Simulation system of function of biological organ

A functional simulation and biological technology, applied in the field of simulation systems, can solve problems such as the inability to understand the status of blood sugar-related organs

Inactive Publication Date: 2007-11-28
SYSMEX CORP
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Problems solved by technology

This method can predict the blood sugar level, but cannot understand the status of the organs related to blood sugar control

Method used

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  • Simulation system of function of biological organ
  • Simulation system of function of biological organ
  • Simulation system of function of biological organ

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Experimental program
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Embodiment Construction

[0069] The specific implementation of the biological organ function simulation system will be described in detail below with reference to the accompanying drawings.

[0070] FIG. 1 is a block diagram showing the hardware structure of a biological organ function simulation system according to an embodiment of the present invention. The system 100 of the present embodiment is constituted by a computer 100 a, and is mainly composed of a host computer 110 , a display unit 120 and an input device 130 . Host 110 is mainly composed of CPU110a, ROM110b, RAM110c, hard disk 110d, reading device 110e, I / O interface 110f and image output interface 110h, wherein CPU110a, ROM110b, RAM110c, hard disk 110d, reading device 110e, I / O interface 110f and image output interface 110h The output interface 110h is connected by the bus 110i, and data communication is possible.

[0071] The CPU 110a can execute computer programs stored in the ROM 110b and computer programs loaded by the RAM 110c. Whe...

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Abstract

A simulation system for simulating a function of a biological organ using a biological model in which the function of the biological organ are represented by a mathematical model with a computer is provided. The present system receives input of time-series actual measurement data representing the biological response of a subject, estimates the biological response of the subject at a time point at which the measurement is not performed by using the input time-series actual measurement data, and generates time-series reference data representing the biological response of the subject. The present system further generates a virtual biological organ virtually constructed in a computer system using the times-series reference data. The virtual biological organ corresponds to the function of a biological organ of the subject.

Description

Technical field: [0001] The present invention relates to a computer simulation system for simulating the functions of biological organs, especially the functions of glucose uptake, storage and metabolism, insulin secretion, transport and action in biological organs. Background technique: [0002] The concentration of substances in the living body, especially the concentration of blood sugar and blood insulin, has been recorded using a numerical model for the medical reason that it is representative in the diagnosis of diabetes. The numerical model used here can be, for example, Bergman's minimal model (Bergman's minimalmodel) (such as: Bergman et al., American Journal of Physiology, vol.236 (6), p.E-667-77 (1979), and Bergman et al., Journal of Clinical Investigation, vol. 68(6), p. 1456-67(1981)). [0003] This minimal model takes blood sugar level, plasma insulin concentration, and insulin action amount at the point of action of insulin in peripheral tissues, that is, rem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B10/00G06F17/00G06Q50/00A61B5/00A61B5/145G06Q50/10G09B9/00G16H10/60G16Z99/00
CPCG06F19/3437G16H50/50G16Z99/00
Inventor 高地泰浩齐太计雄清家圣嘉
Owner SYSMEX CORP
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