Bone cement with biological decomposability and preparation method thereof

Abstract

The invention relates to a bone cement with biological decomposability and a preparation method thereof. Macromolecular poly propylene fumarate (PPF) and the double-phase material of tracalcium phosphate (TTCP) / anhydrous calcium hydrophosphate (DCPA) are mixed to derive the bone cement material with biological decomposability. The bone cement material derived by the preparation method of the invention has the advantages of syringeability, biological decomposability, radiation imperviousness, compressive strength closer to bone strength, lower polymeric temperature, high biological compatibility, etc.

Description

【Technical field】 [0001] The invention provides a biodegradable bone cement and a preparation method thereof, in particular a method of combining a polymer poly(propylene fumarate), PPF for short) and tetracalcium monophosphate (Tetracalcium phosphate, Ca 4 O(PO) 2 , referred to as TTCP) / anhydrous calcium hydrogen phosphate (Dicalcium phosphateanhydrous, CaHPO 4 , referred to as DCPA) dual-phase materials are used in combination as a bone cement material for bone defect filling, and related preparation methods. 【Background technique】 [0002] With the rise of social living standards and the advancement of medical care, it is foreseeable that the population will age, and diseases accompanied by aging, such as: osteoporosis and its derived complications, have become more of an issue affecting the elderly. A major issue in health. The most common complication of osteoporosis is vertebral compression fractures, because osteoporosis can make bones fragile and increase the r...

AI Technical Summary

Problems solved by technology

[0005] 1. The high temperature reaction caused by polymerization will cause the sensory nerve endings to be burned by high temperature

[0006] 2. Residual liquid: MMA is a toxic substance. Once leaked, it may cause venous system obstruction, which may lead to pulmonary embolism.

[0007] 3. Compared with natural bone tissue, the strength of bone cement PMMA after hardening is too large, which may cause stress concentration, resulting in secondary osteoporosis and fractures

[0008] 4. Bone cement PMMA is a non-biodegradable material, which will hinder the progress of bone remodeling; if there is leakage during the operation, it may require a second operation to remove it

[0009] 5. There is no direct bond with the bone

[0015] However, the aforementioned calcium phosphate cement (CPC) cannot meet clinical requirements because its initial strength is not strong enough.

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