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Kudzu root total flavone extracting after steam-explosion process

A technology of Pueraria total flavonoids and total flavonoids, which is applied in chemical instruments and methods, pharmaceutical formulas, non-central analgesics, etc., to achieve the effect of improving the extraction rate

Inactive Publication Date: 2010-12-08
INST OF PROCESS ENG CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The components of kudzu root are complex, but the treatment before extraction is generally only simple crushing of medicinal materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: get 50g of kudzu root, cut into small sections, drop into steam explosion tank, process 4.0 minutes under steam pressure 0.5 Mpa; Add water as 1: 4 by the mass ratio of steam explosion kudzu root and water, adjust pH value to be 10 , filtered after leaching at normal temperature for 60min; the filtrate is concentrated to a soluble solid content greater than or equal to 10% under the condition of vacuum degree-0.08Mpa and temperature of 60°C, and then the volume ratio of the concentrated solution and 95% ethanol is 1: 2.1 Add 95% ethanol or add absolute ethanol according to the volume ratio of the concentrated solution and absolute ethanol as 1:1.8, and centrifuge after standing for 2 hours; 60% ethanol, reflux extraction at 80°C for 3 times, each time for 1h; combine the extracts, recover the ethanol at 50°C with a vacuum degree of -0.08Mpa, and obtain the total flavonoids extract of Pueraria radiata, and dry it to obtain the total flavonoids of Pueraria ra...

Embodiment 2

[0016] Embodiment 2: get 50g of kudzu root, cut into small sections, drop into the steam explosion tank, process 3.0 minutes under the steam pressure of 0.7Mpa; be 1: 6 to add water by the mass ratio of steam explosion kudzu root and water, adjust the pH value to be 6 , filtered after leaching at normal temperature for 40min; the filtrate is concentrated to soluble solids greater than or equal to 10% under the condition of vacuum degree-0.08Mpa and temperature of 60°C, and then the volume ratio of the concentrated solution and 95% ethanol is 1: 2.8 Add 95% ethanol or add absolute ethanol according to the volume ratio of the concentrated solution and absolute ethanol as 1:2.3, and centrifuge after standing for 2 hours; 75% ethanol, reflux extraction at 70°C for 2 times, each time for 1.5h; combine the extracts, recover the ethanol at 50°C with a vacuum degree of -0.08Mpa, and obtain the total flavonoids extract of Pueraria radiata, and obtain the total flavonoids of Pueraria rad...

Embodiment 3

[0017] Embodiment 3: get 50g of kudzu root, cut into small sections, drop into the steam explosion tank, process 2.5 minutes under steam pressure 0.8Mpa; be 1: 8 to add water by the mass ratio of steam explosion kudzu root and water, adjust the pH value to be 8 , filtered after leaching at normal temperature for 30 minutes; the filtrate is concentrated to a soluble solid content greater than or equal to 10% under the condition of vacuum degree-0.08Mpa and temperature of 60°C, and then the volume ratio of the concentrated solution and 95% ethanol is 1: 3.75 Add 95% ethanol or add absolute ethanol according to the volume ratio of the concentrated solution and absolute ethanol as 1:3.0, and centrifuge after standing for 1 hour; 70% ethanol, reflux extraction at 75°C for 2 times, each time for 1.5h; combine the extracts, recover the ethanol at a vacuum of -0.08Mpa at 50°C, and obtain the total flavonoids extract of Pueraria radiata, and dry it to obtain the total flavonoids of Puer...

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Abstract

The invention relates to a total flavonoids extract method after steam blast treatment of kudzuvine root. Kudzuvine root is processed with steam blast treatment under the conditions of 0.5-1.0 MPa steam pressure for 2 to 4 minutes. Water is added and diffusion is carried out at pH 6-8 at normal temperature, then the leaching liquor is filtered; the total flavonoids in the filtrate is extracted byalcohol sedimentation method, and the total flavonoids in the filter residue is extracted by ethanol heating refluxing method, and the total flavonoids extraction method with steam blast under low pressure is established; kudzuvine is pretreated by using the short-time (2-4min) steam blast technique; the heat mechanism chemical action breaks the cell walls of kudzuvine tissues and destroys the structure of solid material kudzuvine, facilitating dissolution of kudzuvine effective components, improving extract rate of flavonoids.

Description

technical field [0001] The invention relates to the extraction of plant active components, in particular to a method for extracting total flavonoids in kudzu root through steam explosion treatment. Background technique [0002] Pueraria lobata is a leguminous plant, which was first recorded in "Shen Nong's Materia Medica". It is a common traditional Chinese medicine. Since the 1950s, modern medicine at home and abroad has carried out in-depth and systematic research on the medicinal components and pharmacological effects of Pueraria lobata root, showing that Pueraria lobata root has the function of increasing brain and coronary artery flow, and can be used for the treatment of cardiovascular and cerebrovascular diseases. Its main medicinal ingredient is the total flavonoids of Pueraria lobata. [0003] There are many extraction methods for the total flavonoids of Pueraria lobata. In the 1970s, the Chinese Academy of Medical Sciences prepared the total flavonoids of Puerari...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H1/08A61K36/48A61K125/00A61P43/00A61P29/00C07D311/30A61P1/12
CPCY02E50/16Y02E50/17
Inventor 付小果汪卫东陈洪章
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI