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Carboxymethyl mycose moisture absorption humectant and preparing method thereof

A technology of carboxymethyl seaweed and humectant, which is applied in the field of daily chemicals, can solve the problems of high extraction cost, inability to chemically synthesize, and failure to meet market needs, etc., and achieve high moisture absorption and moisturizing performance, strong anti-radiation and moisturizing functions, and low cost Effect

Active Publication Date: 2011-04-13
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the resource of trehalose is more extensive than that of hyaluronic acid, it is still a high value-added product, which cannot be chemically synthesized, and the extraction cost is relatively high
Due to the above reasons, trehalose cannot meet the needs of the market, and through appropriate chemical modification, obtaining new trehalose derivatives, thereby improving its activity, and reducing the amount of trehalose is one of the effective methods to solve this problem

Method used

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  • Carboxymethyl mycose moisture absorption humectant and preparing method thereof
  • Carboxymethyl mycose moisture absorption humectant and preparing method thereof
  • Carboxymethyl mycose moisture absorption humectant and preparing method thereof

Examples

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Embodiment 1

[0014] A hygroscopic and moisturizing agent of carboxymethyl trehalose: carboxymethyl trehalose is used as a component of the hygroscopic and moisturizing agent.

[0015] The preparation of the carboxymethyl trehalose of described hygroscopic humectant: 3g trehalose (see figure 1 ) was added to 30mL isopropanol and stirred and swelled at room temperature for 20min. During this period, 10mol / L NaOH solution was added in 6 times, 1mL each time, once every 4min, and stirred for 40min after the last addition to obtain basic trehalose. Chloroacetic acid was added in 5 times, once every 5 minutes. After the addition was completed, the reaction was stirred at 40°C for 3h, filtered with suction, then washed with 30mL of methanol, filtered with suction, and dried at 50°C to obtain carboxymethyl trehalose (see figure 2 ).

Embodiment 2

[0017] The difference from Example 1 is:

[0018] Preparation of carboxymethyl trehalose: add 3g trehalose to 40mL isopropanol, stir and swell at room temperature for 30min, add 10mol / L NaOH solution 5 times during the period, 1.6mL each time, once every 4min, and stir for 30min after the last addition. To obtain basic trehalose, add 4 g of solid chloroacetic acid in 4 times, once every 4 minutes, stir and react at 35°C for 4 hours after the addition, filter with suction, wash with 30mL of methanol, filter with suction, and dry at 55°C. Carboxymethyl trehalose was obtained.

Embodiment 3

[0020] The difference from Example 1 is that trehalose swollen by alkaline isopropanol solution with a molar mass ratio of 1:4 is reacted with chloroacetic acid in excess alkaline isopropanol solution at 55°C for 2.5 h, and then washed with methanol, suction filtered, and dried at 60°C to obtain carboxymethyl trehalose. Among them, chloroacetic acid was added into the trehalose in 4 times, with an interval of 5 minutes between each time. The trehalose swollen by alkaline isopropanol solution is to stir and swell trehalose by alkaline isopropanol solution at room temperature for 30 minutes, wherein the amount of alkaline isopropanol solution is 15 times the mass volume of trehalose, and the alkaline The isopropanol solution is isopropanol with a volume ratio of 5:1 and sodium hydroxide with a concentration of 10 mol / L, wherein sodium hydroxide is added to the isopropanol in 4 times with an interval of 5 minutes each time.

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Abstract

The invention relates to the domestic chemical field and the pharmaceutical industry, in particular to a moisture absorption humectant of carboxymethyl mycose and a method for preparing the same. The moisture absorption humectant of carboxymethyl mycose uses carboxymethyl mycose as the moisture absorption humectant. The preparation method is as follows: according to the mol ratio of between 1:4 and 6, mycose undergoing swelling by the alkali isopropyl alcohol solution and chloroacetic acid are mixed and reacted in the excessive alkali isopropyl alcohol solution at a temperature of between 30 and 60 DEG C for 2 to 5h, and the mixture is subjected to suction filtering and drying so as to obtain the moisture absorption humectant of carboxymethyl mycose. In the invention, carboxymethyl mycoseis obtained by the effective synthetic method, and the production cost is only slightly increased, but the moisture-absorption and moisture-retention performances are obviously improved; as a highly efficient moisture-absorption and moisture-retention factor, carboxymethyl mycose obtained by the method of the invention is hopeful to replace hyaluronic acid to be used in cosmetics.

Description

technical field [0001] The invention relates to the field of daily chemicals and the pharmaceutical industry, in particular to a hygroscopic and moisturizing agent of carboxymethyl trehalose and its preparation. Background technique [0002] Hyaluronic acid has strong hydrophilicity and exhibits very good moisturizing performance. It is the substance with the best moisturizing performance found in nature at present. Its water retention value is as high as 500ml / g, which is better than glycerin, propylene glycol, sorbitol, Moisturizers such as polyethylene glycol, lactic acid, and sodium pyrrolidone carboxylate are recognized as the most ideal natural moisturizing factors by the international cosmetics industry. Today, there are more and more high-end cosmetics with hyaluronic acid added in the cosmetics market at home and abroad. Cosmetics containing hyaluronic acid are known as "bionic cosmetics", and cosmetics with hyaluronic acid have become mainstream products in the int...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/60A61Q1/00C07H3/04
Inventor 郭占勇杨少丽周少燕周玉玲苗凤萍
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI