Chinese medicine soft capsule for treating upper respiratory infection and preparation method as well as quality detection method thereof

A technology for upper respiratory tract and soft capsule, which can be used in capsule delivery, pharmaceutical formulations, respiratory diseases, etc., and can solve problems such as unqualified disintegration, increased gelatin cross-linking, and delamination.

Inactive Publication Date: 2013-09-11
CHONGQING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The existing traditional Chinese medicine soft capsule preparation technology still has the following problems: Oxygen and aldehydes can chemically react with gelatin, resulting in increased crosslinking, denaturation and hardening of gelatin, resulting in unqualified disintegration. Among them, aldehydes may exist in In the capsule fluid; delamination is prone to occur during storage. After delamination, the capsule fluid and the capsule material are in full contact, which can accelerate the aging of the soft capsule, which requires great attention

Method used

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  • Chinese medicine soft capsule for treating upper respiratory infection and preparation method as well as quality detection method thereof
  • Chinese medicine soft capsule for treating upper respiratory infection and preparation method as well as quality detection method thereof
  • Chinese medicine soft capsule for treating upper respiratory infection and preparation method as well as quality detection method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] 【Prescription】 Contents:

[0062] Softgel skins:

[0063] 1000 traditional Chinese medicine soft capsules are made altogether with the crude drug and pharmaceutical adjuvant of above-mentioned weight.

[0064] [Preparation method] ① Take the extract of Scutellaria baicalensis and the extract of Gardenia jasminoides, grind them separately, pass through a 90-mesh sieve, slowly add the fine powder to soybean oil in stages, mix well, add lecithin, beeswax, glycine I and cysteine 1. Mix evenly, grind and mix with colloid mill for 35 minutes to obtain liquid medicine, store it in another device, and let it stand for later use; ② Take gelatin, glycerin, sorbitol and water, put them in a colloidal sol tank, fully swell, keep warm at 65°C for 35 minutes, add Glycine II, cysteine ​​II, titanium dioxide, chocolate brown and ethyl p-hydroxybenzoate, stirred for 40 minutes, vacuum degassed for 35 minutes to obtain glue, stored in another container, kept at 50°C for later use; ③...

Embodiment 2

[0085] 【Recipe】 Contents:

[0086] Softgel skin:

[0087] 1000 traditional Chinese medicine soft capsules are made altogether with the crude drug and pharmaceutical adjuvant of above-mentioned weight.

[0088] [Preparation method] (1) Traditional Chinese medicine soft capsule: ① Take the extract of Scutellaria baicalensis and the extract of Gardenia jasminoides, grind them separately, pass through a 60-mesh sieve, and slowly add the fine powder to corn oil in stages, mix well, add carbomer, formazan Base cellulose, citric acid and sodium sulfite, mix well, grind and mix in a colloid mill for 55 minutes, store in another container, and let it stand for later use; ② Take gelatin, xylitol and water, put them in a colloidal sol tank, fully swell, and keep warm for 55 minutes at 75°C , add fumaric acid, sodium metabisulfite, zinc oxide, brown iron oxide and potassium sorbate, stir for 60 minutes, vacuum degas for 55 minutes, store in another container, and keep warm at 60°C fo...

Embodiment 3

[0106] 【Prescription】 Contents:

[0107] Softgel skins:

[0108] 1000 traditional Chinese medicine soft capsules are made altogether with the crude drug and pharmaceutical adjuvant of above-mentioned weight.

[0109] [Preparation method] (1) Traditional Chinese medicine soft capsule: ① Take the extract of Scutellaria baicalensis and the extract of Gardenia jasminoides, grind them separately, pass through an 80-mesh sieve, and slowly add the fine powder to soybean oil in stages, mix well, add lecithin, beeswax, Glycine I and cysteine ​​I were mixed evenly, and the colloid mill was ground and mixed for 45 minutes. Minutes, add glycine II, cysteine ​​II, titanium dioxide, chocolate brown and ethyl p-hydroxybenzoate, stir for 50 minutes, vacuum degass for 45 minutes, store in another container, keep warm at 55°C for later use; ③In the soft capsule unit, Use a roller to make the glue solution into a rubber plate, inject the liquid medicine into the rubber plate with a syringe...

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Abstract

The invention discloses a Chinese medicine soft capsule for treating upper respiratory infection. The Chinese medicine soft capsule is a solid preparation prepared by subjecting a radix scutellariae extract, a fructus gardeniae extract and pharmaceutic adjuvants in a proper proportion to a proper preparation process. The Chinese medicine soft capsule has the efficacies of resisting virus, killing bacteria, diminishing inflammation, relieving pain, and clearing away heat, and can be used for effectively treating the upper respiratory infection; and compared with a conventional preparation, the Chinese medicine soft capsule has the characteristics of good taste, rapid absorption, fast action, strong efficacy, convenience for taking, good adaptability and the like. The invention also discloses a preparation method of the Chinese medicine soft capsule. The invention further comprises a quality detection method of the Chinese medicine soft capsule. The quality detection method comprises the three parts of verification, inspection and content measurement. According to the quality detection method disclosed by the invention, the quality control standard of the traditional Chinese medicine soft capsule is improved, and therefore the clinical curative effect of the Chinese medicine soft capsule can be fully ensured.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine soft capsule for treating upper respiratory tract infection and its preparation and quality testing methods. Background technique [0002] Upper respiratory tract infection is the general term for nose, pharynx and laryngitis, commonly known as "cold" and "cold". It is a common and frequently-occurring disease that has a great impact on people's life, study and work. Sore throat, cough, runny nose, sneezing, body aches and swollen tonsils. [0003] Modern medicine believes that the disease is caused by bacterial or viral infection, and the infection caused by viruses and bacteria together accounts for about 90%. If it is not treated in time, it may be combined or secondary to a variety of serious infections, and even threaten humans (especially children and the elderly) s life. Western medicine is mainly based on symptomatic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K9/48G01N30/90G01N30/88A61P11/00A61P31/04A61P31/12
Inventor 姚干何宗玉王允陶勇胡霞
Owner CHONGQING UNIV OF POSTS & TELECOMM
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