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Pharmaceutical composition for treating children's wind-heat cold, preparation method and quality control method

A wind-heat-cold and composition technology, which is applied in the field of pharmaceutical composition, preparation method and quality control, and can solve the problems that Western medicine cannot achieve rapid and significant curative effect, etc.

Active Publication Date: 2008-09-24
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine has no side effects in treating children with colds, but it cannot achieve the characteristics of rapid and remarkable curative effect of western medicines. Therefore, it is very necessary to provide a Chinese medicine composition preparation that can quickly and effectively treat children with wind-heat and cold.

Method used

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  • Pharmaceutical composition for treating children's wind-heat cold, preparation method and quality control method
  • Pharmaceutical composition for treating children's wind-heat cold, preparation method and quality control method
  • Pharmaceutical composition for treating children's wind-heat cold, preparation method and quality control method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0181] Daqingye 150g Banlangen 90g Honeysuckle 90g Forsythia 90g Gardenia 90g

[0182] Moutan bark 90g Scutellaria baicalensis 90g Bamboo leaves 60g Earthworm 60g Chonglou 45g

[0183] Bupleurum 90g Baiwei 60g

[0184] The above twelve flavors, the peony bark, Bupleurum, forsythia steam distillation , collect the distillate, the dregs and other nine flavors such as Folium Folium, add water and decoct twice, each time for 1 hour, combine the decoction, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol content 70%, let it stand . Take the supernatant to recover ethanol, concentrate to about 200ml, add water, stir well, let stand, take the supernatant, filter, and concentrate the filtrate to an appropriate amount. Take another 400g of sucrose to make syrup, combine it with the above liquid medicine and distillate, add appropriate amount of corrective agent and preservative, adjust the total amount to 1000ml, stir well, filter, pot, and ...

Embodiment 2

[0194] Embodiment 2 suppositories

[0195] Daqingye 190g Banlangen 70g Honeysuckle 130g

[0196] Forsythia 70g Gardenia 50g Peony bark 130g

[0197] Scutellaria baicalensis 110g Bamboo leaves 90g Earthworm 30g

[0198] Aescin 75g Bupleurum 110g Baiwei 30g

[0199] For the above twelve flavors, distill Moutan Cortex, Bupleurum, and Forsythia with water steam, collect the distillate, add medicinal residues and other nine flavors such as Folium Folium and decoct twice, each time for 1 hour, combine the decoction, filter, Concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol content 70%, and let stand. Take the supernatant to recover ethanol, concentrate to about 200ml, add water, stir well, let stand, take the supernatant, filter, concentrate the filtrate, and vacuum dry. Take an appropriate amount of semi-synthetic fatty acid (Type 34 or Type 36) as the suppository base, mix it with the distillate and melt it on a water bath, add the above-mentio...

Embodiment 3

[0200] Embodiment 3 Dispersible tablets

[0201] Daqingye 220g Banlangen 60g Honeysuckle 150g

[0202] Forsythia 60g Gardenia 50g Peony bark 140g

[0203] Scutellaria baicalensis 130g Bamboo leaves 100g Earthworm 40g

[0204] Aescin 85g Bupleurum 130g Bai Wei 40g.

[0205] For the above twelve flavors, distill Moutan Cortex, Bupleurum, and Forsythia with water steam, collect the distillate, add medicinal residues and other nine flavors such as Folium Folium and decoct twice, each time for 1 hour, combine the decoction, filter, Concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol content 70%, and let stand. Take the supernatant to recover ethanol, concentrate to about 200ml, add water and stir evenly, let stand, take the supernatant, filter, concentrate the filtrate, vacuum dry, pulverize, add appropriate amount of dextrin and sodium carboxymethyl starch (3% ~ 7% %), granulate, dry, granulate, sieve out part of the fine particles, spray into th...

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Abstract

The invention discloses a drug composition for curing children wind-heat type common cold, a preparation method and a quality control method. The drug composition of the invention comprises the raw medicines of dyers woad leaf, radix isatidis, honeysuckle, forsythia, gardenia, moutan bark, baikal skullcap root, bamboo leaves, earthworm, Chinese Paris rhizome, radix bupleuri and cynanchum atratum. The preparation method is as follows: the moutan bark, the radix bupleuri and the forsythia are distilled by vapor, the distilment is collected, the dregs of a decoction and the remaining nine traditional Chinese medicines such as the dyers woad leaf are decocted with water to merge a decoction liquid and are filtered, a filter liquor is concentrated and is let stand with ethanol; a clear solution is taken to recycle ethanol and is concentrated as well as is mixed with water and let stand, the clear solution is taken to be filtered, the filter liquor is concentrated to the appropriate amount; saccharose is taken to make into syrup which is mixed with the liquid medicine and the distilment, the mixture after being added with appropriate amount of flavor agent and preservative is evenly stirred, filtered, encapsulated and sterilized, and the drug composition is made. The drug composition adopts the effective liquid chromatography to detect the content of the chlorogenic acid. The drug composition of the invention has good curative effect on the treatment of children wind-heat type common cold.

Description

technical field [0001] The invention relates to a pharmaceutical composition, a preparation method and a quality control method, in particular to a pharmaceutical composition for treating children with wind-heat-cold, a preparation method and a quality control method. Background technique [0002] Colds and respiratory infections are one of the most common diseases in children and can occur throughout the year. Pediatric cold medication should be particularly cautious, as many cold medicines for adults are harmful to children. Such as "Suxiao Ganfeng Capsule", "Ganmaotong", "Antongding" and other medicines contain paracetamol, phenacetin, aminopyrine, caffeine and other ingredients. These components can inhibit the bone marrow hematopoietic system, affect the production and growth of blood cells in children, lead to leukopenia and agranulocytosis, reduce the immunity of children, and some can cause toxic liver damage. At present, there are many medicines for treating colds...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P31/00A61P29/00G01N30/90G01N30/02A61K35/64A61K35/62
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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