Vitamin U, belladonna and aluminium complex type capsules and preparation method thereof

A composite, capsule technology, applied in the field of medicine, can solve the problems of poor stability of vitamin U belladonna aluminum capsules, unsuitable for long-term storage, etc., and achieve the effects of avoiding interaction, prolonging shelf life and improving stability.

Inactive Publication Date: 2009-01-07
BEIJING HUAANFO BIOMEDICAL RES CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to solve the defects of poor stability of the existing vitamin U belladonna aluminum capsules, which are not suitable for long-term storage, and provide a vitamin U belladonna aluminum composite capsule preparation, which combines chemical components vitamin U (including vitamin UII) and hydrogen oxidized Aluminum is separated from the traditional Chinese medicine ingredient belladonna extract (including belladonna extract) to prepare a vitamin U belladonna aluminum compound capsule preparation, which can improve and make up for its original defects

Method used

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  • Vitamin U, belladonna and aluminium complex type capsules and preparation method thereof
  • Vitamin U, belladonna and aluminium complex type capsules and preparation method thereof
  • Vitamin U, belladonna and aluminium complex type capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Preparation of Vitamin U Belladonna Aluminum Compound Capsules (1000 capsules)

[0032] Formula composition:

[0033] Vitamin U 50g

[0034] Aluminum hydroxide 140g

[0035] Belladonna extract 10g

[0036] Starch

[0037] Microcrystalline cellulose

[0038] 5% PVP-water solution

[0039] Micronized silica gel

[0040] Magnesium stearate

[0041] Weigh 50 g of vitamin U, 140 g of aluminum hydroxide, an appropriate amount of starch and an appropriate amount of microcrystalline cellulose, and mix them with 5% PVP aqueous solution, add magnesium stearate, and fill 1000 capsules on a common capsule filling machine.

[0042] Weigh 10 g of dried belladonna extract, add appropriate amount of finely powdered silica gel and magnesium stearate, mix well, and put it into a dosage tray on a special hard capsule filling machine.

[0043] The capsule and the capsule containing the belladonna extract powder are locked together on a special hard capsule filling machine to complet...

Embodiment 2

[0044] Example 2: Preparation of Vitamin U Belladonna Aluminum Compound Capsules (1000 capsules)

[0045] Formula composition:

[0046] Vitamin U 50g

[0047] Aluminum hydroxide 140g

[0048] Belladonna extract 10g

[0049] Starch

[0050] Microcrystalline cellulose

[0051] 5% PVP-water solution

[0052] Micronized silica gel

[0053] Magnesium stearate

[0054]Weigh 50g of vitamin U, mix with appropriate amount of starch and appropriate amount of microcrystalline cellulose, and granulate with 5% PVP aqueous solution; weigh 140g of aluminum hydroxide, mix with appropriate amount of starch and appropriate amount of microcrystalline cellulose, and granulate with 5% PVP aqueous solution. The granules are mixed uniformly, magnesium stearate is added, and 1000 capsules are filled in an ordinary capsule filling machine.

[0055] Weigh 10 g of dried belladonna extract, add appropriate amount of finely powdered silica gel and magnesium stearate, mix well, and put it into a dosage tray on...

Embodiment 3

[0057] Example 3: Accelerated Test of Vitamin U Belladonna Aluminum Compound Capsule

[0058] Put the prepared vitamin U belladonna aluminum composite capsules into plastic bottles, and take samples for accelerated experiments.

[0059] The sample was placed in a constant temperature and humidity drying box and stored under the conditions of a temperature of 40° C. and a relative humidity of 75%. The sample was subjected to an accelerated test for 6 months. Samples were taken in 1, 2, 3, and June to investigate the properties and content. The accelerated test results are shown in Table 2.

[0060] Table 2 Accelerated Test Results of U Belladonna Aluminum Compound Capsules

[0061]

[0062] Note: It is stipulated in the quality standard that the vitamin U content of this product should be 90.0%-110.0% of the labeled amount; the aluminum hydroxide containing aluminum hydroxide shall be calculated as alumina, and shall not be less than 45.0% of the labeled amount; the belladonna ex...

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Abstract

The invention relates to a vitamin U-belladonna-aluminum compound type capsule preparation, which has two capsular spaces. The chemical components of vitamin U and aluminum hydroxide are mixed and pelletized, or respectively pelletized and further mixed, then, packed into one capsular space of a compound type capsule; and the dry belladonna extractive is packed into the other capsular space of the compound type capsule, thereby realizing the separation of the pharmaceutical chemicals and the traditional Chinese medicine, greatly improving the stability of the capsule preparation and prolonging the storage life. The invention further relates to the preparation method of the vitamin U-belladonna-aluminum compound type capsule preparation. The invention further relates to the application of the vitamin U-belladonna-aluminum compound type capsule preparation in preparing the protective medicament of gastrointestinal mucosa and the medicament of anti-canker. The invention belongs to the field of medicine.

Description

Technical field [0001] The present invention relates to a vitamin U belladonna aluminum composite capsule preparation. The preparation has two cavities. The chemical ingredients vitamin U and aluminum hydroxide are mixed and granulated or separately granulated and then mixed, and then filled into one of the compound capsules. In the cavity, the dried belladonna extract is put into the other cavity of the compound capsule to realize the separation of chemical medicine and traditional Chinese medicine, which greatly improves the stability of the medicine. The invention also relates to a preparation method of vitamin U belladonna aluminum composite capsule preparation. The invention belongs to the field of medicine. Background technique [0002] Vitamin U Belladonna Aluminum Capsules currently on the market mainly include Vitamin U Belladonna Aluminum Capsules (Weidening), Vitamin U Belladonna Aluminum Capsules II (Sidasu), and Vitamin U Belladonna Aluminum Capsules III. Vitamin U B...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K9/48A61P1/04A61K33/08A61K31/198A61J3/00
Inventor 林雅军李华王文艳陈明侠刘平徐希平
Owner BEIJING HUAANFO BIOMEDICAL RES CENT
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