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Method for extracting proanthocyanidins

An extraction method and technology of proanthocyanidins, which are applied in the direction of pharmaceutical formulas, plant raw materials, medical preparations containing active ingredients, etc., can solve problems affecting extraction efficiency, yield, and low proanthocyanidin content

Inactive Publication Date: 2008-04-02
徐奎根 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing proanthocyanidin extraction still uses pine bark and grape seeds as the main raw materials. The content of proanthocyanidin in these plants is not very high, which naturally affects the extraction efficiency and yield

Method used

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  • Method for extracting proanthocyanidins

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Preparation of desugared mulberry freeze-dried powder

[0016] After picking, it is washed by bubbling with clean water, then sprayed, air-dried at room temperature, and then put into a beater to make a pulp, and continue to stir for 5 minutes. Detect the obtained fruit pulp, its water content is 90%, and the sugar content is 7%. Put the pulp into a quick-freezing tray, control the thickness of the pulp to 4 cm, and freeze it to -20°C to make it completely solidified. Take out the quick-frozen plate, thaw at room temperature (30°C), filter off the leached water, and check that the moisture content of the remaining pulp is 80%, which is in line with S0 / (6S 0 +19T 0 ) formula requirements, dehydration and desugaring are completed. It is air-dried at a low temperature of -20°C until the moisture content is 5%, and crushed with an airflow, so that the particle size is less than 10 microns, and the processing is completed.

Embodiment 2

[0018] Extraction of proanthocyanidins

[0019] Take 1 Kg of the desugared mulberry freeze-dried powder of Example 1, add 30 Kg of 40% ethanol, and at 40° C., sonicate for 10 minutes at a power of 120 W, and freeze-dry to obtain 90 g of 95% proanthocyanidins.

Embodiment 3

[0021] Extraction of proanthocyanidins

[0022] Take 1Kg of the desugared mulberry freeze-dried powder of Example 1, add 10 times the amount of PH=8 aqueous solution, extract at 80°C for 90 minutes, and repeat the extraction twice; the filtrate is transferred to a neutral upper macroporous adsorption resin column, washed with water and collected The 50% ethanol eluate was vacuum-dried under reduced pressure to obtain 95 g of 95% proanthocyanidins.

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Abstract

The present invention discloses an extraction method of original anthocyanins. In the method, the mulberry fruit is used as raw material; the mulberry after being cleaned is crushed into fruit puree; the fruit puree is stirred evenly. After dehydration and doffing of sugar, the fruit puree is dried at a temperature of minus 20 DEG C until the content of water is lower than 5 percent; the dried fruit puree is crushed in a super-micro way. Then the known extraction method is used for extracting. The present invention has a high production rate; no solvent residue or environmental pollution can be produced; the comprehensive value of utilization is also high.

Description

technical field [0001] The invention belongs to the field of biochemical technology, in particular to a method for extracting proanthocyanidins. Background technique [0002] Proanthocyanidins are natural polyphenol compounds belonging to bisflavone derivatives that widely exist in the plant kingdom. These compounds are polymerized by different numbers of catechins or epicatechins. The most widely studied ones are present in grape seeds. From 5,7,3',4'-tetrahydroxyflavan-3 alcohol (5,7,3',4'-tetrahydroxyflavan-3-ol), namely (+)-catechin ((+)-catechin ), (-)-epicatechin ((-)-epicatechin) as the unit polymerization of such compounds, also known as leucocyanidins or procyanidins. The simplest proanthocyanidins are dimers formed by catechin or epicatechin or catechin and epicatechin. In addition, there are trimers, tetramers, etc. to 15-mers, usually two to tetramers The body is called oligomers (Procyanidolic Oligomers, referred to as OPC), and the ones above pentamers are ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/04A61K36/605A61K131/00
Inventor 徐奎根江月仙
Owner 徐奎根
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