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Use of Tulathromycin compound for curing respiratory disease of fowl
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A technology of toramectin and compounds, which is applied in the field of macrolide antibiotics, and can solve problems such as the reduction of therapeutic effect
Inactive Publication Date: 2008-11-05
TIANJIN SHENGJI GRP CO LTD
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Abstract
Description
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Problems solved by technology
In my country, tylosin and tilmicosin are currently widely used macrolides. Although the use of these two drugs has achieved good results, with the prolongation of use time, in many Different degrees of drug resistance have emerged in different regions, and the dosage is increasing, but the therapeutic effect is gradually decreasing
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0010] Chicken flocks naturally infected with respiratory diseases were randomly divided into three groups with 100 chickens in each group.
[0011] The first group was injected intramuscularly with tolamectin at a dose of 3 mg / kg;
[0012] The second group was treated with tilmicosin at a normal dose for 3 consecutive days;
[0013] The third group did not use any drugs.
[0014] Results: A single intramuscular injection of tolamycin at a dose of 3 mg / kg in 100 chickens naturally infected with respiratory diseases had the same effect as continuous application of tilmicosin for 3 days. However, it is stronger than the therapeutic effect of tilmicosin, which has been administered continuously for 2 days.
Embodiment 2
[0016] Chicken flocks naturally infected with respiratory diseases were randomly divided into three groups with 100 chickens in each group.
[0017] The first group was injected intramuscularly with tolamectin at a dose of 3 mg / kg;
[0018] The second group was treated with florfenicol at a normal dose for 3 consecutive days;
[0019] The third group did not use any drugs.
[0020] Results: A single intramuscular injection of tolamycin at a dose of 3 mg / kg to treat 100 chickens naturally infected with respiratory diseases has the same effect as continuous application of florfenicol for 3 days. However, it is stronger than the therapeutic effect of florfenicol, which has been administered continuously for 2 days.
Embodiment 3
[0022] Chicken flocks naturally infected with respiratory diseases were randomly divided into three groups with 100 chickens in each group.
[0023] The first group was injected intramuscularly with tolamectin at a dose of 3 mg / kg;
[0024] The second group was treated with Jinhua Pingchuan powder according to the normal amount for 5 consecutive days;
[0025] The third group did not use any drugs.
[0026] Results: A single intramuscular injection of 3 mg / kg tolamycin in 100 chickens naturally infected with respiratory diseases had the same effect as continuous application of Jinhua Pingchuan San for 5 days. However, it is stronger than the therapeutic effect of Jinhua Pingchuan San, which has been used continuously for 3 days.
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Abstract
The invention discloses an application of a tulathromycin compound in the treatment for avian respiratory diseases, and the tulathromycin compound is prepared into an injection (the content in the formulation is 100mg / ml, once a day, 3mg / kg for each time of intramuscular injection). The tulathromycin is an effective drug for prevention and treatment for gallinaceous respiratory diseases by the method of single-doseintramuscular injection for drug administration. At the same time, the times of animal treatments are reduced to the minimal times, thus obtaining the maximum compliance and further reducing the stresses to the animals.
Description
technical field [0001] The present invention relates to the field of macrolide antibiotics, more specifically, relates to the application of toramectin compounds in treating poultry respiratory diseases. Background technique [0002] Erythromycin has been widely used in the treatment of animal diseases since it was used in the United States in 1952. However, erythromycin has several important defects, such as irregular absorption, instability in gastric acid, short half-life, gastrointestinal irritation and narrow antibacterial spectrum, and obviously no antibacterial activity against Haemophilus influenzae; and erythromycinErythromycin is only effective against actively dividing bacteria, and many Gram-negative bacilli are inherently resistant to erythromycin because they cannot effectively pass through the outer membrane of their bacteria. Therefore, a new drug is urgently needed to replace them. In my country, tylosin and tilmicosin are currently widely used macrolides...
Claims
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Application Information
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