Method for preparing D-phenylalanine

A phenylalanine and process technology, applied in the field of synthesis of unnatural amino acids, can solve problems such as low enzyme activity

Active Publication Date: 2008-10-22
山东奥博生物科技有限公司
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  • Abstract
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Problems solved by technology

This method does not require racemization, but there is no mature method for synthesizing DL-phenylalanine; 3. Hydantoinase directly enzymatically synthesizes D-phenylalanine. This method is currently only in the laboratory because of its low enzyme activity. stage

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  • Method for preparing D-phenylalanine
  • Method for preparing D-phenylalanine
  • Method for preparing D-phenylalanine

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Embodiment Construction

[0014] The specific embodiments of the present invention will be further described below in conjunction with the accompanying drawings.

[0015] refer to figure 1 , the present invention takes L-phenylalanine 1 as the main raw material, through racemization process A, resolution process B, double salt crude product refining process C, refined salt dissolution reaction process D, finished product refining process E, respectively according to the variety and The solvent and auxiliary materials are added in doses, and the compound reaction is carried out under specific temperature, environment and time conditions, and D-phenylalanine 12 is finally formed. Add L-phenylalanine 1, solvent 2, and racemization agent 3 in the process of racemization process A, add pure water 4 after mixing, precipitate solvent 2 after racemization treatment, add ethanol 11 to wash after water distillation, and obtain DL -Phenylalanine6. Mix pure water 4 and hydrochloric acid 5 into a hydrochloric aci...

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Abstract

The invention relates to a preparation method of D-phenylalanine which takes L-phenylalanine (1) as the main raw material, adopts equipments, such as a reactor, a filter (L), a centrifuge (X), a vacuum drier (G), etc., adds solvent and chemical auxiliary materials according to the ratio of species and dose and then carries out chemosynthesis at the given temperature, environment and time. DL-phenylalanine (6) is generated by recemization technique (A). Complex salt crude product (8) of the D-phenylalanine is generated by splitting technique (B). Refined salt (10) of the D-phenylalanine is generated by refining technique (C) of the complex salt crude product. Splitting agent (7) is separated by the lysogenic response (D) of the refined salt. Finally, the D-phenylalanine (12) is made by the process flow of refined product technology. The method meets the needs of the environment protection without producing the pollution of three wastes, guarantees the quality, improves the yield and makes progress in research and development of chemical synthesis of the D-phenylalanine (12).

Description

technical field [0001] The present invention relates to unnatural amino acid, especially relates to the synthetic method of unnatural amino acid. Background technique [0002] D-Phenylalanine is an important pharmaceutical and pesticide intermediate, widely used in medicine, pesticide, food, feed and other fields. At present, only a few domestic manufacturers produce D-phenylalanine, and the specific production processes are as follows: 1. Fermentation-aminoacylase split method, which requires the use of L-phenylalanine produced by fermentation as raw material , after racemization, acetylation and other processes, and then hydrolyzed with aminoacylase to produce. The process of this method is relatively mature, and there are ready-made enzyme preparations, but the production cost is relatively high; 2. Utilize the chemical synthesis process to produce DL-phenylalanine, and then carry out chemical resolution. This method does not require racemization, but there is no mature...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/36C07C227/36
Inventor 曹俊山郝秀利潘维民王淑华刘俊红
Owner 山东奥博生物科技有限公司
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