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Method for preparing folic acid

A technology of folic acid and sulfate, applied in the direction of organic chemistry, can solve the problems of high production cost, low yield, complicated process, etc., and achieve the effect of improving product quality, increasing product yield, and enhancing product quality

Inactive Publication Date: 2010-06-16
潘福星
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This synthetic method has complex process, harsh conditions, long reaction cycle, low yield, high cost, and difficult to obtain raw materials.
There is also the reaction of 2-substituted malondialdehyde with p-aminobenzoyl-L-glutamic acid to obtain the corresponding diimine, and then react with triaminopyrimidone at a pH value of 3-8 in the presence of sulfite Prepare folic acid, although the yield of this method is improved, but the production cost is very high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) First prepare the intermediate product N-p-aminobenzoylglutamic acid:

[0038] a. Weigh the raw materials:

[0039] P-Nitrobenzoyl chloride: 100Kg

[0040] Sodium glutamate: 100Kg

[0041] b. The condensation reaction and the reduction reaction are carried out in sequence:

[0042] Condense the p-nitrobenzoyl chloride and sodium glutamate that meet the above-mentioned ratio requirements at a temperature of 5-15°C and a pH of 7-9 for 1 to 2.5 hours; then add hydrochloric acid to adjust the pH to 4.0 ~6.5, and then use hydrogen in the nickel-aluminum alloy catalyst at a temperature of 30-70℃ to carry out the reduction reaction. The amount of the nickel-aluminum alloy catalyst is 1 / 15 of the weight of the reduced substance; after the reaction is completed, the pH is adjusted to 1.0~3.0 with hydrochloric acid , Get the intermediate product N-p-aminobenzoyl glutamic acid;

[0043] (2) Prepare the intermediate product 6-hydroxy-2,4,5-triaminopyrimidine sulfate:

[0044] a. Weigh th...

Embodiment 2

[0060] (1) First prepare the intermediate product N-p-aminobenzoylglutamic acid:

[0061] a. Weigh the raw materials:

[0062] P-Nitrobenzoyl chloride: 100Kg

[0063] Sodium glutamate: 110Kg

[0064] b. The condensation reaction and the reduction reaction are carried out in sequence:

[0065] Condense the p-nitrobenzoyl chloride and sodium glutamate that meet the above requirements for 2.5-3.5 hours at a temperature of 10-15°C and a pH of 9-10; then add hydrochloric acid to adjust the pH to 6.5 ~7.0, then use hydrogen in the nickel-aluminum alloy catalyst at a temperature of 70-90℃ to carry out the reduction reaction, the amount of the nickel-aluminum alloy catalyst is 1 / 10 of the weight of the reduced substance; after the reaction is completed, adjust the pH to 3.0~3.5 with hydrochloric acid , Get the intermediate product N-p-aminobenzoyl glutamic acid;

[0066] (2) Prepare the intermediate product 6-hydroxy-2,4,5-triaminopyrimidine sulfate:

[0067] a. Weigh the raw materials:

[0068]...

Embodiment 3

[0083] (1) First prepare the intermediate product N-p-aminobenzoylglutamic acid:

[0084] a. Weigh the raw materials:

[0085] P-Nitrobenzoyl chloride: 100Kg

[0086] Sodium glutamate: 200Kg

[0087] b. The condensation reaction and the reduction reaction are carried out in sequence:

[0088] Condense the p-nitrobenzoyl chloride and sodium glutamate that meet the above-mentioned ratio requirements for 3 to 5 hours at a temperature of 15-30°C and a pH of 9 to 11; then add hydrochloric acid to adjust the pH to 6.0 ~7.0, then use hydrogen under the action of palladium-carbon catalyst at a temperature of 80-100℃ to carry out the reduction reaction, the amount of palladium-carbon catalyst is 1 / 15 of the weight of the reduced material; after the reaction is completed, adjust the pH to 4.0~5.0 with hydrochloric acid, The intermediate product N-p-aminobenzoyl glutamic acid;

[0089] (2) Prepare the intermediate product 6-hydroxy-2,4,5-triaminopyrimidine sulfate:

[0090] a. Weigh the raw materi...

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Abstract

The present invention relates to a preparation method of folic acid, the technical steps of which are as follows: firstly, p-nitrobenzoyl chloride and sodium glutamate are used to prepare for a mediumproduct N-p-amino-benzoyl glutamic acid; then, methyl cyanoacetate, guanidine nitrate and sodium methoxide are used to prepare for the medium product 6-hydroxyl-2, 4, 5-triamino pyrimidine sulfate; finally, the two kinds of medium products are used to prepare for a crude product of the folic acid which is refined to obtain the pure product of the folic acid. The present invention has the beneficial effects of reducing the production cost greatly, improving the product efficiency and reducing the pollution to the environment.

Description

Technical field [0001] The invention relates to a preparation method of folic acid. Background technique [0002] Folic acid is a basic variety of vitamins and is an anti-anemia drug used in feed, medicine, food and other fields. In the food industry, it is used as a nutritional supplement, in the feed industry as an anti-anemia drug additive; in the pharmaceutical industry, folic acid is often used to treat cell anemia, colorectal cancer and other diseases. [0003] The traditional synthetic method of folic acid uses para-amino, α, β-dibromopropionaldehyde, and triamino to react in acetic acid-sodium acetate buffer solution to obtain crude folic acid. After purification, folic acid containing 2 molecules of crystal water is obtained. This synthetic method has the disadvantages of complicated process, demanding conditions, long reaction period, low yield, high cost, and unavailability of raw materials. There is also the reaction of 2-substituted malondialdehyde with p-aminobenzoy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D475/04
Inventor 潘福星马凤霞张磊于国宁安文德刘向军黄铁彪
Owner 潘福星
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