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Kukoline intravenous transfusion preparation

A technology for sinomenine and intravenous administration, which is applied in the direction of anti-inflammatory agents, drug delivery, non-central analgesics, etc., can solve problems such as hindering application and drug efficacy, improve clinical application safety, avoid adverse reactions, The effect of promoting widespread application

Active Publication Date: 2009-01-21
李蕴麟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0023] From the above studies, it can be seen that the rapid release of histamine and the rapid drop in blood pressure of the drug have two pharmacological effects that lead to various adverse reactions, which hinder the use of the drug in diseases of multiple joints, multiple organs, and multiple parts of the body. Application and efficacy

Method used

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  • Kukoline intravenous transfusion preparation
  • Kukoline intravenous transfusion preparation
  • Kukoline intravenous transfusion preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Sample preparation method: Take 0.3g of sinomenine hydrochloride, 0.0005g of disodium edetate, 0.016g of sodium sulfite, and 9g of sodium chloride, dissolve them in an appropriate amount of water for injection, heat to 80°C, add an appropriate amount of activated carbon for injection, and keep warm After 15 minutes, filter out the activated carbon, and after fine filtration with a microporous membrane, add water for injection from the filter to 1000ml, fill it into 250ml / bottle, and sterilize it to obtain. A total of 200 bottles were prepared. The concentration of sinomenine is 0.03wt%

[0043] Usage: Intravenous infusion, 250ml each time, 1-2 times a day.

Embodiment 2

[0045] Sample preparation method: take 0.6g of sinomenine hydrochloride, 0.0005g of disodium edetate, 0.016g of sodium sulfite, and 9g of sodium chloride, dissolve them in an appropriate amount of water for injection, heat to 80°C, add an appropriate amount of activated carbon for injection, and keep warm After 15 minutes, filter out the activated carbon, and after fine filtration with a microporous membrane, add water for injection from the filter to 1000ml, fill it into 250ml / bottle, and sterilize it to obtain. A total of 200 bottles were prepared. The concentration of sinomenine is 0.06wt%.

Embodiment 3

[0047] Sample preparation method: Take 1.0g of sinomenine hydrochloride and 50g of glucose, dissolve them in an appropriate amount of water for injection, heat to 80°C, add an appropriate amount of activated carbon for injection, keep warm for 20 minutes, filter out the activated carbon, and fine filter through a microporous membrane, Add water for injection from the filter to 1000ml, fill to 250ml / bottle, and sterilize to get ready. A total of 200 bottles were prepared. The concentration of sinomenine is 0.1wt%

[0048] Usage: Intravenous infusion, 250ml each time, 1-2 times a day or as directed by the doctor.

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Abstract

The invention provides a sinomenine injection special for intravenous administration. The sinomenine injection is an injection which comprises 0.005-0.3wt% of sinomenine and an aqueous solvent for injection, or an injection which comprises sterile injection powder or lyophilized injection powder used for preparation just before injection to cause the sinomenine concentration to be 0.005-0.3wt% in the injection and the aqueous solvent for injection. The sinomenine injection of the invention is used for treating rheumatism, chronic pain and other chronic inflammatory diseases. Compared with other existing injection forms, the sinomenine injection special for intravenous injection has lower drug adverse reaction, and the clinical curative effect is obviously improved.

Description

technical field [0001] The invention relates to a medicine for intravenous injection, in particular to an intravenous injection solution for treating rheumatism and other diseases with chronic inflammation pathological mechanism. Background technique [0002] Sinomenine (sinomenine) is one of the alkaloids extracted from the stem and root of Sinomenium acutum (Thunb.) R. et Wils., a plant of Fangjiaceae, and is a known medicinal substance. Modern pharmacological studies have shown that sinomenine has a variety of pharmacological effects. In a nutshell, the main pharmacological effects of sinomenine known so far are as follows: anti-inflammatory, immunosuppressive, antihypertensive, central inhibitory, antiarrhythmic, etc. [0003] Sinomenine hydrochloride has the following pharmacological effects: [0004] 1. Anti-inflammatory effect: can inhibit acute exudation and chronic proliferative inflammation; can significantly inhibit the increase of 5-HT vascular permeability, in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/485A61P29/00A61P37/00A61P9/12
Inventor 李蕴麟
Owner 李蕴麟
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