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Instant gel rubber of thyroxine liothyronine for eyes

A technology for liothyronine and thyroxine, which is applied in the field of thyroxine liothyronine ophthalmic ready-to-use gel, can solve the problems of complicated implementation process, expensive pharmaceutical excipients, etc., and achieves optimized process, prolonged residence time, rich Effects of pharmaceutical dosage forms

Inactive Publication Date: 2009-01-14
肖正连
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the patent uses poloxamer 407 and 188, which are very expensive pharmaceutical excipients, and the implementation process of the invention is also relatively complicated, so further research and development of a new ophthalmic instant gel process is required

Method used

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  • Instant gel rubber of thyroxine liothyronine for eyes
  • Instant gel rubber of thyroxine liothyronine for eyes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Prescription: Thyroid Powder Extract 0.1g Hydrochloric Acid (0.05mol / L) 400ml

[0023] Sodium Citrate 9.1g Methylcellulose 5.0g Phenylethyl Alcohol 0.5g

[0024] Ethanol 5ml Sodium Chloride 1.0g PEG-1000 20g

[0025] PEG-400 5g water for injection appropriate amount

[0026] Preparation method: heat water for injection to boil, cool to 80°C, add thyroid powder extract, dissolve phenylethyl alcohol in ethanol, add dropwise to the above solution while stirring, add sodium citrate, stir for more than 30 minutes, then add hydrochloric acid After stirring, filter through a microporous membrane (0.22μm), heat the filtrate to 40°C, add sodium chloride, methylcellulose, PEG-1000 and PEG-400 while hot, and stir to room temperature (18-25°C ), add water for injection to make up the weight to 1000 milliliters, stir to make it form a uniform gel, and aseptically pack it.

Embodiment 2

[0028] Prescription: 1 g of thyroid powder extract, 200 ml of sulfuric acid (0.05mol / L)

[0029] Sodium Citrate 9.1g Methylcellulose 5.0g Benzyl Alcohol 0.5g

[0030] Ethanol 5ml Sodium Chloride 2.0g PEG-1000 70g

[0031] Appropriate amount of water for injection

[0032] Preparation method: Heat water for injection to boil, cool to 80°C, add thyroid powder extract, dissolve benzyl alcohol in ethanol, add dropwise to the above solution while stirring, add sodium citrate, stir for more than 30 minutes, then add sulfuric acid After stirring, filter through a microporous membrane (0.22μm), heat the filtrate to 40°C, add sodium chloride, methylcellulose and PEG-1000 while hot, stir to room temperature (18-25°C), and add Make up the weight with water for injection to 1000 ml, stir to make it form a uniform gel, and aseptically pack it.

Embodiment 3

[0034] Prescription: Thyroid Powder Extract 1.5g Sodium Hydroxide (0.1mol / L) 200ml

[0035] Boric acid 5.6g Methylcellulose 5.0g Sodium benzoate 0.5g

[0036] Ethanol 5ml Sodium Chloride 1.0g PEG-4000 100g

[0037] Appropriate amount of water for injection

[0038] Preparation method: heat and boil water for injection, cool to 80°C, add thyroid powder extract, sodium citrate, sodium hydroxide and sodium benzoate, stir for more than 30 minutes, then add boric acid and stir, pass through a microporous membrane ( 0.22μm) and filter, then heat the filtrate to 40°C, add PEG-4000 and methylcellulose while hot, stir to room temperature (18-25°C), add water for injection to make up the weight to 1000ml, stir to form a uniform The gel is aseptically dispensed.

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Abstract

The invention discloses an immediate type ophthalmic gelatin of thyroxine liothyronine and a preparation method thereof. 100 milliliters of the immediate type ophthalmic gelatin of thyroxine liothyronine contains 0.1 to 3 grams of thyroxine powder extract, 0.05 to 1 gram of preservative, 1.0 to 7.5 grams of permeation pressure conditioning agent and 30 to 150 grams of gelatin substrate. Remaining components are acid-base buffer regent and water for rejection. The invention enriches the dosage forms of the thyroxine powder extract by optimizing auxiliary materials and improving technology so that lag time in eyes is greatly prolonged and curative effect is improved without adverse stimulus reaction.

Description

【Technical field】 [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a thyroxine-liothyronine ophthalmic ready-to-use gel. 【Background technique】 [0002] Ophthalmic instant gel is also called ophthalmic in-situ gel or ophthalmic in-situ gel. Its preparation is liquid when placed at room temperature. Gel-like, it can stay in the eye for a long time, so as to prolong the treatment time, enhance the treatment effect and reduce the loss of medicine. [0003] Instant ophthalmic gel is not yet a very mature pharmaceutical preparation, and instant ophthalmic gel, which depends on the principles of temperature, pH value and ionic strength, is not yet mature in commercialization, because the dosage form is not only It requires fine technology, appropriate excipients, and the proper matching of drugs, processes and excipients in ophthalmic ready-to-use gels. Otherwise, it cannot be placed in a liquid state at room temperature, and it...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K35/55A61K9/00A61K47/32A61K47/34A61K47/38A61P27/12A61K47/10
Inventor 肖正连
Owner 肖正连
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