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High-efficiency single liquid drop micro-extractor and application thereof

An extraction device and a single-liquid technology, which is applied in the field of sample pretreatment in analytical chemistry, can solve problems such as limiting the scope of application and restricting the enrichment efficiency of SDME, and achieve the effects of simple operation, increased use volume, and solution to compatibility problems

Inactive Publication Date: 2008-06-11
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, limited by the contact area and adsorption force between the droplet and the tip of the microsyringe, the volume of the droplet in traditional single-droplet microextraction is generally less than 4 μL. The volume and stability of the droplet seriously restrict the enrichment efficiency of SDME and limit the Its scope of application

Method used

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  • High-efficiency single liquid drop micro-extractor and application thereof
  • High-efficiency single liquid drop micro-extractor and application thereof
  • High-efficiency single liquid drop micro-extractor and application thereof

Examples

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Embodiment 1

[0021] The present invention will be further described below in conjunction with the accompanying drawings, but the present invention is not limited to this specific example. Example 1 (Determination of estriol (E3), estradiol (E2), estrone (E1), and ethinyl estradiol (EE) four estrogens in environmental water samples by single droplet microextraction combined with HPLC)

[0022] use as figure 1 The shown two-phase microextraction device coupled extraction-HPLC analysis of estrogen in environmental water samples. The specific operation is: add 6.00mL of feed liquid and stirring magnet to the extraction bottle 2, extract 6.0μL of n-octanol with the 10μL microsyringe 1, immerse the needle tip 11 below the liquid surface, and press the piston of the microsyringe 1 , so that the extraction solvent forms a small droplet suspended on the needle tip 11, the stirring speed is 625rpm, the droplet is recovered after extraction for 50min, and directly enters the liquid chromatography fo...

Embodiment 2

[0023] figure 2 is the effect of the volume of the droplet (n-octanol receiving phase) on the extraction efficiency of estrogen, image 3 It is the HPLC diagram of the sample injection after the mixed standard solution of synthetic lake water sample and estrogen is subjected to two-phase single-droplet microextraction. After that, the enrichment factors of estriol, estradiol, estrone and ethinyl estradiol were between 247-335. The recovery rate of the synthetic river water and lake water samples is 81.2-114.9%, and the precision is between 2.9-8.2%, meeting the requirements of trace analysis. Embodiment 2 (using liquid-liquid-liquid microextraction to measure 2-methylphenol (2-MP), 2-nitrophenol (2-NP), 2,4-dichlorophenol ( 2,4-DCP) three phenolic compounds)

[0024] This embodiment adopts such as Figure 4 The three-phase liquid-liquid-liquid microextraction device shown is used for extraction-HPLC analysis of phenolic compounds in environmental water samples. The speci...

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Abstract

The invention discloses a high-efficient single drop micro-extraction device, which comprises a microinjector, an extractionflask and a mixer. Wherein, the needlepoint tail end of the microinjector is provided with a thickening part which can increase the contact area between liquid drop and the needlepoint; when the extracting agent is pushed out slowly from the microinjector, liquid drop with large volume is formed at the needlepoint to conduct single drop micro-extraction. If improving the extractionflask further, the invention also can be used in three-phase single drop micro-extraction. The invention has simple processing, convenient operation and high upgrading efficiency, which not only keeps the advantages of traditional single drop micro-extraction integrating separating, upgrading and sampling, but also increases the volume of liquid drop, improve the stability of liquid drop, and is convenient for being used with other analytical instruments, suitable for the separating and upgrading of the trace amount organic matter in environment, food, medicine, organism and other complex samples.

Description

technical field [0001] The invention belongs to the technical field of sample pretreatment in analytical chemistry, and in particular relates to an efficient and practical single-droplet micro-extraction device, which is suitable for the separation and enrichment of trace organic matter in complex samples such as environment, food, medicine and biology. Background technique [0002] Liquid phase microextraction (LPME) is a sample pretreatment technology that integrates sampling, separation, enrichment, and sample injection. Because of its high extraction efficiency, fast sensitivity, and environmental friendliness, LPME is widely used in the environment, food, Separation and enrichment of trace organics in complex samples such as medicine and biology. Liquid phase microextraction techniques include single droplet microextraction (SDME), hollow fiber liquid phase microextraction (HF-LPME), stirred bar microextraction (SBME), continuous flow microextraction (CFME) and liquid-l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/34
Inventor 李攻科肖小华胡玉玲尹怡周小南
Owner SUN YAT SEN UNIV
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