Single domain antibodies against tnfr1 and methods of use therefor

A tumor necrosis factor and receptor technology, applied in the direction of antibody, anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, anti-animal/human immunoglobulin, etc., can solve problems such as decreased stability
CN101084014AInactive Publication Date: 2007-12-05DORMANTIS LTD
34 Cites 14 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
DORMANTIS LTD
Publication Date
2007-12-05
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides methods for treating inflammatory diseases (e.g., chronic inflammatory diseases) comprising administering an antagonist of Tumor Necrosis Factor Receptor 1. The invention also provides ligands that contain an immunoglobulin single variable domain (domain antibody, dAb) monomer that binds Tumor Necrosis Factor Receptor 1, and methods of using the ligands. Also provided are nucleic acids encoding the ligands, recombinant host cells and methods for preparing the ligands.
Need to check novelty before this filing date? Find Prior Art

Description

[0001] Related application

[0002] This application is a partial continuation application of U.S. Patent Application No. 10 / 985,847 filed on November 10, 2004. It is:

[0003] 1) Part of the continued application of the International Patent Application No. PCT / GB2004 / 004253 (the designated country is the United States) filed on October 8, 2004; and

[0004] 2) Part of the international patent application number PCT / GB2003 / 005646 (the designated country is the United States) filed on December 24, 2003 continues to apply, and the British application number GB 0230202.4 filed on December 27, 2002 is required to be applied in 2003. Priority of the British application number GB 0327706.8 filed on November 28,

[0005] Part of the international patent application number PCT / GB2003 / 002804 (the designated country is the United States) filed on June 30, 2003 continues to apply, and the priority of the British application GB 0230202.4 filed on December 27, 2002 is claimed, which is

[0006] ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More