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Medicinal composition for treating diabetes

A composition, diabetes technology, applied in the direction of drug combination, metabolic diseases, pharmaceutical formulations, etc., to achieve the effect of reducing toxicity

Inactive Publication Date: 2008-12-17
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the above teachings can make people think of Chinese rose and other medicines in combination to treat diabetes, the inventor has screened through a large number of tests and found that the combination of rose or its extract and taurine not only has a synergistic or additive effect on treating diabetes. Previous experimental studies have also shown that the use of taurine can also reduce the toxicity of certain Chinese rose extracts
[0007] Taurine is a sulfur-containing amino acid that exists in the human body and has a variety of physiological functions. Studies have shown that taurine has a hypoglycemic effect (Yuan Minsheng, Huang Yongqi. Analysis of the effect and curative effect of taurine on blood sugar in diabetic patients. Advances in Pharmaceutics. 1996, 20(4): 225-227; Li Hui, Li Jianchun, Inhibitory Effect of Taurine on Myocardial Renin-Angiotensin System in Diabetic Rats. Chinese Journal of Endocrinology and Metabolism. 1997, 13(2) : 108-110; Zhang Neng, Zhang Hui. Protective effect of taurine on islet β cells of streptozotocin diabetic rats. Chinese Journal of Diabetes. 1998, 6(1): 30-33), there is no Chinese rose yet Related reports on combined use of flower extract and taurine

Method used

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  • Medicinal composition for treating diabetes
  • Medicinal composition for treating diabetes
  • Medicinal composition for treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: the composition of medicine for treating diabetes

[0026] 1. Prescription: 10 parts of Chinese rose extract, 10 parts of taurine

[0027] 2. Extraction method of rose flower extract: use 12 times the amount of 30% ethanol to reflux extract twice, each time for 1 hour, combine the extracts, recover the ethanol and concentrate to an appropriate amount, centrifuge, add to the processed AB-8 type macroporous adsorption resin, eluted with water and 50% ethanol solution in sequence, collected the ethanol eluate, recovered the ethanol and concentrated to an appropriate amount, spray-dried and pulverized to obtain the rose flower extract.

[0028] 3. Weigh the rose flower extract and taurine of the prescribed amount, add pharmaceutically acceptable auxiliary materials, and prepare any commonly used dosage form with conventional Chinese medicine preparation methods.

Embodiment 2

[0029] Embodiment 2: the composition of medicine for treating diabetes

[0030] 1. Prescription: 10 parts of Chinese rose extract, 20 parts of taurine

[0031] 2. Extraction method of rose flower extract: use 12 times the amount of 50% ethanol to reflux to extract twice, each time for 1 hour, combine the extracts, recover the ethanol and concentrate to an appropriate amount, centrifuge, add to the processed AB-8 type macroporous adsorption resin, eluted with water and 50% ethanol solution in turn, collected the ethanol eluate, recovered ethanol, concentrated into a thick paste, dried under reduced pressure, and pulverized to obtain the rose flower extract.

[0032] 3. Weigh the rose flower extract and taurine of the prescribed amount, add pharmaceutically acceptable auxiliary materials, and prepare any commonly used dosage form with conventional Chinese medicine preparation methods.

Embodiment 3

[0033] Embodiment 3: the composition of medicine for treating diabetes

[0034] 1. Prescription: 10 parts of Chinese rose extract, 30 parts of taurine

[0035] 2. Extraction method of rose flower extract: use 12 times the amount of 85% ethanol to reflux extract twice, each time for 1 hour, combine the extracts, recover the ethanol and concentrate to an appropriate amount, centrifuge, add to the processed X-5 type macroporous adsorption resin, eluted with water and 30% ethanol solution successively, collected the ethanol eluate, recovered the ethanol and concentrated to an appropriate amount, sprayed dried, and pulverized to obtain the rose flower extract.

[0036] 3. Weigh the rose flower extract and taurine of the prescribed amount, add pharmaceutically acceptable auxiliary materials, and prepare any commonly used dosage form with conventional Chinese medicine preparation methods.

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Abstract

The invention relates to a pharmaceutical composition for treating diabetes. The pharmaceutical composition mainly comprises Chinese rose flower extract and taurine, and cam also comprises berberine. Pharmacodynamic test and acute toxicological test indicate that the addition of taurine not only increases the efficacy of the Chinese rose flower extract, but also decreases the toxicity thereof.

Description

technical field [0001] The present invention relates to a composition for treating diabetes, in particular to a pharmaceutical composition mainly composed of rose flower or its extract and taurine, and using the pharmaceutical composition of rose flower or its extract and taurine to treat diabetes or combine Diabetic patients, and preparations of the pharmaceutical composition. technical background [0002] Diabetes is a metabolic disease with multiple etiologies. With the improvement of people's living standards and changes in diet structure and lifestyle, the incidence of diabetes is increasing day by day. According to incomplete statistics, there are nearly 30 million people with diabetes in my country, and the number is growing at a rate of 700,000 people every year. There are many types of diabetes, which can be mainly divided into type I and type II diabetes. Type I is insulin-dependent, and patients need to rely on insulin injections to control blood sugar; Type II ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/738A61P3/10A61K31/185A61K31/4375
Inventor 蔡东晨张宏武张福军李清娟赵倩刘海丽肖乔张彦玲何颖娜杨汉煜
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD