Use of liquiritigenin in preparing medicament for treating neurodegenerative diseases

A technology of liquiritigen and medicine, which is applied in the field of preparation of medicines for the treatment of neurodegenerative diseases by liquiritigen, and achieves huge social and economic benefits

Inactive Publication Date: 2008-04-02
崔福贵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Experimental results in recent years suggest that levodopa may have a certain neurotoxic effect and accelerate the death of residual dopaminergic neurons

Method used

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  • Use of liquiritigenin in preparing medicament for treating neurodegenerative diseases
  • Use of liquiritigenin in preparing medicament for treating neurodegenerative diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 Preparation of Liquiritigenin

[0018] After dissolving commercially available liquiritin in methanol, acetate buffer containing β-glucosidase (Sigma) was added. Diethyl ether was extracted three times, and the diethyl ether layer was retained. Then use a rotary evaporator to spin dry the ether solution, and scrape off the solid after evaporation to dryness for future use. After dissolving and separating the solid with 10-20% acetonitrile, the separation degree is detected by high performance liquid chromatography (HPLC). The analysis showed that only one product was obtained after 48 hours of reaction, indicating that liquiritin had been completely hydrolyzed, and its purity was calculated as 98.74% by "normalization method". Its molecular weight is 256 through mass spectrometry, and it can be determined that the substance is liquiritigenin.

Embodiment 2

[0019] Example 2 Glycyrrhizin Capsules

[0020] Take 500 grams of glycyrrhizin raw material, 1000 grams of medicinal starch, stir evenly, put into No. 0 capsules, 0.3 grams per capsule, take 2 capsules each time, three times a day.

Embodiment 3

[0021] Example 3 Preparation of Glycyrrhizin Tablets

[0022] Take 500 grams of liquiritigenin raw material and 500 grams of medicinal starch, stir evenly, granulate with appropriate amount of ethanol, granulate, compress into tablets, 0.2 grams per tablet, orally, 2 tablets each time, three times a day.

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Abstract

The technical field of the invention relates to preparation of a drug preparation method with liquiritigenin and combination containing liquiritigenin which is used to treat senile dementia and Parkinson disease. The liquiritigenin is added with excipient and processed into agents such as capsules, tablets, granules and injection, etc. The liquiritigenin has protection and nutrition functions to neurons and has no obvious female activity, thereby being capable of improving memory ability of dementia mouse and adlibitum sports ability of Parkinson disease model mouse.

Description

technical field [0001] The invention relates to the use of liquiritigenin in the preparation of medicines for treating neurodegenerative diseases, in particular to the use of liquiritigenin in the preparation of medicines for treating senile dementia and Parkinson's disease. Background technique [0002] Licorice is the roots and rhizomes of various plants of the genus Glycyrrhiza Linn in the leguminosae family. It was first recorded in "Shen Nong's Materia Medica" and listed as the top grade. Harmonize the effects of various medicines. In recent years, it has been found that licorice not only has a strong detoxification effect, but also has anti-ulcer, anti-inflammation, antispasmodic and cough-relieving effects, lowering blood pressure, lowering blood fat, and anti-cancer effects. The chemical composition of licorice is mainly flavonoids and triterpenoids, and there are a small amount of alkaloids, lignin and coumarin. The molecular formula of the dihydroflavonoid liquir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P25/16A61P25/28
CPCC07D311/32A61P25/16A61P25/28
Inventor 崔福贵
Owner 崔福贵
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