Calciparine/sodium salt nano oral preparation and preparation technique thereof
An oral preparation, heparin calcium technology, applied in blood diseases, extracellular fluid diseases, pharmaceutical formulations, etc. The effect of good absorption rate, good stability and long metabolism time
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Embodiment 1
[0028] Embodiment 1: Preparation of low molecular weight heparin calcium nanoliposomes
[0029] Chitosan 1g is dissolved in the acetic acid solution 50mL of 0.1% concentration (w / w), obtains chitosan solution, filters, gets filtrate, and in the filtrate drips concentration is 1% (w / w) under magnetic stirring. Low-molecular-weight heparin calcium (Changzhou Tianpu Pharmaceutical Co., Ltd., batch number H1999007) aqueous solution until a milky white precipitate appears, the resulting suspension is centrifuged, and the precipitate is freeze-dried to obtain low-molecular-weight heparin calcium nanoliposomes. The encapsulation efficiency is as high as 98% (97.94±1.33%).
Embodiment 2
[0030] Embodiment 2: Preparation of low-molecular-weight heparin calcium nanoliposomes
[0031] Chitosan 1g is dissolved in the acetic acid solution 50mL of 2% concentration, obtains the chitosan solution of acidification, filters, gets filtrate, and in the filtrate, drips the low molecular weight heparin calcium (Changzhou Tennessee) that concentration is 20% in the filtrate under magnetic stirring General Pharmaceutical Co., Ltd., batch number H1999007) aqueous solution until a milky white precipitate appears, the resulting suspension is centrifuged, and the precipitate is freeze-dried to obtain low-molecular-weight heparin calcium nanoliposomes, and its nano-encapsulation efficiency is as high as 98% (98.06 ±1.10%).
Embodiment 3
[0032] Embodiment 3: Preparation of low molecular weight heparin calcium nanocapsules
[0033] The low-molecular-weight heparin calcium nano-liposomes obtained by the method in Example 1 were evenly divided into 20 enteric-coated capsules to obtain the low-molecular-weight heparin calcium nanocapsules with a drug content of 50 mg / capsule.
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