Method for preparing 7-phenylacetamido-3-chloromethyl-4-carboxylic acid p-m-ethoxybenzyl ester

Abstract

The invention discloses a method for preparing 7-phenylacetamido-3-chloromethyl-4-carboxylic acid p-meth-oxybenzyl ester. The method comprises the following steps of: adding nitrogen heterocyclic butanone sulfinic acid which is a primary standard substance, a chlorinated solvent and a catalyst which is 1 to 5 percent of the primary standard substance by weight into a reaction kettle; starting a recycle pump to cycle materials through a film chlorinator; aerating chlorine gas into the film chlorinator by using air as a carrier to perform a chlorination reaction; stopping the aeration of the chlorine gas, and withdrawing and reclaiming chlorinated solvent, when the reaction is completed; adding a ring closure solvent and dropping a ring closed agent into the film chlorinator, and adding a pH regulator into the film chlorinator at a temperature of between 20 and 25 DEG C to regulate the pH value to between 4 and 6; keeping on stirring, feeding, centrifugalizing the materials, washing the materials with solvent, and drying to produce the product. The whole process is performed at normal temperature, thereby avoiding a harsh condition of deep cooling below 40 DEG C below zero, and facilitating the industrial operation. The method reduces the investment of a deep cooling unit, reduces the equipment investment, reduces electrical load, reduces the production cost of the product, and improves market competitiveness.

Description

The method for preparing 7-phenylacetamido-3-chloromethyl-4-cephalosporanic acid p-methoxybenzyl ester Technical field: The invention relates to a method for preparing 7-phenylacetamido-3-chloromethyl-4-cephalosporanic acid p-methoxybenzyl ester. Background technique: In the production process of 7-phenylacetamido-3-chloromethyl-4-cephalosporanic acid p-methoxybenzyl ester, chlorination is one of the key core steps of production. At present, in production, the chlorination agent produced by electrolysis of saturated sodium chloride solution is generally used, or hypochlorite is used to carry out chlorination reaction below -40°C, and then the final product is obtained in closed loop. The process conditions are harsh, the operation is complicated, and the cost is high. Invention content: The object of the present invention is to provide a kind of process condition simple, operate respectively, the method for preparing 7-phenylacetamido-3-chloromethyl-4-cephalosporanic a...

AI Technical Summary

Problems solved by technology

The process conditions are harsh, the oper

Images