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Soft capsule containing micropowder silicagel and preparing method

A technology of micropowder silica gel and soft capsules, which is applied in the direction of medical preparations containing active ingredients, medical preparations with non-active ingredients, capsule delivery, etc. It can solve the problems of active ingredient settlement, soft capsule disintegration failure, capsule material migration, etc. problem, to achieve an effect of enhanced beneficial effect, significant stability and therapeutic advantage

Active Publication Date: 2011-11-30
江苏万高药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The present invention provides a soft capsule containing Yinzhihuang extract as an active ingredient, which successfully solves the common problems commonly existing in current soft capsule preparations, such as disintegration prolongs over time, and also It can significantly enhance the beneficial effect of Yinzhihuang, and has significant stability and therapeutic advantages compared with current marketed products
[0013] The object of the present invention is to provide a Yinzhihuang soft capsule pharmaceutical preparation, especially a soft capsule preparation containing Yinzhihuang, which overcomes the defects of the existing Yinzhihuang oral preparations, and overcomes the disintegration that often occurs in soft capsules Poor stability problems such as unqualified, substance migration in the capsule, active ingredient sedimentation, and content ingredient leakage, and enhance the beneficial effect of Yinzhihuang

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] Example 1: Preparation of four extracts from Yinzhihuang extract

[0111] Preparation of Yinchen extract: Take the Yinchen, add water and decoct three times, the first time is 1.5 hours, the second and the third time are 1 hour each, the decoction is combined, filtered, and the filtrate is concentrated to 2g of crude drug per ml, and ethanol is added Make the alcohol content reach 70%, refrigerate for 24 hours, filter, and recover ethanol from the filtrate to 5g of crude drug per ml, then add ethanol to make the alcohol content reach 85%, refrigerate for 24 hours, filter, and recover ethanol from the filtrate to 10g of crude drug per ml , Add about 5 times the amount of water, refrigerate for 48 hours, filter, concentrate the filtrate into a thick paste, and dry in vacuum to obtain the Phyllanthus chinensis extract.

[0112] Preparation of gardenia extract: take the gardenia, crush it into coarse powder, add water and decoc three times, the first and second times each for 1 ...

Embodiment 2

[0116] Yinchen extract: 0.06g

[0117] Gardenia extract: 0.032g

[0118] Baicalin: 0.2g

[0119] Honeysuckle extract: 0.04g

[0120] Soybean oil: 0.245g

[0121] Micronized silica gel: 0.05g

[0122] Beeswax: 0.005g

[0123] Hydrogenated palm oil: 0.01g

[0124] Soybean Lecithin: 0.008g

[0125] Make 1 capsule (0.65g)

[0126] Preparation Process

[0127] Take the Cymbidium extract, the gardenia extract, the baicalin and the honeysuckle extract in Example 1 and add the prescription amount of micro-powdered silica gel. After mixing uniformly, pulverize to a fine powder that can pass through at least a 200-mesh sieve for use.

[0128] Take the prescription amount of soybean oil, add beeswax and hydrogenated palm oil, heat to melt the suspending agent, stir evenly, let cool to about 35 degrees, add soybean phospholipids, and stir evenly; add the above Yinzhihuang extract mixed with micronized silica gel Stir the fine powder again, pass it through a colloid mill, if there are bubbles, add an appr...

Embodiment 3

[0130] Yinchen extract: 0.06g

[0131] Gardenia extract: 0.032g

[0132] Baicalin: 0.2g

[0133] Honeysuckle extract: 0.04g

[0134] Corn oil: 0.35g

[0135] Micronized silica gel: 0.01g

[0136] Beeswax: 0.02g

[0137] Hydrogenated coconut oil: 0.02g

[0138] Soy lecithin: 0.02g

[0139] Make 1 capsule (0.75g)

[0140] Preparation Process

[0141] Take the Cymbidium extract, the gardenia extract, the baicalin and the honeysuckle extract in Example 1 and add the prescription amount of micro-powder silica gel. After mixing uniformly, pulverize to at least a fine powder that can pass through a 180-mesh sieve for use.

[0142] Take the prescription amount of corn oil, add beeswax and hydrogenated coconut oil, heat to melt the suspending agent, stir evenly, let cool to about 50 degrees, add soybean phospholipid, and stir evenly; add the above Yinzhihuang extract mixed with micronized silica gel Stir the fine powder again, pass it through a colloid mill, if there are bubbles, add an appropriate am...

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PUM

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Abstract

The invention provides a soft capsule- a new dosage form of Yizhihuang. The active ingredients contained in the capsule include herbel artemisiae capillaris extracts, Gardenia extracts, honeysuckle extracts and baicalin; the inactive ingredients include stroma, silica gel micro powder and suspending agent. The soft capsule of the invention can remarkably improve the good effects of the Yizhihuang preparation and has better stability and more curative advantages than current products in the market.

Description

Technical field [0001] The present invention relates to a Yinzhihuang soft capsule preparation containing Yinchen extract, gardenia extract, honeysuckle extract and baicalin, which can significantly enhance the beneficial effects of the preparation. Background technique [0002] Yinzhihuang is composed of four components: Yinchen extract, gardenia extract, honeysuckle extract and baicalin. Modern pharmacology has also proved that Yinzhihuang has the effects of clearing away heat and detoxifying, removing dampness and jaundice, reducing jaundice and reducing GPT (glutamate aminotransferase). It is clinically used in the treatment of acute and chronic hepatitis and type I severe hepatitis, as well as the comprehensive treatment of other severe hepatitis. [0003] At present, the clinical application of Yinzhihuang dosage forms are mainly oral and injection, and oral preparations are mainly provided for medicinal use in the form of oral liquid, granules or tablets, such as Yinzhihuan...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K9/48A61K47/04A61K47/44A61P1/16A61P31/14A61P31/20
Inventor 沈志强姚俊华
Owner 江苏万高药业股份有限公司
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