Method for improving volume of production of rifamycin

A high-yield, high-quality technology, applied in the field of increasing the yield of rifamycin, can solve problems such as low success rate, unstable high-yielding strains, and prone to reverse mutations
CN101153274AInactive Publication Date: 2008-04-02SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
Publication Date
2008-04-02
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The present invention relates to a method of controlling the two-component regulatory system of bacteria, in particular to an amrE gene and / or an amkE gene or homologous genes of the amrE gene or the amkE gene, which improves the yield of antibiotics and other useful secondary metabolites.
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Description

technical field

[0001] The present invention relates to a method for increasing the production of antibiotics and other useful secondary metabolites by controlling the two-component regulatory system of bacteria, especially the amrE and / or amkE genes or their highly homologous genes. In particular, the present invention relates to Amycolatopsis mediterranei and a method for producing rifamycin using the bacteria. Background technique

[0002] The two-component regulatory system (two-component systems) is an important signal transduction regulatory system in bacterial cells, which is composed of sensor protein (sensor kinase) and response regulator protein (response regulator) (Parkinson JS and Kofoid EC.Communication modules in bacterial signaling proteins. Annu Rev Genet. 1992;26:71-112). Bacteria first feel the stimulation of external signals. In the presence of ATP, the histidine site of the sensing protein undergoes autophosphorylation, and then transfers the high-energ...

Claims

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