Method for preparing chitosan-polyasparagic acid-5efudix nano particle

Abstract

The invention relates to a preparation method of chitosan aspartate 5-fluorouracil-loaded nanoparticle. The invention makes use of the process to form the ionic compound of chitosan and aspartate to carry out the loading of 5-fluorouracil, so as to prepare the chitosan aspartate 5-fluorouracil-loaded nanoparticle water dispersion system by changing the molecular weight, molar ratio, reaction conditions and other factors of the raw materials under the mild reaction conditions, and the nanoparticle powder is obtained by freeze drying. The chitosan aspartate 5-fluorouracil-loaded water dispersion system of the invention is the nanoparticle with even dispersion and spherical shape. The product of the invention can be re-dispersed into the nanoparticle in water and has certain target and sustained-release performances. The invention has simple method and easy obtainment of raw materials; compared with the oral formulations on the market, the intestinal absorption efficiency and the bioavailability of the invention are significantly improved after oral administration, so the invention has better efficacy on malignant tumors.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and in particular relates to a method for preparing chitosan-polyaspartic acid-5-fluorouracil nanoparticles by ion crosslinking reaction. Background technique [0002] Nanoparticles have many advantages in drug delivery, such as slow release of drugs, thereby prolonging the action time of drugs; achieving the purpose of targeted delivery of drugs; Or avoid adverse reactions; it can improve the stability of the drug, which is beneficial to storage; it is also possible to establish some new routes of administration, including local administration in vivo, mucosal absorption administration, and oral administration of polypeptides. At present, the carriers that can be used to prepare drug nanoparticles mainly include synthetic, biodegradable, high molecular polymers and natural macromolecular systems. Synthetic biodegradable polymers include: polyanhydrides, polycaprolactones, polylactic...

AI Technical Summary

Problems solved by technology

At present, there are many disadvantages in the clinical use of 5-FU, such as oral administration is not easy to absorb, metabolism in the body is fast, half-life is short (only 5-10min), toxic and side effects are large, and large doses of long-term intravenous infusion are required to achieve effective effects in the body. Concentration and duration of action. In addition, the absorption of 5-FU is irregular. If the concentration in the body is too high, toxic and side effects will occur, which will bring great inconvenience and pain to patients.