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Prostaglandin F2a derivative inclusion product

A technology of prostaglandins and derivatives, applied in the direction of medical preparations containing active ingredients, medical preparations with non-active ingredients, packaging items, etc.

Inactive Publication Date: 2008-05-07
SANTEN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, regarding the material of resin containers, there is no report on the stabilization of prostaglandin derivatives by changing the ratio of each monomer component of the propylene-ethylene copolymer.

Method used

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  • Prostaglandin F2a derivative inclusion product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0030] [Storage Stability Test]

[0031] (1) Preparation of eye drops

[0032] As a representative example of prostaglandin F2α derivatives having a fluorine atom in the molecule, 16-phenoxy-15-deoxy-15,15-difluoro-17,18,19,20-tetranorprostaglandin F2α isopropyl base ester (hereinafter referred to as "the compound"). After dissolving the compound (0.0005%) and polysorbate 80 (0.05%) in purified water, mix with disodium edetate (appropriate amount), concentrated glycerin (appropriate amount) and benzalkonium chloride (appropriate amount) etc. Additives, etc., to obtain eye drops with an osmotic pressure of about 1 and a pH of about 6.

[0033] (2) Preparation of resin container

[0034] The resin container of the present invention is a propylene-ethylene random copolymer (propylene component / ethylene component=98.7 / 1.3, propylene component / ethylene component=97.4 / 2.6, propylene component / ethylene component=96.4 / 3.6) and propylene homopolymer The objects are respectively obt...

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Abstract

The present invention provides a resin-made container which enables long-term stable preservation of aqueous liquid preparations containing prostaglandin F2a derivatives having fluorine atoms in the molecule. An aqueous liquid preparation containing a prostaglandin F2a derivative having a fluorine atom in the molecule is protected from lowering in the prostaglandin F2a derivative content by keeping the preparation in a container made of a propylene / ethylene copolymer having a propylene / ethylene ratio of 94.0 / 6.0 to 99.5 / 0.5.

Description

technical field [0001] The present invention relates to a product containing a prostaglandin F2α derivative, which is obtained by preserving an aqueous liquid preparation containing a prostaglandin F2α derivative having a fluorine atom in its molecule in a mixture of propylene and ethylene. In a resin container made of a propylene-ethylene copolymer having a ratio of propylene component / ethylene component=94.0 / 6.0 to 99.5 / 0.5, a decrease in the content rate of the prostaglandin F2α derivative in the aqueous liquid preparation can be suppressed. Background technique [0002] Prostaglandin F2α derivatives having fluorine atoms in their molecules are known to be useful as therapeutic agents for glaucoma and ocular hypertension (Patent Document 1, Patent Document 2). However, since the prostaglandin F2α derivatives having fluorine atoms in the molecule are generally poorly soluble in water and have the property of being easily adsorbed on containers, it is necessary to improve t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5575A61P27/02A61K9/08A61J1/05A61K47/34
CPCC08L23/142C08L2203/02A61K9/0048A61K31/5575A61K47/26A61K47/186A61K47/10A61K47/18C08L23/10C08L53/00Y10T428/1352A61P27/02C08L2666/06C08L2666/02A61K47/34A61K9/08
Inventor 木村章男山田博门武博
Owner SANTEN PHARMA CO LTD
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