a water-in-oil emulsion;

[0042] (3) Inject the above water-in-oil emulsion into the prepared aqueous solution of polyvinyl alcohol, and stir at 10000rpm for 4min to obtain a double emulsion;

[0043] (4) Mix 220mL of the above double emulsion with 220mL of water, and stir at 800rpm for 6h;

[0044] (5) The microcapsules were collected by centrifugation, washed twice with distilled water and once with n-hexane, freeze-dried and filled with sulfur hexafluoride gas under negative pressure to obtain powdery microcapsules. ...

Embodiment 3

[0047] This embodiment 3 is implemented under the following conditions of implementation and technical requirements:

[0048] (1) Dissolving 0.5g of polylactide with a molecular weight of 350,000 and 150mg of CdSe nanocrystals in 20mL of chloroform; preparing 60mL of 1% gelatin aqueous solution for subsequent use;

[0049] (2) Inject 8 mL of double distilled water into the above mixed solution, and stir at 15000 rpm for 2 min to obtain a water-in-oil emulsion;

[0050] (3) Inject the above water-in-oil emulsion into the prepared aqueous gelatin solution, and stir at 10000rpm for 5min to obtain a double emulsion;

[0051] (4) Mix 90mL of the above double emulsion with 90mL of water, and stir at 800rpm for 2h;

[0052] (5) The microcapsules were collected by centrifugation, washed once with distilled water and twice with n-hexane, freeze-dried, and filled with octafluoropropane gas under negative pressure to obtain powdery microcapsules.

[0053] A pink powdery polymer microca...

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PUM

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Abstract

The invention relates to a macromolecule microcapsule having multiple response in biomedical material technology art and a method for preparing the same. One or a plurality of small hole(s) are provided within the macromolecule of the invention, saturated with biological inert gas in normal pressure, and separated by macromolecule file. Inorganic nano-particles are connected with macromolecule chain by van der waals force, wrapped and winded by the macromolecule chain and existed in a housing and an inner film of the macromolecule microcapsule. The preparing method of the macromolecule microcapsule having multiple response is also provided in the invention. The preparing method and the macromolecule microcapsule having multiple response in the invention can embed multi-functional inorganic nano-particles and gas for contrast-enhanced ultrasonography. The macromolecule microcapsule of the invention has various functions and abroad application field in art of medicine, biochemistry and the like.

Description

technical field [0001] The invention relates to a polymer microcapsule in the technical field of biomedical materials and a preparation method thereof, in particular to a multi-response polymer microcapsule and a preparation method thereof. Background technique [0002] Encapsulation of substances can achieve many purposes: increase the stability of substances; separate immiscible components; protect substances from the environment; encapsulate aromas, tastes, pesticides, adhesives, active enzymes, living cells, pharmaceuticals, inks and dyes, etc.; convert liquid into solid; control the release of active ingredients; enable drugs to have targeting functions; reduce the adverse impact of toxic substances on the environment, etc. Therefore, microencapsulation technology is attracting more and more attention, and the research field of microencapsulation is increasing day by day, and it is popularized to almost all chemical systems. When the gas or gas precursor is encapsulate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/12A61K49/22
Inventor 孙康窦红静陆蓉
Owner SHANGHAI JIAO TONG UNIV
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