Preparation method of high-compatibility magnesium-based biocomposite material

A composite material and compatibility technology, applied in the field of magnesium alloy materials, can solve the problems that the compatibility of magnesium alloy materials cannot effectively meet the performance of implant materials, so as to enhance free energy and hydrophilicity, and reduce tensile stress , Improve the effect of compatibility performance

Inactive Publication Date: 2018-06-29
王建东
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] The technical problem to be solved by the present invention: Aiming at the problem that the compatibility of existing magnesium alloy materials cannot effectively meet the performance of implant materials, a preparation method of a highly compatible magnesium-based biocomposite material is provided

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  • Preparation method of high-compatibility magnesium-based biocomposite material

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Embodiment Construction

[0022] In terms of parts by weight, weigh 10-15 parts of polytrimethylene fumarate, 10-15 parts of 200-mesh hydroxyapatite, 6-8 parts of N-methylpyrrolidone, and 1-2 parts of benzoyl peroxide , 3 to 5 parts of sodium chloride and 45 to 50 parts of 1,4-dioxane were placed in a three-necked flask, stirred and mixed and ultrasonically dispersed at 200 to 300W for 10 to 15 minutes, and then exchanged at 75 to 80°C After 3-5 hours of reaction, the cross-linking solution is obtained and the volume ratio is 1:1. The cross-linking solution and deionized water are stirred and mixed to obtain a mixed solution, and the mixed solution is placed at 55-60°C and rotated to evaporate to the volume of the mixed solution. 1 / 5 of 2-methacryloyloxyethylphosphorylcholine, 3-5 parts of methyl Add n-butyl acrylate, 1 to 2 parts of azobisisobutyronitrile and 45 to 50 parts of methanol, stir and mix and place in a water bath at 55 to 65°C for 15 to 20 hours to obtain a reaction solution with a volume ...

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Abstract

The invention relates to a preparation method of a high-compatibility magnesium-based biocomposite material, and belongs to the technical field of magnesium alloy materials. According to the method, poly (propylene fumarate) is used as a raw material and as a coating porous gel to modify the surface of a magnesium alloy material. Since the porous gel is used as a carrier, a network gel structure can be effectively formed, cell adsorption specific surface area is enlarged, and a large number of cells can be accommodated, so that the carrier has a high cell capacity, and the porous structure effectively adsorbs phosphorylcholine. The phosphorylcholine is used for surface modification to significantly enhance the surface free energy and hydrophilicity of the magnesium alloy material and effectively improve the compatibility of the magnesium-based biomaterial with the cells.

Description

technical field [0001] The invention relates to a preparation method of a highly compatible magnesium-based biocomposite material, belonging to the technical field of magnesium alloy materials. Background technique [0002] With the development of society, technology and medicine, the research and development of biomaterials has attracted extensive attention from the academic community. As an important part of biomaterials, biomaterials implanted into hard tissues have become a hot spot in development and research. Metal materials, ceramic materials and organic polymer materials have all been applied in artificial hard tissue materials, but these materials have certain limitations. The mechanical properties of organic polymer materials such as polylactic acid are usually low, and it is difficult to bear large loads, while the toughness of ceramic materials is poor. Metal and alloy materials have high mechanical strength, elasticity, and processing properties, and they domi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/34A61L27/28A61L27/52A61L27/56A61L27/50C25D11/30
CPCA61L27/047A61L27/28A61L27/34A61L27/50A61L27/52A61L27/56A61L2400/18A61L2420/02A61L2420/06A61L2430/02C25D11/024C25D11/026C25D11/30C08L67/06
Inventor 王建东蒋益
Owner 王建东
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