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Soft capsule for hepatitis and preparation method thereof

A technology of soft capsules and Yinzhihuang, which is applied in the field of Yinzhihuang soft capsule preparations, can solve the problems of active ingredient sedimentation, soft capsule disintegration, leakage of content components, etc., to achieve enhanced beneficial effects and significant stability and the effect of therapeutic advantage

Active Publication Date: 2012-09-12
江苏万高药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The present invention provides a soft capsule containing Yinzhihuang extract as an active ingredient, which successfully solves the common problems commonly existing in current soft capsule preparations, such as disintegration prolongs over time, and also It can significantly enhance the beneficial effect of Yinzhihuang, and has significant stability and therapeutic advantages compared with current marketed products
[0014] The purpose of the present invention is to provide a Yinzhihuang soft capsule pharmaceutical preparation, especially a soft capsule preparation containing Yinzhihuang, which overcomes the defects of the existing Yinzhihuang oral preparations, and overcomes the disintegration that often occurs in soft capsules Poor stability problems such as unqualified, substance migration in the capsule, active ingredient sedimentation, and content ingredient leakage, and enhance the beneficial effect of Yinzhihuang

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] Example 1: Preparation of four kinds of extracts in Yinzhihuang extract

[0120] Preparation of capillary extract: take capillary, add water and decoct three times, the first time is 1.5 hours, the second and third time are 1 hour each, combine the decoction, filter, the filtrate is concentrated to contain 2g of crude drug per ml, add ethanol Make the alcohol content reach 70%, refrigerate for 24 hours, filter, recover ethanol from the filtrate to contain 5g of crude drug per ml, add ethanol to make the alcohol content reach 85%, refrigerate for 24 hours, filter, recover ethanol from the filtrate to contain 10g of crude drug per ml , add about 5 times the amount of water, refrigerate for 48 hours, filter, the filtrate is concentrated into a thick paste, and vacuum-dried to obtain the capillary extract.

[0121] Preparation of gardenia extract: Take gardenia, crush it into a coarse powder, add water to decoct three times, the first and second times each for 1 hour, and t...

Embodiment 2

[0125] Capillary extract: 0.06g

[0126] Gardenia Extract: 0.032g

[0127] Baicalin: 0.2g

[0128] Honeysuckle Extract: 0.04g

[0129] Soybean oil: 0.22g

[0130] Tween-80: 0.05g

[0131] Beeswax: 0.02g

[0132] Hydrogenated palm oil: 0.02g

[0133] Soy lecithin: 0.008g

[0134] Make 1 capsule (0.65g)

[0135] Preparation Process

[0136] Take the prescribed amount of Tween-80 and soybean lecithin, stir well until the mixture is uniform, and use it as spare solution 1.

[0137] Take the capillary extract, gardenia extract, baicalin and honeysuckle extract in Example 1, grind them into fine powders that can pass through a 200 mesh sieve, add them to the above-mentioned standby solution 1, fully disperse and stir evenly, and the dispersion time must not Less than 20 minutes, as stock solution 2.

[0138] Take the prescribed amount of soybean oil, add beeswax and hydrogenated palm oil, heat to melt the suspending agent, stir evenly, let cool to about 50 degrees; pour th...

Embodiment 3

[0140] Capillary extract: 0.06g

[0141] Gardenia Extract: 0.032g

[0142] Baicalin: 0.2g

[0143] Honeysuckle Extract: 0.04g

[0144] Corn oil: 0.31g

[0145] Tween-80: 0.04g

[0146] Beeswax: 0.04g

[0147] Hydrogenated coconut oil: 0.01g

[0148] Soy lecithin: 0.02g

[0149] Make 1 capsule (0.75g)

[0150] Preparation Process

[0151] Take the prescribed amount of Tween-80 and soybean lecithin, stir well until the mixture is uniform, and use it as spare solution 1.

[0152] Take the capillary extract, gardenia extract, baicalin and honeysuckle extract in Example 1, grind them into fine powders that can pass through a 180 mesh sieve, add them to the above-mentioned standby solution 1, fully disperse and stir evenly, and the dispersion time must not Less than 20 minutes, as stock solution 2.

[0153] Take the prescribed amount of corn oil, add beeswax and hydrogenated coconut oil, heat to melt the suspending agent, stir evenly, let cool to about 45 degrees; pour the...

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PUM

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Abstract

The invention provides a new dosage form of Yinzhihuang: soft capsules, wherein, active ingredient of substance of the soft capsules comprises Artemisia capillaria extract, gardenia extract, honeysuckle extract and baicalin; non-active ingredient comprises matrix, liquid wax and suspending agent. The liquid wax takes up 5percent-85 percent of the weight of the matrix. The soft capsules can prominently enhance the beneficial effect of the Yinzhihuang preparation which is provided with more prominent stability and treatment advantage than products on sale.

Description

technical field [0001] The invention relates to a Yinzhihuang soft capsule preparation containing capillary extract, gardenia extract, honeysuckle extract and baicalin, which can significantly enhance the beneficial effect of the preparation. Background technique [0002] Yinzhihuang preparation is composed of capillary extract, gardenia extract, honeysuckle extract and baicalin. Modern pharmacology has also proved that Yinzhihuang has the functions of clearing away heat and detoxification, promoting dampness and jaundice, reducing jaundice and reducing GPT (glutalanine aminotransferase). It is clinically used for the treatment of acute and chronic hepatitis and type I severe hepatitis, as well as comprehensive treatment of other severe hepatitis. [0003] Currently, the dosage forms of Yinzhihuang in clinical application are mainly oral and injection. Oral preparations are mainly provided for medicinal purposes in the form of oral liquid, granules or tablets, such as Yinzh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/744A61K47/02A61K47/14A61K47/44A61P1/16A61P31/14A61P31/20
Inventor 姚俊华韩立宾
Owner 江苏万高药业股份有限公司