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Medicinal composition for treating diabetes chronic complication and preparation method thereof

A composition and diabetes technology, applied in the field of medicine, can solve problems such as literature and patent reports on compound preparations that have not been seen

Inactive Publication Date: 2008-05-28
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Through the search, there are no relevant literature and patent reports on the compound preparations of the above-mentioned various drugs

Method used

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  • Medicinal composition for treating diabetes chronic complication and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 lipoic acid and methylcobalamin tablet

[0024] prescription:

[0025] components

Dosage

lipoic acid

Mecobalamin

microcrystalline cellulose

CMS-Na

Micropowder silica gel

Co-made

100g

0.5g

90g

5g

4.5g

1000 pieces

[0026] Preparation:

[0027] Pass lipoic acid and microcrystalline cellulose through a 80-mesh sieve, mix well, and set aside; take another appropriate amount of 50% ethanol solution, add methylcobalamin to dissolve, use this solution as a binder to make a soft material, and granulate with a 24-mesh sieve , dried at 50°C, granulated with a 20-mesh sieve, added with micropowdered silica gel and CMS-Na, mixed evenly, and pressed into tablets with a suitable die to obtain the product.

[0028] If the above-mentioned tablet is coated, a coated tablet can be obtained, which can be a film-coated tablet, an enteric-coated tablet, and the like....

Embodiment 2

[0030] Embodiment 2: compound methylcobalamin+lipoic acid+calcium dobesilate capsules

[0031] prescription:

[0032] components

Dosage

lipoic acid

Mecobalamin

calcium dobesilate

starch

Magnesium stearate

Co-made

100g

0.5g

500g

10g

10g

1000 capsules

[0033] Preparation:

[0034] Pass lipoic acid and calcium dobesilate through an 80-mesh sieve, mix them evenly with starch, and set aside; take an appropriate amount of 50% ethanol solution, add methylcobalamin to dissolve, and use this solution as an adhesive to make a soft material. Granulate with a mesh sieve, dry at 50°C, granulate with a 20-mesh sieve, add magnesium stearate, mix evenly, pack separately, and obtain.

[0035] The used capsule shell can be a common capsule or an enteric-coated capsule.

[0036] The above steps should be strictly protected from light.

Embodiment 3

[0037] Example 3: Compound lipoic acid + epalrestat + calcium dobesilate and methylcobalamin chewable tablet

[0038] prescription:

[0039] components

Dosage

lipoic acid

Epalrestat

calcium dobesilate

Sorbitol

Sweet Orange Powder Flavor

Micropowder silica gel

Co-made

100g

50g

500g

500g

30g

20g

1000 pieces

[0040] Preparation:

[0041] Pass lipoic acid, epalrestat, and calcium dobesilate through an 80-mesh sieve, mix them evenly with sorbitol, take an appropriate amount of 50% ethanol solution, use it as a soft material for binder, granulate with a 24-mesh sieve, and heat at 50°C Dry and sieve through a 20-mesh sieve. Add sweet orange powder essence and micro-powder silica gel, mix evenly, and press into tablets to obtain the product.

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PUM

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Abstract

The invention relates to a series of medical compositions used for treating chronic complications of diabetes and preparation methods thereof; the invention are oral compound preparations (including tablet, dispersible tablet, effervescent tablet, capsule, soft capsule and granule) prepared by at least two active components of mecobalamine, cobamamide, vitamine B12, epalrestat, lipoic acid and calcium dobesilate and the pharmaceutically accepted excipients. The preferential compositions of the invention are mecobalamine+ lipoic acid, mecobalamine+ lipoic acid+ calcium dobesilate, mecobalamine+epalrestat+ calcium dobesilate, mecobalamine+ lipoic acid+ epalrestat+ calcium dobesilate, and mecobalamine+ vitamine B12+ cobamamide. The invention is mainly used for treating neuropathy in chronic complications of diabetes.

Description

technical field [0001] The invention relates to a series of pharmaceutical compositions for treating chronic complications of diabetes and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Diabetic peripheral neuropathy (DPN) is related to many factors, such as sugar alcohol metabolism disorder, Na+-K+-ATPase activity reduction, blood circulation disorder leading to blood hypercoagulability, abnormal blood cells, hardening of blood vessels, etc. The blood of DPN patients has thick, viscous, coagulation, aggregation and abnormal blood rheology and abnormal shape, vascular endothelial cells are damaged, blood vessels, especially microvascular walls are thickened, permeability is increased and microthrombosis is formed, resulting in nerve tissue ischemia and hypoxia. It causes enhanced oxidative stress and increased generation of free radicals, causing a series of oxidative reactions, leading to nerve damage. The unified ...

Claims

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Application Information

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IPC IPC(8): A61K31/714A61K9/16A61K9/20A61K9/46A61K9/48A61P3/10A61P25/00A61K31/185A61K31/381A61K31/426
Inventor 陈瑞晶
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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