Adenine-reinforced degradable soft tissue adhesive as well as preparation method and use method thereof

A technology of adenine and soft tissue, applied in the field of adenine-enhanced degradable soft tissue adhesives, which can solve the problems of low adhesion strength and achieve high glass transition temperature, high cohesive strength, and excellent degradation performance

Active Publication Date: 2020-01-14
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of adenine enhanced degradable soft tissue adhesive and its preparation and use method, the present inventi

Method used

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  • Adenine-reinforced degradable soft tissue adhesive as well as preparation method and use method thereof
  • Adenine-reinforced degradable soft tissue adhesive as well as preparation method and use method thereof
  • Adenine-reinforced degradable soft tissue adhesive as well as preparation method and use method thereof

Examples

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preparation example Construction

[0047] The specific preparation process includes the following steps:

[0048] Step 1. PPF and PPF-DA are accurately weighed with a double bond ratio of 1:2 and placed in a round bottom flask containing 20mL-25mL dichloromethane.

[0049] Step 2. Add adenine whose mass proportion is 1%-7% of the total mass of PPF, PPF-DA and adenine into the mixed system obtained in step 1, and stir for 0.5h with a magnetic stirrer to completely dissolve PPF and PPF-DA , Adenine is diffusely distributed, and mixture A is obtained.

[0050] Step 3. Rotary evaporation to remove the dichloromethane solvent in the mixture A under vacuum conditions. Rotary evaporation time is 0.67h-0.75h, temperature is 30℃-35℃, vacuum degree is not higher than 0.09MPa, and mixture B is obtained. During rotary evaporation, the temperature is gradually increased from 30℃ to 35℃.

[0051] Step 4, adding a photoinitiator BAPO solution with a mass proportion of 1.5% of the total mass of the mixture B to the mixture B. Under ...

Embodiment 1

[0058] The double bond ratio of PPF and PPF-DA is 1:2, mass ratio is 1:2.08, 0.48g PPF is accurately weighed, and 1g PPF-DA is placed in a round bottom flask containing 20 mL of dichloromethane. Use an analytical balance to weigh 0.0149g of adenine and place it in the above-mentioned PPF and PPF-DA mixed system (the mass of adenine in this example is 1% of the total mass of PPF, PPF-DA and adenine), and place the round bottom flask In a magnetic stirrer, stir at 400r / min for 0.5h to completely dissolve PPF and PPF-DA, and adenine is dispersed in the mixed solution. Under the vacuum condition not higher than 0.09MPa, set the temperature of the water bath of the rotary evaporator to 30°C, keep it for 13 minutes, raise it to 33°C, keep it for 13 minutes, and finally raise it to 35°C, keep it for 14 minutes, and rotate it for a total of The dichloromethane solvent was removed for 0.67h. Using a pipette, pipette 224 μL of the 0.1g / mL photoinitiator BAPO solution into the above roun...

Embodiment 2

[0060] The double bond ratio of PPF and PPF-DA is 1:2, mass ratio is 1:2.08, 0.48g PPF is accurately weighed, and 1g PPF-DA is placed in a round bottom flask containing 20 mL of dichloromethane. Use an analytical balance to weigh 0.0458g of adenine and place it in the above-mentioned PPF and PPF-DA mixed system (the mass of adenine in this example is 3% of the total mass of PPF, PPF-DA and adenine), and place the round bottom flask In a magnetic stirrer, stir at 400r / min for 0.5h to completely dissolve PPF and PPF-DA, and adenine is dispersed in the mixed solution. Under the vacuum condition not higher than 0.09MPa, set the temperature of the water bath of the rotary evaporator to 30°C, keep it for 13 minutes, raise it to 33°C, keep it for 13 minutes, and finally raise it to 35°C, keep it for 14 minutes, and rotate it for a total of The dichloromethane solvent was removed for 0.67h. Using a pipette, pipette 229 μL of the 0.1 g / mL photoinitiator BAPO solution into the above rou...

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Abstract

The invention discloses an adenine-reinforced degradable soft tissue adhesive as well as a preparation method and a use method thereof, and the preparation method comprises the following steps: step 1, putting PPF, PPF-DA and Adenine powder into a solvent, and uniformly stirring to obtain a mixture A; step 2, removing the solvent in the mixture A to obtain a mixture B; 3, adding a photoinitiator BAPO solution into the mixture B, and uniformly mixing the materials to obtain a mixture C; and step 4, removing the solvent in the mixture C to obtain the adenine-reinforced degradable soft tissue adhesive. When in use, ultraviolet light is adopted to carry out photocuring on the material. According to the invention, adenine is introduced into a poly propylene fumarate-based material in a dispersive distribution manner, and meanwhile, the bonding performance, degradation performance and biocompatibility of the material are improved. The problems that in the prior art, the adhesion strength between a PPF-based material and soft tissue is low, and application of the PPF-based material to a soft tissue adhesive is limited are solved.

Description

Technical field [0001] The invention belongs to the technical field of medical soft tissue adhesives, and in particular relates to an adenine-enhanced degradable soft tissue adhesive and preparation and use methods thereof. Background technique [0002] Compared with traditional surgical suture sutures, the emergence of medical adhesives has brought the wound closure method to a new level. It not only has ordinary adhesive properties, but also has specific biomedical functions, which can be fundamentally improved treatment effect. After decades of research, various types of medical soft tissue adhesives, such as fibrin adhesives, BioGlue, cyanoacrylate adhesives, GRF adhesives, etc., have been used clinically, but they are still sticky. Different disadvantages such as insufficient bonding strength, risk of carrying viruses, poor degradation performance, and toxic degradation products have restricted the further development of clinical applications of various soft tissue adhesive...

Claims

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Application Information

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IPC IPC(8): A61L24/06A61L24/00C08F299/04
CPCA61L24/0042A61L24/06C08F299/0428C08F299/0492C08L55/005
Inventor 郭大刚魏婷
Owner XI AN JIAOTONG UNIV
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