32 results about "Poly(propylene fumarate)" patented technology

Compositions for delivering a pharmaceutically active agent to the eye, and/or for treating an ophthalmic disorder, are based on a fumarate polymer, especially a poly(propylene fumarate) polymer.

Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer, a crosslinking agent, and a porogen comprising biodegradable hydrogel microparticles are mixed together and allowed to form a porous scaffold in an mold or in a body cavity. Example biodegradable unsaturated polymers include poly(propylene fumarate) and poly(e-caprolactone-fumarate). The cosslinking agent may be a free radical initiator, or may include a free radical initiator and a monomer capable of addition polymerization. Example hydrogel microparticles include uncrosslinked or crosslinked collagen , an uncrosslinked or crosslinked collagen derivative, and an uncrosslinked or crosslinked synthetic biodegradable polymer such as oligo(poly(ethylene glycol) fumarate).

Poly(propylene fumarate) is copolymerized with poly(caprolactone) diol to produce a block copolymer of poly(propylene fumarate) and poly(ε-caprolactone). The biocompatible and bioresorbable block copolymer of poly(propylene fumarate) and poly(ε-caprolactone) is useful in the fabrication of injectable and in-situ hardening scaffolds for tissue and/or skeletal reconstruction. The block copolymer can be crosslinked by redox or photo-initiation, with or without an additional crosslinker. Thus, the copolymer is both self-crosslinkable (without the use of any crosslinkers) and photocrosslinkable (in the presence of UV light).

A cross-linkable monomer comprises a fumaric acid functional group having a first end and a second end, a first spacer group affixed to said first end and comprising at least repeating unit, a first terminal group affixed to said first spacer group, a second spacer group affixed to said second end and comprising at least one ethylene glycol repeating unit, and a second terminal group affixed to said second spacer group. A hydrogel formed by cross-linking the present monomer and a method for making the monomer. A method for forming a hydrogel, comprises the steps of a) synthesizing a copolymer of poly(propylene fumarate) (PPF) and poly(ethylene glycol (PEG) so as to produce P(PF-co-EG), b) synthesizing a PEG-tethered fumarate (PEGF), c) coupling agmatine sulfate to the PEGF to produce PEGF modified with agmatine (Agm-PEGF), and d) cross-linking the P(PF-co-EG) from step a) with Agm-PEGF from step c).

The invention discloses a degradable polyurethane material with active oxygen responsiveness and a preparation method of the degradable polyurethane material. The degradable polyurethane material comprises a biodegradable polyester glycol soft segment and a hard segment composed of saturated aliphatic diisocyanate and reactive oxygen responsive small molecular diamine. The material is prepared bytaking poly(epsilon-caprolaclone glycol) (PCL) or polypropylene glycol fumarate (PPF) as macromolecular diols, saturated aliphatic diisocyanate as a raw material and reactive oxygen responsive small molecular diamine as a chain extender and adopting a two-step chain extension method. A polyurethane elastomer prepared from the degradable polyurethane material has good biocompatibility and responsiveness to reactive oxygen, the material and a degradation product are harmless to human bodies, so that the degradable polyurethane material can be widely applied to the fields such as biological medicines and tissue engineering and can be used for bone repair and myocardium generation.

The invention relates to the technical field of high polymer material synthesis, and discloses a novel crosslinkable and degradable multi-block copolymer, the chemical structural formula of which is shown as formula (I) in the specification, wherein in the formula (I), n is greater than or equal to 3 and less than or equal to 22; m+p is greater than or equal to 4 and less than or equal to 110; andm, n and p are positive integers. The preparation method of the novel crosslinkable and degradable multi-block copolymer comprises the following steps of: uniformly mixing polypropylene fumarate andpoly(trimethylene carbonate), and carrying out reaction at 150-170DEG C for 4-6h to obtain the copolymer. The physical, chemical and degradation properties of the novel crosslinkable and degradable multi-block copolymer provided by the invention can be adjusted by changing the molecular weights and component ratios of PPF and PTMC; oxidation-reduction or ultraviolet crosslinking curing molding canbe carried out, and the performance of a finally molded product can be flexibly regulated and controlled by regulating and controlling a polymer crosslinking network. The copolymer can be used as a tissue engineering material for bone, cartilage and nerve regeneration.

A bio-degenerable bone cement is made of a mixture of poly (propylene fumarate) (PPF) and a diphasic material of tetra-calcium phosphate (TTCP)/dicalcium phosphate anhydrous (DCPA). The bone cement produced by a manufacturing method is injectable, bio-degenerable and non-penetrable to radioactive rays and features the advantages of a compressive strength close to the strength of bones, a low polymerization temperature, and a high biological compatibility.

The invention discloses an adenine-reinforced degradable soft tissue adhesive as well as a preparation method and a use method thereof, and the preparation method comprises the following steps: step 1, putting PPF, PPF-DA and Adenine powder into a solvent, and uniformly stirring to obtain a mixture A; step 2, removing the solvent in the mixture A to obtain a mixture B; 3, adding a photoinitiator BAPO solution into the mixture B, and uniformly mixing the materials to obtain a mixture C; and step 4, removing the solvent in the mixture C to obtain the adenine-reinforced degradable soft tissue adhesive. When in use, ultraviolet light is adopted to carry out photocuring on the material. According to the invention, adenine is introduced into a poly propylene fumarate-based material in a dispersive distribution manner, and meanwhile, the bonding performance, degradation performance and biocompatibility of the material are improved. The problems that in the prior art, the adhesion strength between a PPF-based material and soft tissue is low, and application of the PPF-based material to a soft tissue adhesive is limited are solved.

The invention provides a poly-butyl glycol fumaric acid ester-based material for an environment-friendly LED packaging adhesive and a preparation method of the poly-butyl glycol fumaric acid ester-based material. A final curing product is a PBF/PPF-DA cross-linking solidified body, namely, a poly-butyl glycol fumaric acid ester/poly-butyl glycol fumaric acid ester diacrylic ester cross-linking solidified body, the solidified product is free of toxicity, the solidification time can be controlled within a relatively short time range by adjusting the lighting intensity and the distance between a light source and a sample, the requirements of LED packaging on the solidification time can be greatly met, and the solidified product is relatively good in light transmittance, refractive index, thermal stability and mechanical property.

The invention discloses a high-barrier high polymer thin-film material and a preparation method thereof. The high-barrier high polymer thin-film material comprises the following components by weight: 15-30 parts of polyethylene, 15-25 parts of polyvinyl chloride, 2-5 parts of diethyl phthalate, 2-6 parts of polycarbonate, 4-12 parts of polyvinyl alcohol, 3-6 parts of dipropylene glycol dibenzoate, 4-9 parts of poly propylene fumarate, and 3-7 parts of polypropylene glycol adipate. The preparation method comprises the following steps: high-speed mixing, screw rod extruding, film blowing modeling, cooling and the like. The prepared high-barrier high polymer thin-film material has strong airtight performance and high tensile strength, and is convenient to use, and wide in application range.

The invention discloses an absorbable cervical intervertebral fusion cage and a preparation method thereof. The fusion cage is a bionic intervertebral fusion cage made from nano-hydroxyapatite and poly propylene fumarate polymer composites; the preparation method of the fusion cage comprises the steps that a PPF/DEF mixed solution is prepared in proportion, BAPO is added, then the nano-hydroxyapatite is added, the prepared mixed solution is injected into a fusion cage polymethyl methacrylate mould, and is prepared into a fusion cage prototype after ultraviolet irradiation polymerization, and finally punching and teeth making are carried out on the fusion cage prototype. The fusion cage has bone induction activity and absorbability in vivo, can be degraded in vivo gradually until the humanbody adsorbs the fusion cage completely, the fusion situation after surgery can be observed through X ray, and the fusion cage is applied to anterior cervical intervertebral fusion fixed cases. The absorbable cervical intervertebral fusion cage and the preparation method thereof have the advantages that the preparation method is simple, a better interface combination between inorganic components and high polymer materials can be ensured, the mechanical strength of the prepared polymer is higher than that of a thermo-crosslinking method, and the mechanical strength and elasticity modulus of thepolymer are more close to cancellous bone of the human body.

The invention relates to a preparation method of a high-compatibility magnesium-based biocomposite material, and belongs to the technical field of magnesium alloy materials. According to the method, poly (propylene fumarate) is used as a raw material and as a coating porous gel to modify the surface of a magnesium alloy material. Since the porous gel is used as a carrier, a network gel structure can be effectively formed, cell adsorption specific surface area is enlarged, and a large number of cells can be accommodated, so that the carrier has a high cell capacity, and the porous structure effectively adsorbs phosphorylcholine. The phosphorylcholine is used for surface modification to significantly enhance the surface free energy and hydrophilicity of the magnesium alloy material and effectively improve the compatibility of the magnesium-based biomaterial with the cells.

In one or more embodiments, the present invention provides a low molecular weight, non-toxic, resorbable poly(ethylene glycol) (PEG)-block-poly(propylene fumarate) (PPF) diblock copolymers and poly(propylene fumarate) (PPF)-block-poly(ethylene glycol) (PEG)-block-poly(propylene fumarate) (PPF) triblock copolymers (and related methods for their making and use) that permits hydration for the formation of such things as hydrogels and has constrained and predictable material properties suitable for 3D printing and drug delivery applications. Using continuous digital light processing (cDLP) hydrogels the diblock and triblock copolymers can be photochemically printed from an aqueous solution into structures having a 10-fold increase in elongation at break compared to traditional diethyl fumarate (DEF) based printing. Furthermore, PPF-PEG-PPF triblock hydrogels have also been found in vitro to be biocompatible across a number of engineered MC3T3, NIH3T3, and primary Schwann cells.