Method for synthesizing asarin

Abstract

This invention relates to a method for synthesizing alpha-asarone. The eliminating reagents are ethyl acetate and acetic anhydride. The weight / volume ratio of 2,4,5-trimethoxybenzaldehyde to ethyl acetate is 1:(5-50), and that of 2,4,5-trimethoxybenzaldehyde to acetic anhydride is 1:(0.5-5). Organic acids are removed by sodium carbonate aqueous solution. Ethyl acetate is separated by molecular distillation. The alpha-asarone crystal is obtained by recrystallization. The method has such advantages as high product purity, simple process, low production cost, easy industrialization, and good product physicochemical properties. The alpha-asarone product can be directly added into medicines.

Description

technical field

[0001] The invention belongs to a method for synthesizing α-asarone. Background technique

[0002] α-Asarone mainly exists in the volatile oil of natural products such as calamus calamus and other plants. It has sedative, prolonged hypnotic and antibacterial effects. It is mostly used clinically for the treatment of chronic bronchitis, epilepsy, coma and other mental diseases. Since the 1960s, the extraction, synthesis, pharmacology, toxicology and clinical studies of the active ingredient α-asarone monomer of calamus plants have been extensively studied at home and abroad, and significant progress has been made.

[0003] There have been many reports on the synthesis of α-asarone, but the yields of various methods are relatively low, which is not conducive to industrial production. Contents of the invention

[0004] The technical problem to be solved by the present invention is to provide a method for synthesizing α-asarone with higher yield.

[0005] The...