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Nano sheet hydroxyapatite and glutin composite material and preparation

A hydroxyapatite and nano-sheet technology, applied in the field of biomedical materials, can solve the problems of easy agglomeration, difficult to disperse, limit the mechanical properties of hydroxyapatite composite materials, etc. applied effect

Inactive Publication Date: 2008-08-13
TIANJIN UNIV
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Problems solved by technology

Nano-hydroxyapatite particles are very prone to agglomeration due to their large surface energy, and it is difficult to fully disperse them
This largely limits the content of hydroxyapatite in the composite and the improvement of the mechanical properties of the composite.

Method used

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  • Nano sheet hydroxyapatite and glutin composite material and preparation

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] Add 1.0 g of layered hydroxyapatite powder with an interlayer distance of 3.1 nm into a beaker (see CN101058416 for the preparation method), and add a small amount of deionized water. Stir at room temperature for 3 hours to obtain a uniformly dispersed hydroxyapatite emulsion. Weigh 2 g of gelatin particles to prepare a gelatin transparent solution with a concentration of 6%. The gelatin solution was first added into a three-neck flask, and the temperature was raised to 73° C. using a constant temperature magnetic stirring heating mantle. Under stirring, the above-mentioned hydroxyapatite emulsion was added to the gelatin solution. The reaction was stirred at 73 °C for 4 h. Pour the reaction product into an evaporating dish. Vacuum dry at 70°C for 4h.

[0018] Grind the obtained product into powder and pass through a 120-mesh sieve. Carry out XRD test, Fig. 1 is X-ray small-angle diffraction pattern, Fig. 2 is X-ray large-angle diffraction pattern.

[0019] Test r...

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Abstract

The present invention relates to a composite material of nano patch shape hydroxylapatite and glutin, and a method for preparing the same. The composite material is prepared from hydroxylapatite and glutin as raw materials, and proportioning weight rate of hydroxylapatite and glutin is 1:2-4. The preparing method includes steps as follows: mixing the emulsion of patch shape hydroxylapatite with glutin transparent solution and reacting 3-5h in 70-75 degrees celsius, vacuum drying 3-5 hours in 70-75 degrees celsius; the hydroxylapatite content reaches more than 33%, and has 5.8-6.3 nm patch shape structure space. The hydroxylapatite and glutin can reach nanometre scale composite, and can achieve the goal of simulating natural bone tissue structure and improving various capabilities of hydroxylapatite as bone tissue substituting material. The composite has simple preparing method and low cost, and has has great significance on improvement the recovery and substituting functions of hydroxylapatite in bone tissure.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a composite material of nano-flaky hydroxyapatite and gelatin and a preparation method. Background technique [0002] In recent years, with the development of nanotechnology and material composite technology, artificial bone repair materials have also made rapid progress. Artificial bone materials not only require good biocompatibility, but also be able to form osseointegration with natural bone tissue, so that the implanted material can perform corresponding physiological functions for a long time. As the main inorganic component of natural bone, hydroxyapatite material has attracted much attention and developed rapidly because of its excellent osteoconductivity and osseointegration ability. However, pure hydroxyapatite has low strength and poor toughness. So far, hydroxyapatite itself cannot be used as a load-bearing implant, and its medical applications are limited to small...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/12A61L27/22
Inventor 万怡灶左桂福刘超罗红林何芳
Owner TIANJIN UNIV
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