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Spiral tube membrane and preparation and application thereof

A technology of tube membrane and spinal cord, applied in the fields of medicine, medical biomaterials and medical tissue engineering, can solve the problems of paraplegia that is difficult to repair, paraplegia is difficult to cure, and the effect is not good.

Active Publication Date: 2012-09-05
许和平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Paraplegia is difficult to repair due to the invasive growth of glial cells and other non-nervous system tissues, preventing the regeneration of damaged spinal cord nerve tissue, and causing degeneration and degeneration of undamaged normal spinal cord tissue.
To sum up, for paraplegic patients caused by traumatic spinal cord injury, even if they are treated with surgery in the early stage, the effect is often not good, and paraplegia is difficult to cure.

Method used

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  • Spiral tube membrane and preparation and application thereof
  • Spiral tube membrane and preparation and application thereof
  • Spiral tube membrane and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]Make type I collagen into collagen suspension with a concentration of 0.5%, pour it into an open tubular mold, and freeze vertically at a speed of 1 mm / min at -80 degrees Celsius to form a composite that meets the requirements. The loose collagen inner layer of the collagen tubule;

[0039] Make type I collagen into a 10% collagen suspension, inject it into the above-mentioned open tubular mold with loose collagen, and freeze it vertically at -80 degrees Celsius at a slow speed of 1 mm / min. Sub-freezing to form a dense collagen outer layer that meets the requirements of the composite collagen tube membrane

[0040] The prepared loose collagen inner layer and dense collagen outer layer are compounded and conventionally freeze-dried to make a composite collagen tube membrane;

[0041] The type I collagen is made into a collagen suspension with a concentration of 5%, injected into a conventional freeze-drying apparatus, and frozen routinely to form a sheet-like collagen fi...

Embodiment 2

[0043] Make type I collagen into a 10% collagen suspension, pour it into an open tubular mold, and freeze vertically at a slow speed of 1 mm / min at -100 degrees Celsius to form a composite that meets the requirements. The loose collagen inner layer of the collagen tubule;

[0044] Make type I collagen into a collagen suspension with a concentration of 0.5%, inject it into the above-mentioned open tubular mold with loose collagen, and freeze it vertically at -100 degrees Celsius at a slow speed of 2 mm / min. Sub-freezing to form a dense collagen outer layer that meets the requirements of the composite collagen tube membrane

[0045] The prepared loose collagen inner layer and dense collagen outer layer are compounded and conventionally freeze-dried to make a composite collagen tube membrane;

[0046] The type I collagen is made into a collagen suspension with a concentration of 1%, injected into a conventional freeze-drying apparatus, and routinely frozen to form a sheet-like c...

Embodiment 3

[0048] Make type I collagen into a 5% collagen suspension, pour it into an open tubular mold, and freeze it vertically at a rate of 1 mm / min at -90 degrees Celsius to form a composite that meets the requirements. The loose collagenous inner layer of the collagen tubule.

[0049] Make type I collagen into a collagen suspension with a concentration of 5%, inject it into the above-mentioned open tubular mold that retains loose collagen, freeze vertically at a speed of 2 mm / min at -90 degrees Celsius, and Freeze twice to make it form a dense collagen outer layer that meets the requirements of the composite collagen tube membrane.

[0050] The prepared loose collagen inner layer and dense collagen outer layer are combined and freeze-dried to make a composite collagen tube membrane.

[0051] The type I collagen is made into a collagen suspension with a concentration of 0.5%, injected into a conventional freeze-drying apparatus, and conventionally frozen to form a sheet-like collage...

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Abstract

The invention discloses a spinal cord periosteum, a preparation method and application of the spinal cord periosteum. The spinal cord periosteum is formed by compound collagen periosteum and periosteum membrane, and is prepared by I type collagen protein. The invention can be used for protecting damaged part of spinal cord, and ensure the regeneration of the backbone nervous tissue of the damagedspinal cord, and promote the compound collagen periosteum to form a new spinal cord tissue.

Description

technical field [0001] The invention relates to the technical fields of medicine, medical biomaterials and medical tissue engineering, in particular to a spinal cord membrane, its preparation method and application. Background technique [0002] At the end of the 20th century, with the rapid development of holistic medicine, cell biology, molecular biology, genetics and tissue engineering also continued to progress and develop. Biomaterials with good properties are also being rapidly discovered and utilized. The rapid rise of tissue engineering in clinical medicine in recent years proves this point. Tissue engineering products using type I collagen as a carrier have achieved remarkable development and application. For example, the Chinese patent No. 021212779, the patent titled medical collagen material and its manufacturing process, discloses a high-purity medical collagen material, which is hereby cited in its entirety as a reference. Using bovine tendon tissue as the b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L27/40A61L27/56
Inventor 许和平
Owner 许和平
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