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Nimodipine solid dispersed formulation and preparation method thereof

A nimodipine solid and dispersed technology, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve problems such as slow disintegration and dissolution, failure to take effect in time, and fluctuations in clinical curative effect

Inactive Publication Date: 2009-01-28
TIANJIN CENT PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nimodipine is insoluble in water, and the clinical efficacy of existing tablets fluctuates. Due to poor solubility, disintegration and dissolution are slow, and it cannot take effect in time, with low bioavailability and poor therapeutic effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Nimodipine 20 servings

[0051] Povidone K30 30 servings

[0052] 3 parts sodium lauryl sulfate

[0053] Hypromellose 25 servings

[0054] 3 parts of cross-linked polyvinylpyrrolidone

[0055] 15 parts of low-substituted hydroxypropyl cellulose

[0056] Lactose 50 servings

[0057] Microcrystalline Cellulose 150 servings

[0058] 100 parts of solvent

[0059] 3 parts sodium carboxymethyl starch

[0060] 3 parts croscarmellose sodium

[0061] Magnesium Stearate 0.5 part.

Embodiment 2

[0063] Nimodipine 20 servings

[0064] Povidone K30 50 servings

[0065] 10 parts sodium lauryl sulfate

[0066] Hypromellose 15 servings

[0067] Cross-linked polyvinylpyrrolidone 10 parts

[0068] Low-substituted hydroxypropyl cellulose 30 parts

[0069] Lactose 80 servings

[0070] Microcrystalline Cellulose 200 servings

[0071] 150 parts of solvent

[0072] 10 parts sodium carboxymethyl starch

[0073] Croscarmellose sodium 10 parts

[0074] Magnesium Stearate 5 parts.

Embodiment 3

[0076] Nimodipine 20 servings

[0077] Povidone K30 35 servings

[0078] 5 parts sodium lauryl sulfate

[0079] Hypromellose 13 servings

[0080] Cross-linked polyvinylpyrrolidone 5 parts

[0081] 15 parts of low-substituted hydroxypropyl cellulose

[0082] Lactose 55 servings

[0083] Microcrystalline Cellulose 150 servings

[0084] 110 parts of solvent

[0085] 3 parts sodium carboxymethyl starch

[0086] 3 parts croscarmellose sodium

[0087] Magnesium Stearate 1 part.

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PUM

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Abstract

The invention provides a nimodipine solid dispersing preparation and a preparation method thereof; the nimodipine solid dispersing preparation contains effective dose of nimodipine and pharmaceutic adjuvant which contains polyvinylpyrrolidone K30, sldium lauryl sulfate, hydroxypropyl methylcellulose, etc. After being taken orally, the dispersing preparation can quickly disintegrate and be evenly dispersed into fine particles, so as to have remarkable disintegration and leachability capacity compared with the compressed tablets, realize the rapid absorption of medicine, the function of rapid onset, and improve the bioavailability of human body.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to the improvement of the dosage form of nimodipine, more specifically to a nimodipine solid dispersion preparation and a preparation method thereof. Background technique [0002] Cerebral vasospasm is a very common problem in the clinical work of neurosurgery, and it has become an important obstacle to improve the efficacy of neurosurgery in treating cerebrovascular disease and craniocerebral injury, and to reduce complications and mortality after craniotomy. Cerebral vasospasm (CVS) refers to the abnormal constriction of arteries over a period of time. It is one of the important causes of death in patients with subarachnoid hemorrhage (SAH). [0003] The calcium channel blocker nimodipine is a drug that can effectively prevent and treat cerebral vasospasm. Nimodipine is a dihydropyridine drug, which can block the receptor-mediated calcium influx in vascular smoo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/435A61P9/10
Inventor 何光杰
Owner TIANJIN CENT PHARM CO LTD
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