32 results about "Poly(propylene fumarate)" patented technology

Poly(propylene fumarate) is copolymerized with poly(caprolactone) diol to produce a block copolymer of poly(propylene fumarate) and poly(caprolactone). The biocompatible and bioresorbable block copolymer of poly(propylene fumarate) and poly(caprolactone) is useful in the fabrication of injectable and in-situ hardening scaffolds for tissue and / or skeletal reconstruction. The block copolymer can be crosslinked by redox or photo-initiation, with or without an additional crosslinker. Thus, the copolymer is both self-crosslinkable (without the use of any crosslinkers) and photocrosslinkable (in the presence of photons such as UV light).

Improved methods for preparing polyethylene glycol fumarate) are disclosed. Methods for chemically crosslinking or photocross-linking hydrophilic polyethylene glycol fumarate) with hydrophobic polymers such as poly(propylene fumarate) (PPF) and poly(caprolactone fumarate) (PCLF) to form various hydrogels (FIG. 1) with controllable hydrophilicity are also disclosed. The hydrogels are useful in the fabrication of injectable and in-situ hardening scaffolds for application in skeletal reconstruction. An injectable material including the hydrogels may be useful in controlled drug release.

In one or more embodiments, the present invention provides a low molecular weight, non-toxic, resorbable poly(ethylene glycol)(PEG)-block-poly(propylene fumarate) (PPF) diblock copolymers and poly(propylene fumarate) (PPF)-block-poly(ethylene glycol)(PEG)-block-poly(propylene fumarate) (PPF) triblock copolymers (and related methods for their making and use) that permits hydration for the formationof such things as hydrogels and has constrained and predictable material properties suitable for 3D printing and drug delivery applications. Using continuous digital light processing (cDLP) hydrogelsthe diblock and triblock copolymers can be photochemically printed from an aqueous solution into structures having a 10-fold increase in elongation at break compared to traditional diethyl fumarate (DEF) based printing. Furthermore, PPF-PEG-PPF triblock hydrogels have also been found in vitro to be biocompatible across a number of engineered MC3T3, NIH3T3, and primary Schwann cells.

Method for making poly(propylene fumarate) (PPF) polymer made by ring-opening polymerization of propylene oxide and maleic anhydride in the presence of magnesium ethoxide initiator, wherein PPF is specifically designed for us in 3D manufacturing of medical devices. PPF polymers have a number average molecular weight (Mn) of from about 450 Daltons to about 3400 Daltons; a molecular mass distribution (m) of from 1.0 to 2.0; and contains less than 1% w / w of poly(maleic anhydride-co-propylene oxide) polymer chains particularly. PPF polymers are non-toxic, degradable, and resorbable and can be used in tissue scaffolds and medical devices that are implanted within a living organism.

In various embodiments, the invention relates to poly(propylene fumarate) (PPF)-based star-shaped copolymers synthesized using a core-first approach that uses a multi-functional alcohols as an initiator, and Mg(BHT)2(THF)2 as catalyst for controlled ring opening copolymerization (ROCOP) of maleic anhydride (MAn) with propylene oxide (PO). In some embodiments, these star-PPF copolymers have lower viscosities than their linear analogs, allowing a decrease in DEF fraction in resin formulation, as well as the use of higher molecular weights. These star-shape PPF can be used to prepare PPF:DEF resins containing as much as 70% by weight of the multi-arm PPF star copolymers, and have a low complex viscosity of high Mn star PPF resin that affords rapid printing with a Mn nearly eight times larger than the largest linear PPF oligomer printed previously.

The invention discloses a biodegradable unsaturated polyurethane material comprising a soft segment and a hard segment, wherein the soft segment comprises unsaturated polyester polyol polypropylene fumarate, and the hard segment comprises saturated aliphatic isocyanate and a small molecule glycol chain extender or a small molecule diamine chain extender. The material is prepared by taking polypropylene fumarate as large molecule dihydric alcohol, saturated aliphatic isocyanate as a raw material and small molecule glycol or small molecule diamine as a chain extender, and adopting a two-step chain extension method. The polyurethane elastomer namely the biodegradable unsaturated polyurethane material prepared by the preparation method disclosed by the invention has biodegradability, the material and a degradation product are harmless to human bodies, and the material has good biocompatibility. A polyurethane main chain structure comprises a lot of unsaturated electron-deficient double bonds to facilitate further modification of the material, and the material has a good application prospect.

The invention discloses an adenine-reinforced degradable soft tissue adhesive as well as a preparation method and a use method thereof, and the preparation method comprises the following steps: step 1, putting PPF, PPF-DA and Adenine powder into a solvent, and uniformly stirring to obtain a mixture A; step 2, removing the solvent in the mixture A to obtain a mixture B; 3, adding a photoinitiator BAPO solution into the mixture B, and uniformly mixing the materials to obtain a mixture C; and step 4, removing the solvent in the mixture C to obtain the adenine-reinforced degradable soft tissue adhesive. When in use, ultraviolet light is adopted to carry out photocuring on the material. According to the invention, adenine is introduced into a poly propylene fumarate-based material in a dispersive distribution manner, and meanwhile, the bonding performance, degradation performance and biocompatibility of the material are improved. The problems that in the prior art, the adhesion strength between a PPF-based material and soft tissue is low, and application of the PPF-based material to a soft tissue adhesive is limited are solved.

In various embodiments, the present invention is directed to a PPF-based copolymer for 3D printing applications and methods for its making and use. These copolymers have a viscosity in a printable viscosity range and allow light transmittance at curing wavelengths. In various embodiments, a lower viscosity copolymers are obtained by substitution of a portion of maleic anhydride with succinic anhydride and then forming a poly(propylene fumarate-co-succinate) copolymer by the copolymerization of maleic anhydride and succinic anhydride with propylene oxide via Mg(BHT)2(THF)2 catalyzed ring opening copolymerization (ROCOP). Because of their lower viscosities, these copolymers require less, if any, diethyl fumarate (DEF) to prepare the 3D printing resin, while the mechanical properties can still be adjusted as with a PPF polymer prepared without the succinic anhydride.

The invention provides a poly-butyl glycol fumaric acid ester-based material for an environment-friendly LED packaging adhesive and a preparation method of the poly-butyl glycol fumaric acid ester-based material. A final curing product is a PBF / PPF-DA cross-linking solidified body, namely, a poly-butyl glycol fumaric acid ester / poly-butyl glycol fumaric acid ester diacrylic ester cross-linking solidified body, the solidified product is free of toxicity, the solidification time can be controlled within a relatively short time range by adjusting the lighting intensity and the distance between a light source and a sample, the requirements of LED packaging on the solidification time can be greatly met, and the solidified product is relatively good in light transmittance, refractive index, thermal stability and mechanical property.