Application of ampelopsis extract in preparing medicament for treating hypertension

A high blood pressure and extract technology, applied in the application of myricetin and myricetin in the preparation of drugs for the treatment of hypertension, in the field of rhodopsin, can solve the problem of no literature on the application of rhodopsin, myricetin and myricetin.

Inactive Publication Date: 2008-04-02
湖北中医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] In the relevant searches of the State Intellectual Property Office, no literature was found on the application of staphylophyllin, myricetin, and myricetin in the preparation of drugs for the treatment of hypertension

Method used

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  • Application of ampelopsis extract in preparing medicament for treating hypertension
  • Application of ampelopsis extract in preparing medicament for treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] According to the technological process shown in Figure 1, three monomeric extracts of staphylophyllin, myricetin and myricetin were obtained from the extraction and separation of the grape.

[0041] Step 1. Weigh 8.5kg of the leaves and tender stems of the grape snake, pulverize them, and extract once with 85kg (10 times the mass of the leaves and stems of the grape leaves and stems) of 95% and 75% ethanol (soak for 24 hours, Flow rate: 10ml / min), combine the extracts, recover ethanol under reduced pressure and concentrate to a small volume (5.5L), add water to disperse (add water to 12L), extract with petroleum ether and ethyl acetate in sequence, and decompress the extraction part of ethyl acetate Recover solvent, and dry under reduced pressure to obtain extract 1360g;

[0042] Step 2, take 200g of the extract obtained in step 1 and mix well with silica gel according to the mass ratio of 1:1, add it to the upper end of a 2000g silica gel column, carry out column chrom...

Embodiment 2

[0065] Effects of the extracts of snake grapes, ostaphyllin, myricetin and myricetin, on experimental hypertension.

[0066] Step 1. First add 10mL of edible peanut oil into the mortar, then add 10mL of Span-80 and stir evenly, then slowly add 80mL of distilled water, and keep stirring in the same direction until a milky white emulsion is obtained, and the blank control reagent is obtained.

[0067] Step 2. Put 1.234g of Compound Apocynum Tablets I into a mortar, add 10mL of edible peanut oil, then add 10mL of Span-80 and stir evenly, then slowly add 80mL of distilled water, and keep stirring in the same direction until a milky white emulsion is formed. That is, the positive control test drug was obtained.

[0068]Step 3. Take appropriate amount of Ophiophyllin, Myricetin, and Myricetin from the Snake Grape Extract respectively, put them in a mortar, add 10mL of edible peanut oil, then add 10mL of Span-80 and stir evenly, then slowly add 80mL of distilled water, along the Sti...

Embodiment 3

[0087] Tablet: 1 part by weight of staphylophyllin or myricetin or myricetin or any combination of the three, 0.5-2 parts by weight of lactose, 0.5-2 parts by weight of dextrin, 0.03-0.15 parts by weight of sodium carboxymethylcellulose, the above The ingredients are mixed in a mixer and compressed into tablets.

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PUM

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Abstract

The invention discloses the application of the extract of ampelops megalophylla for preparing the medicine for treating hypertention. The invention discloses the technology of extracting drug materials of ampelopsin, myricetin and myricetrin from the ampelops megalophylla to prepare the medicine for treating hypertention as well as the curative effect on hypertention of a combination medicine combined by the three monomer composition or any combination among the three and pharmacology-allowed additional components and has a good prospect.

Description

technical field [0001] The present invention relates to the extraction method and application of Ampelopsin, Myricetin and Myricetrin from the extracts of Snake Grape in the application. Background technique [0002] Ampelopsi.megalophylla Diels et.Gilg, also known as Ampelopsi.megalophylla Diels et.Gilg, is a plant of the genus Ampelopsi in the family Vitaceae. It is a folk medicine in Enshi, Hubei Province. Its medicinal parts are tender stems and leaves. The drug is recorded in "Hubei Chinese Herbal Medicine", and has the effect of lowering blood pressure and cholesterol; it is clinically used to treat essential hypertension, and the curative effect is remarkable. The folks in Enshi area pick young branches and leaves in summer, put them in boiling water for a while, pick them up immediately, drain the water, spread them in a ventilated place to dry them, and dry them for collection when there are white frost on the surface, which is called mildew. Tea, boiled water to ...

Claims

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Application Information

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IPC IPC(8): A61K36/87A61K9/00A61K9/16A61K9/20A61K9/48A61P9/12C07D311/30A61K127/00A61K135/00
Inventor 张秀桥刘焱文沈伟陈树和舒凌纬陈夏净
Owner 湖北中医学院
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