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Novel crosslinkable and degradable multi-block copolymer, preparation method and application thereof

A multi-block copolymer, a new type of technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of unknown impact of filler on the biocompatibility of main material, many factors affecting performance, uncontrollable process, etc. The effect of unrestricted three-dimensional structure, wide application range and simple molding process

Active Publication Date: 2021-01-05
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the performance regulation method of polymer biomaterials is mainly: adding specific "fillers" to the main material to control the various properties of the blend. This method has many factors affecting the performance, the process is uncontrollable, and the filler has a great influence on the main material. Intrinsic biocompatibility effects unknown

Method used

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  • Novel crosslinkable and degradable multi-block copolymer, preparation method and application thereof
  • Novel crosslinkable and degradable multi-block copolymer, preparation method and application thereof
  • Novel crosslinkable and degradable multi-block copolymer, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Embodiment 1 Preparation of novel photocrosslinkable degradable multi-block copolymer

[0062] A preparation method of a novel photocrosslinkable degradable multi-block copolymer, the synthesis process is as follows figure 1 shown, including the following steps:

[0063] 1) Synthesis of polytrimethylene carbonate (PTMC): 50g of TMC monomer and 2.8g of diethylene glycol (diethyleneglycol) were placed in a vacuum oven at 50°C and vacuum 2 ) and 3 mL of anhydrous toluene; seal the polymerization bottle and vacuumize for 2 days to remove the toluene and water, then place it in an oil bath at 130°C for 3 days, add 100 mL of dichloromethane to dissolve the polymerization bottle after quenching, and then dissolve in 1L of petroleum ether The precipitation was repeated three times, and vacuum drying was performed to obtain polytrimethylene carbonate (PTMC2k) with a number average molecular weight of 2000 (Mn=2000).

[0064] 2) Synthesis of polytrimethylene fumarate (PPF): 50g ...

Embodiment 2～12

[0066] Embodiment 2~12 preparation of novel photocrosslinking degradable multi-block copolymer

[0067] The preparation method of novel photocrosslinkable degradable multi-block copolymer among the embodiment 2~12 is identical with embodiment 1, and difference is only in the synthetic reaction time of PPF (i.e. fumarate bis(hydroxypropyl) ester adds vacuum and heats up after The polycondensation time), the number average molecular weight of PTMC and the PTMC feed ratio (that is, the ratio of PTMC quality to the sum of PTMC and PPF mass), as shown in Table 1.

[0068] Differences between the preparation method of the novel photocrosslinkable degradable multi-block copolymer in Examples 2-12 of Table 1 and Example 1

[0069]

[0070]

[0071] NOTE: The number average molecular weight of PTMC is controlled by the monomer to initiator molar ratio.

Embodiment 13

[0073] Synthesis of polytrimethylene fumarate (PPF): 50g diethyl fumarate (diethyl fumarate) and 65.97g 1,2-propanediol (1,2-propandiol) were added to the three-necked flask successively, under nitrogen atmosphere ( Flow rate: 3~5 bubbles per second) Stirring at 150rpm for 20min, then adding 0.39g of zinc chloride (ZnCl 2 ) mixed with 0.064g hydroquinone; stirred at 100°C and stirred at 300rpm for 30min and then heated up to 150°C for 7h and then cooled to 100°C (first step reaction) to obtain di(hydroxypropyl) fumarate ( bis (hydroxypropyl) fumarate); apply vacuum, react at 100°C for 1 hour, then raise the temperature to 130°C for 7 hours (the second step reaction), and obtain PPF.

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Abstract

The invention relates to the technical field of high polymer material synthesis, and discloses a novel crosslinkable and degradable multi-block copolymer, the chemical structural formula of which is shown as formula (I) in the specification, wherein in the formula (I), n is greater than or equal to 3 and less than or equal to 22; m+p is greater than or equal to 4 and less than or equal to 110; andm, n and p are positive integers. The preparation method of the novel crosslinkable and degradable multi-block copolymer comprises the following steps of: uniformly mixing polypropylene fumarate andpoly(trimethylene carbonate), and carrying out reaction at 150-170DEG C for 4-6h to obtain the copolymer. The physical, chemical and degradation properties of the novel crosslinkable and degradable multi-block copolymer provided by the invention can be adjusted by changing the molecular weights and component ratios of PPF and PTMC; oxidation-reduction or ultraviolet crosslinking curing molding canbe carried out, and the performance of a finally molded product can be flexibly regulated and controlled by regulating and controlling a polymer crosslinking network. The copolymer can be used as a tissue engineering material for bone, cartilage and nerve regeneration.

Description

technical field [0001] The invention belongs to the technical field of polymer material synthesis, and in particular relates to a novel crosslinkable and degradable multi-block copolymer and its preparation method and application. Background technique [0002] The development of biomedical science has led to the urgent need for various biomaterials and advanced manufacturing methods, and has gradually increased the complexity of biomedical applications such as tissue engineering, which are all affected by the biomaterials used. For example, tissue engineering requires biomaterials with sufficient and appropriate mechanical properties for various applications such as hard and soft tissue replacement. For a specific tissue or organ, the scaffold material needs to have matching mechanical properties to achieve a certain supporting effect, especially for some tissues that require high mechanical properties (such as bone and cartilage tissue). When the mechanical properties of t...

Claims

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Application Information

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IPC IPC(8): C08G81/02A61L27/58A61L27/50A61L27/18
CPCC08G81/027A61L27/58A61L27/50A61L27/18A61L2430/02A61L2430/06A61L2430/32
Inventor 王山峰成肖鹏利文杰全大萍
Owner SUN YAT SEN UNIV
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