Absorbable cervical intervertebral fusion cage and preparation method thereof

Abstract

The invention discloses an absorbable cervical intervertebral fusion cage and a preparation method thereof. The fusion cage is a bionic intervertebral fusion cage made from nano-hydroxyapatite and poly propylene fumarate polymer composites; the preparation method of the fusion cage comprises the steps that a PPF/DEF mixed solution is prepared in proportion, BAPO is added, then the nano-hydroxyapatite is added, the prepared mixed solution is injected into a fusion cage polymethyl methacrylate mould, and is prepared into a fusion cage prototype after ultraviolet irradiation polymerization, and finally punching and teeth making are carried out on the fusion cage prototype. The fusion cage has bone induction activity and absorbability in vivo, can be degraded in vivo gradually until the humanbody adsorbs the fusion cage completely, the fusion situation after surgery can be observed through X ray, and the fusion cage is applied to anterior cervical intervertebral fusion fixed cases. The absorbable cervical intervertebral fusion cage and the preparation method thereof have the advantages that the preparation method is simple, a better interface combination between inorganic components and high polymer materials can be ensured, the mechanical strength of the prepared polymer is higher than that of a thermo-crosslinking method, and the mechanical strength and elasticity modulus of thepolymer are more close to cancellous bone of the human body.

Description

technical field [0001] The invention belongs to the medical field and relates to a medical operation implant, in particular to an absorbable cervical intervertebral fusion device and a preparation method thereof. Background technique [0002] Cervical spondylosis is a variety of symptoms and signs caused by degenerative changes of cervical intervertebral discs and its secondary pathological changes that stimulate or compress adjacent tissues. It is a common and frequently-occurring disease that plagues office workers in today's society. As the disease progresses, it can lead to serious consequences such as long-term pain, nerve compression, and even paralysis. Patients who do not respond to conservative treatment usually require intervertebral fusion surgery. Commonly used bone graft materials for intervertebral fusion include autologous bone, allogeneic bone, and cage-assisted bone graft. Autologous bone is limited, and there are complications in the bone harvesting area,...

AI Technical Summary

Problems solved by technology

Among them, metal cages have little clinical application due to the large difference in elastic modulus and human cancellous bone, and have the disadvantage of being radiopaque; carbon fiber cages have basically stopped clinical application because of the greater harm of carbo...

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