Catalysis synthesis method for paranitrophenetole

A technology of nitrophenethyl ether and p-nitrophenol, which is applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of chloride pollution, cumbersome post-processing of products, and long reaction cycle, etc. separate simple effects

Inactive Publication Date: 2008-12-03
JIANGSU POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of these methods have the disadvantages of long reaction cycle, low efficiency, environmental pollutio

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The active carbon impregnated with 5% potassium hydroxide place is as catalyst, and catalyst consumption is 5% of raw material quality, and raw material molar ratio p-nitrophenol: dimethyl carbonate is 10: 1, 150 ℃ of reaction temperature, reaction time is 4 hour, the p-nitrophenol conversion rate is 14.60%, and the p-nitroanisole selectivity is 100%.

Embodiment 2

[0016] The active carbon impregnated with 20% potassium hydroxide place is as catalyst, and catalyst consumption is 5% of raw material quality, and raw material molar ratio p-nitrophenol: dimethyl carbonate is 10: 1, and reaction temperature is 150 ℃, and reaction time is 4 hour, p-nitrophenol conversion rate was 74.22%, p-nitroanisole selectivity was 100%.

Embodiment 3

[0018] The active carbon impregnated with 35% potassium hydroxide place is as catalyst, and catalyst consumption is 5% of raw material quality, and raw material molar ratio p-nitrophenol: dimethyl carbonate is 10: 1, and reaction temperature is 150 ℃, and reaction time is 4 hour, the p-nitrophenol conversion rate is 57.44%, and the p-nitroanisole selectivity is 100%.

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Abstract

The invention relates to a method for catalytic synthesis of paranitrophenetole. The raw materials used by the method are green chemicals diethyl carbonate (DMC) and p-nitrophenol, and the catalyst is NaY molecular sieve, activated aluminum oxide or activated carbon which is impregnated by alkali metals or alkaline-earth metal compounds. Good conversion rate of the raw materials and good selectivity of target products can be obtained by using the method provided by the invention under given conditions; and the conversion rate of the p-nitrophenol can reach over 64 percent, and the selectivity of the paranitrophenetole can reach 100 percent. The method is superior to the prior synthetic method of homogeneous catalysis or phase-transfer catalysis; and the catalyst is simple to separate and can be reused. Moreover, the method takes the DEC as an ethylized reagent to actually realize a green synthetic route.

Description

technical field [0001] The invention relates to the field of organic chemical industry, in particular to a method for catalytically synthesizing p-nitrophenetole. Background technique [0002] p-Nitrophenetole is an important organic chemical intermediate, which is widely used in chemical production. p-Aminophenetole can be prepared by reducing p-nitrophenetole with alkali sulfide. It can be used as an intermediate for acid dyes and organic pigments, as well as a synthetic intermediate for drugs such as phenacetin and anthrax, or for the production of rubber. Auxiliary. The traditional synthesis method uses p-nitrochlorobenzene as a starting material, ethanol as an ethylating reagent, and a large amount of sodium hydroxide as a catalyst to synthesize p-nitrophenethyl ether under homogeneous or phase-transfer conditions. Most of these methods have the disadvantages of long reaction cycle, low efficiency, pollution of the environment by the generated chlorides, cumbersome po...

Claims

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Application Information

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IPC IPC(8): C07C205/37C07C201/12
Inventor 李永昕薛冰张舒乐
Owner JIANGSU POLYTECHNIC UNIVERSITY
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