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Jinshile in-situ-forming eye gel

A technology of gel and happy eyes, applied in the field of ready-to-form gel for myopia happy eyes, can solve the problems of complicated implementation process, expensive pharmaceutical excipients, etc., and achieve the effects of prolonging the residence time, improving the curative effect, and having no adverse irritating reactions.

Inactive Publication Date: 2008-12-31
肖正连
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the patent uses poloxamer 407 and 188, which are very expensive pharmaceutical excipients, and the implementation process of the invention is also relatively complicated, so further research and development of a new ophthalmic instant gel process is required

Method used

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  • Jinshile in-situ-forming eye gel
  • Jinshile in-situ-forming eye gel
  • Jinshile in-situ-forming eye gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Prescription: Zijinlong Extract 1g Hydrochloric Acid (0.15mol / L) 400ml

[0027] Sodium Citrate 17.6g Methylcellulose 5.0g Phenylethyl Alcohol 0.5g

[0028] Ethanol 5ml Sodium Chloride 5.0g PEG-1000 20g

[0029] PEG-400 5 grams water for injection Appropriate amount

[0030] Preparation method: Heat water for injection to boil, cool to 80°C, add Zijinlong extract, dissolve phenylethyl alcohol in ethanol, add dropwise to the above solution while stirring, add sodium citrate, stir for more than 30 minutes, then add hydrochloric acid After stirring, filter through a microporous membrane (0.22μm), heat the filtrate to 40°C, add sodium chloride, methylcellulose, PEG-1000 and PEG-400 while hot, and stir to room temperature (18-25°C ), add water for injection to make up the weight to 1000 milliliters, stir to make it form a uniform gel, and aseptically pack it.

Embodiment 2

[0032] Prescription: 3 grams of Zijinlong extract, 200 ml of sulfuric acid (0.15mol / L)

[0033] Sodium Citrate 17.6g Methylcellulose 5.0g Benzyl Alcohol 0.5g

[0034] Ethanol 5ml Sodium Chloride 1.5g PEG-1000 70g

[0035] Appropriate amount of water for injection

[0036] Preparation method: Heat water for injection to boil, cool to 80°C, add Zijinlong extract, dissolve benzyl alcohol in ethanol, add dropwise to the above solution while stirring, add sodium citrate, stir for more than 30 minutes, then add sulfuric acid After stirring, filter through a microporous membrane (0.22μm), heat the filtrate to 40°C, add sodium chloride, methylcellulose and PEG-1000 while hot, stir to room temperature (18-25°C), and add Make up the weight with water for injection to 1000 ml, stir to make it form a uniform gel, and aseptically pack it.

Embodiment 3

[0038] Prescription: Zijinlong Extract 5g Sodium Hydroxide (0.1mol / L) 200ml

[0039] Boric acid 5.6g Methylcellulose 5.0g Sodium benzoate 0.5g

[0040] Ethanol 5ml Sodium Chloride 5.0g PEG-4000 100g

[0041] Appropriate amount of water for injection

[0042] Preparation method: heat and boil water for injection, cool to 80°C, add Zijinlong extract, sodium citrate, sodium hydroxide and sodium benzoate, stir for more than 30 minutes, then add boric acid and stir, pass through a microporous membrane ( 0.22μm) and filter, then heat the filtrate to 40°C, add PEG-4000 and methylcellulose while hot, stir to room temperature (18-25°C), add water for injection to make up the weight to 1000ml, stir to form a uniform The gel is aseptically dispensed.

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PUM

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Abstract

The invention discloses a ready gel benefiting myopic eyes and the preparation method thereof, 1 litre of the ready gel benefiting myopic eyes of the invention contains: 1-10g of dactylicapnos root extractive, 0.05-1g of preservative, 1.0-7.5g of osmotic pressure regulator, 30-150g of gel substrate and the rest is acid-bases buffer and injection water. The invention enriches the dosage forms for benefiting myopic eyes, greatly prolongs the detention time of drugs in eyes, improves the treatment effect and has no bad stimulation reaction due to optimizing the accessories and improving the technique.

Description

【Technical field】 [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to an instant gel for myopia and happy eyes. 【Background technique】 [0002] Ophthalmic instant gel is also called ophthalmic in-situ gel or ophthalmic in-situ gel. Its preparation is liquid when placed at room temperature. Gel-like, it can stay in the eye for a long time, so as to prolong the treatment time, enhance the treatment effect and reduce the loss of medicine. [0003] Instant ophthalmic gel is not yet a very mature pharmaceutical preparation, and instant ophthalmic gel, which depends on the principles of temperature, pH value and ionic strength, is not yet mature in commercialization, because the dosage form is not only It requires fine technology, appropriate excipients, and the proper matching of drugs, processes and excipients in ophthalmic ready-to-use gels. Otherwise, it cannot be placed in a liquid state at room temperature, and ...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K9/00A61K47/32A61K47/34A61K47/38A61P27/10A61K125/00A61K47/10
Inventor 肖正连
Owner 肖正连