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Containing medicament soft capsule for treating gynecology disease and preparing method thereof

A technology of soft capsules and capsules, which is applied in the fields of diseases, capsule delivery, and pharmaceutical formulations, etc. It can solve the problems of unqualified disintegration of soft capsules, leakage of content components, migration of capsule substances, etc., and achieve satisfactory clinical efficacy and stable quality , high efficacy

Active Publication Date: 2008-06-18
江苏万高药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The present invention provides a soft capsule containing Penyanjing extract as an active ingredient, which successfully solves the common problems of current soft capsule preparations, such as disintegration prolonging over time, and It can significantly enhance the beneficial effect of Penyanjing, and has significant stability and therapeutic advantages compared with current marketed products
[0010] The object of the present invention is to provide a kind of Penyanjing soft capsule pharmaceutical preparation, especially the soft capsule preparation containing Penyanjing, which overcomes the defects of existing Penyanjing oral preparations, and overcomes the disintegration that often occurs in soft capsules Poor stability issues such as unqualified, substance migration in the capsule, active ingredient sedimentation, and content ingredient leakage, and enhanced the beneficial effect of Penyanjing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Embodiment 1: the preparation of potyanjing extract

[0093] Take 1250g of honeysuckle, 1250g of spatholobus, 1250g of dog ridge, 500g of dandelion, 500g of motherwort, 500g of plantain, 300g of red peony root, 300g of chuanxiong, add 8 times the amount of water to decoct, combine the decoction, and filter , the filtrate is concentrated to a relative density of 1.2 to 1.4, added with a certain concentration of ethanol, stirred evenly, left to stand, filtered to collect the supernatant, recovered ethanol, concentrated into a thick paste, and dried to obtain the potyanjing extract.

Embodiment 2

[0095] Bonyanjing Extract: 0.125g

[0096] Salad oil: 0.33g

[0097] Micropowder silica gel: 0.005g

[0098] Beeswax: 0.015g

[0099] Hydrogenated palm oil: 0.025g

[0100]

[0101] Make 1 capsule (0.5g)

[0102] Preparation Process

[0103] Get the Penyanjing extract in Example 1, add the prescribed amount of micropowdered silica gel, mix well, and pulverize to a fine powder that can pass through a 200-mesh sieve at least, and set aside.

[0104] Take the prescribed amount of salad oil, add beeswax and hydrogenated palm oil, heat to melt the suspending agent, add the above fine powder of Penyanjing extract mixed with micropowder silica gel, stir again, pass through a colloid mill, if there are bubbles, add an appropriate amount After adding defoamer, it is compressed into soft capsule.

Embodiment 3

[0106] Bonyanjing Extract: 0.125g

[0107] Canola oil: 0.43g

[0108] Micropowder silica gel: 0.05g

[0109] Beeswax: 0.01g

[0110] Hydrogenated palm oil: 0.02g

[0111] Soy lecithin: 0.015g

[0112]

[0113] Make 1 capsule (0.65g)

[0114] Preparation Process

[0115] Get the Penyanjing extract in Example 1, add the prescribed amount of micropowder silica gel, mix well, and pulverize to a fine powder that can pass through a 180-mesh sieve at least, and set aside.

[0116] Take the prescribed amount of rapeseed oil, add beeswax and hydrogenated palm oil, heat to melt the suspending agent, let cool to about 45°C, add soybean lecithin and stir evenly, add the fine powder of the above-mentioned Penyanjing extract mixed with micronized silica gel powder, stir again evenly, pass through a colloid mill, if there are bubbles, add an appropriate amount of defoamer, and press into soft capsules.

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PUM

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Abstract

The invention provides a new formulation of Penyanjing---soft capsule, wherein, the invention comprises matrix, suspending agent, wetting agent and gum acacia, the soft capsule can overcomes the problems of disintegration and delay existing in the current preparation, meanwhile, the invention can also obviously enhance the functional effects of Penyanjing preparation and has more outstanding stability and treating advantages compared with the current on-sale products.

Description

technical field [0001] The invention relates to a drug soft capsule preparation containing extracts of honeysuckle, spatholobus and the like, which can significantly enhance the beneficial effect of the preparation. Background technique [0002] The current marketed dosage form of Penyanjing is granules, which can treat chronic pelvic inflammatory disease. It is prepared from the eight herbs of honeysuckle, spatholobus, dog ridge, dandelion, motherwort, plantain, red peony root and chuanxiong, after water extraction and alcohol precipitation, adding appropriate amount of auxiliary materials. The shortcomings of the preparation of granules are clear at a glance. Each oral administration is 12g, and the dosage is large. It needs to be boiled with boiling water before taking it, and the medicine itself is very bitter. Inconvenient to carry, etc. can easily lead to poor compliance of patients; and the granules are not easy to store, and are easy to absorb moisture and become mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/68A61K9/48A61K47/12A61K47/14A61K47/44A61P15/00
Inventor 姚俊华
Owner 江苏万高药业股份有限公司
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