Chinese-medicinal composition for treating malignant tumor and its production

A malignant tumor and composition technology, which is applied in the direction of anti-tumor drugs, drug combinations, and pharmaceutical formulations, and can solve the problems of unreported anti-tumor effects

Inactive Publication Date: 2007-11-21
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to open up the research and development of traditional Chinese medicine for the treatment of malignant tumors, the inventors of the present invention conducted a series of studies on the anti-tumor effect of a new traditional Chinese medicine compound according to the guiding principles of anti-tumor drug pharmacodynamics researc

Method used

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  • Chinese-medicinal composition for treating malignant tumor and its production
  • Chinese-medicinal composition for treating malignant tumor and its production
  • Chinese-medicinal composition for treating malignant tumor and its production

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take the raw materials according to the following weight ratio:

[0014] Curcuma 15g, Banzhilian 30g, Bupleurum 10g, Scutellaria baicalensis 10g, Faxia 15g, Codonopsis 30g, licorice 5g, jujube 10g, ginger 6g.

[0015] Preparation method: add 8 times the amount of water, steam distill and extract the volatile oil twice, and the extraction time is 2 hours each time; combine the medicinal residue and the volatile oil and cook together, add 8 times the amount of water to extract twice, decoct for 2 hours each time, filter After filtering, the filtrate was concentrated into a concentrated solution of 1 g crude drug / ml.

[0016] The traditional Chinese medicine composition of the present invention can be further dried into a clear paste by drying the concentrated solution, and then compressed into tablets or filled with capsules or directly bagged into a powder with the addition of commonly used pharmaceutical adjuvants.

[0017] The traditional Chinese medicine composition ...

experiment example 1

[0018] Experimental example 1 Acute toxicity test of compound traditional Chinese medicine

[0019] Experimental grouping: three groups: drug treatment group (1g crude drug / ml compound Chinese medicine), PBS control group, non-treatment group. There were 10 Kunming mice in each group.

[0020] Experimental steps: (1) Mice were administered orally by gavage. (2) After the pre-test, the compound Chinese medicine with the highest concentration and the largest volume was administered to mice, and none of the mice died, indicating that the acute toxicity of the compound Chinese medicine was low, and LD could not be measured. 50 ; Therefore, this product is only tested for the maximum dosage. (3) Take 30 SPF-grade Kunming mice, weighing 18-22g, divide them into three groups as above, half male and half male, fast for 12 hours before administration, and then give the above-mentioned compound Chinese medicine (1g crude drug / ml) and PBS 0.8ml / Oral administration only, 3 times a day...

experiment example 2

[0022] Experimental example 2 Effect of compound Chinese medicine on the activity of various tumor cells cultured in vitro (SRB method)

[0023] Sulforhodamine B (SRB) is a protein-binding dye that can bind to basic amino acids in biological macromolecules. The OD value at a certain wavelength has a good linear relationship with the number of cells, and can be used as a marker for the number of cells. Quantitative. Digest the logarithmic growth phase tumor cells with trypsin, suspend the cells with RPMI1640 or DMEM containing 10% calf serum, and adjust the cell concentration to 3×10 4 pieces / ml. Inoculate in a 96-well culture plate, 100 μl per well, at 37°C, 5% CO 2 and 100% humidity incubator for cultivation, after culturing for 12 hours, they were divided into drug-dosing group and control group for treatment. Add 200 μl of full culture solution to each well of the control group, and add 200 μl of full culture solution containing various concentrations of drugs to each we...

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Abstract

The invention is concerned with the kind of herbal medicine combination that cures the malignancy in the domainal of antineoplastic medicine, the measurements of the pharmaceutical product that form the combination are: Rhizoma Curcumae 15 shares, Barbed Shullcap Herb 39 shares, Chinese thorowax 10 shares, Baikal skullcap root 10 shares, Pinellia ternata 15 shares, codonopsis pilosula 30 shares, liquorice 5 shares, Chinese date 10 shares, ginger 6 shares; the pharamaceutical product can be regularly decoct, condense or retort to process liquid take orally, tablet, capsule, and powder; the invention shows highly curative effect on tumour and improves the state of the patient from clinic practical, as it is with abundance range of pharamaceutical product resourses that it is usable for assists the liver cancer, nasopharygeal carcinoma and other types of malignancy therapy.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating malignant tumors, and also relates to a preparation method of the traditional Chinese medicine composition. Background technique [0002] Malignant tumors are common and frequently-occurring diseases that seriously threaten human health. The morbidity and mortality are increasing year by year. About 70% to 80% of cancer patients are in the middle and late stages, and most of them lose the chance of early radical surgery. Mainly, although it has a certain short-term curative effect, it often cannot significantly prolong the survival period of patients due to large adverse reactions, short remission period, and poor quality of life. The advantages of traditional Chinese medicine in the treatment of malignant tumors in improving symptoms, improving quality of life, stably shrinking cancer foci, and prolonging surviv...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/08A61K9/10A61K9/14A61K9/20A61K9/48A61P35/00
Inventor 杨惠玲陈泽雄夏洪平
Owner SUN YAT SEN UNIV
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