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Control method for preparing salvianolic acid A

A control method, the technology of salvianolic acid, applied in the control field of preparation of salvianolic acid A, can solve the problems of unstable performance, salvianolic acid A being acidic, not universal, etc.

Inactive Publication Date: 2008-02-13
PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After adopting such method steps, the industrialization problem of salvianolic acid A was solved, and the purity of the salvianolic acid A extracted was higher, and the performance was stable, but because the pH value was adjusted with acid in the last step, so, in order to adjust the pH value Adjusted to the required range, the pH value of the acid used is greater than the pH value of the solution to be prepared, therefore, the requirements for the acid are relatively strict and not universal; and the salvianolic acid A in the product is acidic, and its performance is not stable enough

Method used

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  • Control method for preparing salvianolic acid A
  • Control method for preparing salvianolic acid A

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment one kind of control method for preparing salvianolic acid A:

[0026] Take 250 kg of Salvia miltiorrhiza granules, add 8 times the amount of 60% ethanol for ultrasonic extraction 3 times, each time for 20 minutes, and the ultrasonic extraction temperature is 30°C. The extracts were combined, centrifuged with three legs, the centrifugate was concentrated under reduced pressure, the temperature was controlled at 60°C, and concentrated to 1:3, and the concentrated solution was placed in a reaction kettle at 120°C for 6 hours. Take the above-mentioned medicinal solution and pass it through the macroporous resin column, the ratio of the sample amount (calculated based on the dry weight of the original medicinal material) to the macroporous resin is 1:5, first wash with 10 times the column volume of water to remove impurities, and then wash with 10 times the column volume concentration Rinse with 20% ethanol water to remove impurities, then rinse with 40% ethanol w...

Embodiment 2

[0027] Example 2 A control method for preparing salvianolic acid A: basically the same as in Example 1, the difference is that the pH value is adjusted to 4 with potassium hydroxide solution to obtain salvianolic acid A.

Embodiment 3

[0028] Example 3 A control method for preparing salvianolic acid A: basically the same as Example 1, the difference is that the pH value is adjusted to 5 with ammonia water to obtain salvianolic acid A.

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Abstract

The invention discloses a control method for the preparation of salvianolic acid; in the method, the proper quantity of solvent is added into the salvia drinking piece or the smashed salvia to be used as the menstruum; after the extraction and the solid-liquid separation, the extracted liquid reacts at the high temperature and a high pressure; then the medical liquid is added into the chromatography column; after eluted by water, elute with the eluant; collect the high-purity salvianolic acid A solution; compress the eluant until the eluant has no organic solvent under the reduced pressure or the normal pressure; the alkali is used to adjust the pH value of the acquired solution; the solution is extracted with the chloroform or ether organic solvent; after the organic solvent are extracted, the acetic acid ester and similar organics solvents are added into the water for extraction; the medical liquid is compressed and dried with the acetic acid ester and similar organics solvents and then the salvianolic acid A product of 50 to 84 percent is gotten. Through controlling the content of the salvianolic acid A in the final extracted materials, the performance of the final extracted materials are more stable; and the invention is low in the requirements for the chemical medicine, more universal, and more suitable for the industrialization.

Description

technical field [0001] The invention relates to a preparation method of medicinal ingredients, in particular to a control method for preparing salvianolic acid A from salvia miltiorrhiza. Background technique [0002] Salvia miltiorrhiza is one of the most commonly used medicinal materials for promoting blood circulation and is used to treat cardiovascular and cerebrovascular diseases such as angina pectoris, hypertension, coronary heart disease and stroke. In the past two decades, the research on salvianolic acid compounds, the main active components of Danshen, has been active. In vitro and in vivo experiments have shown that salvianolic acid compounds can also treat various diseases, such as tumors, liver diseases, kidney diseases, and peptic ulcers, in addition to treating cardiovascular and cerebrovascular diseases. Most researchers focus on total phenolic acids or salvianolic acid B, while ignoring salvianolic acid A and its derivatives, such as salvianolic acid A sal...

Claims

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Application Information

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IPC IPC(8): C07C67/48C07C69/73A61K36/53A61K125/00
Inventor 王国振朱长福杨会慈
Owner PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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