Pharmaceutical preparation containing arginine glutamic acid

A technology of arginine glutamic acid and pharmaceutical preparations, which is applied in the field of preparation of arginine glutamic acid pharmaceutical preparations, and can solve problems such as unfavorable emergency treatment, vascular stimulation, and electrolyte imbalance in patients

Inactive Publication Date: 2008-04-09
BEIJING JIASHILIANBO PHARM SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the characteristics of the product itself, the three drugs generally need to be used in combination to achieve a better effect of reducing blood ammonia. There are many limitations in its clinical application, and blood gas analysis and potassium and sodium content must be measured during the medication.
Such cumbersome medication operations are very unfavorable for emergency treatment; and because a large amount of potassium ions, sodium ions and chloride ions are brought into the medication, it is very easy to cause electrolyte imbalance in the patient's body, and potassium ions have a significant stimulating effect on blood vessels. Patients are often in excruciating pain

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Add 17.4g of arginine and 14.7g of glutamic acid to 32.1g of lactose, dissolve in 300ml of water for injection, stir evenly, adjust the pH of the solution to 7.0 with sodium citrate, add 0.1% (W / V) 732 type Activated carbon is used for the injection, stirred at room temperature for 10-60 minutes, filtered, and the filtrate is sterilized by filtration through a microporous membrane, subpackaged, frozen, vacuum-dried, plugged, and capped to obtain a finished freeze-dried powder injection.

Embodiment 2

[0055] Dissolve 8.7g of arginine and 14.7g of glutamic acid in 120ml of water for injection, stir well to prepare solution A; dissolve 46.8g of lactose in 100ml of water for injection, stir to dissolve, and prepare solution B; Mix the two solutions of A and B, adjust the pH value of the solution to 7.0 with sodium carbonate, add 0.1% (W / V) 732 activated carbon for injection, stir and decolorize at room temperature for 10-60min, filter, and filter the filtrate through a microporous membrane. Bacteria, subpackaging, freezing, vacuum drying, plugging, and capping to obtain the finished freeze-dried powder preparation.

Embodiment 3

[0057] Add 17.4g of arginine and 7.3g of glutamic acid to 90ml of water for injection, stir to dissolve, and prepare solution A, add 49.0g of mannitol to 150ml of water for injection, stir and mix evenly, and adjust the pH value of the solution with citric acid If it is 7.0, add 0.2% (W / V) 732 type activated carbon for injection, stir at room temperature for 10-60min to decolorize, filter, and filter the filtrate through a microporous membrane to sterilize, sub-package, freeze, vacuum dry, press stopper, press Cover to obtain the finished freeze-dried powder preparation.

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PUM

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Abstract

The invention relates to the medicament preparation of arginine glutamic acid and the preparation method and the application thereof. Through long-term experimental study, the personnel of the invention develops the medicament preparation of the arginine glutamic acid, the preparation takes the arginine glutamic acid as raw material medicine, which prepares the preparation with proper medicinal auxiliary material. The operating process of the medicament preparation of the invention is simple, the environmental pollution is small, and the invention is suitable for the production of a great industry. A pharmacological test shows that the medicament preparation of arginine glutamic acid has a very obvious pharmacological function on the aspect of the remedy of the hyperammonemia caused by acute liver disease and chronic liver disease such as hepatocirrhosis, fatty liver and hepatitis.

Description

technical field [0001] The invention belongs to the field of medicine and pharmacy, and in particular relates to a preparation method and application of an arginine glutamic acid pharmaceutical preparation. Background technique [0002] The liver is the largest organ in the human body and has the functions of synthesizing, storing, metabolizing, and detoxifying various nutrients. Severe damage to human liver function can lead to disorders of ammonia metabolism in the body, resulting in a state of high blood ammonia in the body, causing damage to important organs of the human body, such as liver damage and hepatic encephalopathy. Liver injury includes chemical liver injury, mechanical liver injury and hepatitis. The clinical treatment of hepatic encephalopathy caused by liver injury generally adopts a comprehensive treatment plan such as adjusting diet, adjusting amino acid profile, and maintaining acid-base electrolyte balance. At present, there are very few blood ammonia-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61K9/14A61K9/16A61K9/19A61P1/16A61P3/02A61P7/00
Inventor 陈小平阎亚矢刘桦
Owner BEIJING JIASHILIANBO PHARM SCI & TECH
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