Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cortex moutan valid target pharmaceutical combination, preparation method and application thereof

A technology of effective parts and compositions, applied in the pharmaceutical composition of effective parts of paeonol, its preparation and application, to achieve the effects of fixed main component content and ratio, low cost, stable and controllable quality

Inactive Publication Date: 2008-05-21
戴敏
View PDF2 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Chinese patents CN1418673A and CN1788753A respectively provide a method for preparing total paeony glycosides, but the total paeony glycosides prepared by the method are mainly water-soluble glycosides, excluding paeonol, the main active ingredient of paeony

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cortex moutan valid target pharmaceutical combination, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The preparation of embodiment 1 paeonol effective fraction composition

[0047] Take paeonol medicinal material 5kg, cut into decoction pieces, put it in a still, add 20L of water to distill, collect 8L of distillate, refrigerate (0-10°C), overnight, filter to obtain 29g of paeonol crystals. Filter the paeonol water infusion in the distiller, and place the filtrate for later use. Take the above filter residue, add 50L water to extract 3 times, each time for 1 hour; combine the extracts, combine the above filtrates, apply macroporous adsorption resin column chromatography, first elute with water, then elute with 90% ethanol, collect 90% ethanol The eluate was concentrated under reduced pressure and dried to obtain 221 g of total paeonol glycosides. Paeonol was mixed with total paeonol glycosides to prepare 250 g of paeonol effective fraction composition, with a yield of 5.0%. It is determined that the total paeonol and total paeonol glycosides contained in the paeonol ...

Embodiment 2

[0049] The preparation of embodiment 2 paeonol effective fraction composition

[0050] Take paeonol medicinal material 5kg, cut into decoction pieces, put into a distiller, add 40L of water to distill, collect 25L of distillate, refrigerate (0-10°C), overnight, filter to obtain 67g of paeonol crystals. Filter the paeonol water infusion in the distiller, and place the filtrate for later use. Take the above filter residue, add 100L 50% ethanol to extract once, and extract for 3 hours; combine the extracts, recover ethanol under reduced pressure, combine with the above filtrate, and perform chromatography on a macroporous adsorption resin column, first elute with water, and then use 80% ethanol For elution, the 80% ethanol eluate was collected, concentrated under reduced pressure, and dried to obtain 260.5 g of total paeonol glycosides. Paeonol was mixed with total paeonol glycosides to obtain 327.5 g of paeonol effective part composition, with a yield of 6.55%. It is determine...

Embodiment 3

[0052] The preparation of embodiment 3 paeonol effective fraction compositions

[0053] Take 5 kg of paeonol medicinal material, crush it into coarse powder, put it in a distiller, add 100 L of water to distill, collect 75 L of distillate, refrigerate (0-10° C.), overnight, and filter to obtain 88 g of paeonol crystals. Filter the paeonol water infusion in the distiller, and place the filtrate for later use. Take the above filter residue, add 40L of water, extract twice, each time for 1 hour; combine the extracts, and combine with the above filtrate, apply macroporous adsorption resin column chromatography, first elute with water, then elute with 70% ethanol, collect The 70% ethanol eluate was concentrated under reduced pressure and dried to obtain 288 g of total paeonol glycosides. Paeonol was mixed with total paeonol glycosides to prepare 376 g of paeonol effective part composition, with a yield of 7.54%. It is determined that the total paeonol and total paeonol glycosides...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The medicinal composition of effective parts of paeonol, its preparation method and application, is characterized in that the medicinal composition contains 10-40% of paeonol and 10-50% of paeonol total glycosides in terms of weight percentage; wherein, paeonol The total amount of phenol and total paeonol glycosides is not less than 50%. The preparation method is to soak paeonol medicinal material powder or decoction pieces in water, heat and distill, and place the distillate under cooling to precipitate and crystallize paeonol; Solution extraction, the extract and the filtrate are put on a macroporous adsorption resin column, firstly eluted with water, then with alcohol, and the alcohol eluate is collected; the alcohol is recovered under reduced pressure, concentrated and dried to obtain paeonol total glycosides; paeonol and The total glycosides of paeonol are mixed to prepare the composition of effective parts of paeonol. The effective part composition of paeonol cortex of the invention can be used to prepare medicines for preventing and treating fat metabolism diseases and cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a composition of effective parts of paeonol cortex and its preparation method, as well as its application in the preparation of medicines for treating or preventing fat metabolism diseases and cardiovascular and cerebrovascular diseases. Background technique [0002] The disorder of lipid metabolism in the body can lead to various cardiovascular and cerebrovascular diseases such as fatty liver, hyperlipidemia, and atherosclerosis. Fatty liver is not an independent clinical disease, but a pathological state caused by various diseases and causes of intrahepatic lipids, mainly triglyceride accumulation, and is also a common pathology in the development of various liver diseases process, with an incidence of about 10% of the average population. Although generally considered to be a benign and static lesion, if the pathogenic factor continues to act, it can develop into irreversible liver damage in a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P1/16A61P3/06A61P9/10A61K129/00
Inventor 戴敏桂双英
Owner 戴敏
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com