Medicinal composition for haemofiltration or hemodialysis

A technology of blood filtration and medicine, which is applied in the direction of drug combination, active ingredients of anhydride/acid/halide, active ingredient of alkali/alkaline earth metal chloride, etc. It can solve problems such as unstable ion concentration control and cumbersome preparation procedures

Inactive Publication Date: 2009-02-18
BEIJING XINDONG LIANCHUANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above process is prone to unstable ion concentration control, and the disadvantages of cumbersome preparation procedures

Method used

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  • Medicinal composition for haemofiltration or hemodialysis
  • Medicinal composition for haemofiltration or hemodialysis
  • Medicinal composition for haemofiltration or hemodialysis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0018] 1. Two compartments or packs

[0019] Combination example 1:

[0020] Part A: Sodium lactate (sodium citrate, sodium malate, sodium tartrate, or sodium succinate), sodium chloride, magnesium chloride, and calcium chloride.

[0021] Part B: Sodium bicarbonate.

[0022] Combination example 2:

[0023] Part A: Sodium Chloride, Magnesium Chloride and Calcium Chloride.

[0024] Part B: Sodium lactate (sodium citrate, sodium malate, sodium tartrate, or sodium succinate) and sodium bicarbonate.

[0025] Combination example 3:

[0026]Part A: Magnesium Chloride and Calcium Chloride.

[0027] Part B: Sodium chloride, sodium lactate (sodium citrate, sodium malate, sodium tartrate, or sodium succinate) and sodium bicarbonate.

[0028] Combination example 4

[0029] Part A: Calcium Chloride.

[0030] Part B: Magnesium chloride, sodium chloride, sodium lactate (sodium citrate, sodium malate, sodium tartrate, or sodium succinate) and sodium bicarbonate.

[0031] 2. Three com...

Embodiment 1

[0053] Embodiment 1 Preparation of hemofiltration or dialysis solution of the present invention

[0054] The components used in the hemofiltration or dialysis fluid of the present invention are all in compliance with GMP regulations, and are prepared by blending the components with injection water. After screening and filtering steps known in the art, they are respectively filled into appropriate containers and sterilized. The formula of hemofiltration or dialysate of the present invention is as follows:

[0055] Recipe Example 1

[0056] Ingredient Content (mg / ml)

[0057] Sodium Lactate 0.90

[0058] Sodium chloride 5.90

[0059] Magnesium chloride·6H 2 O 0.20

[0060] Calcium chloride·2H 2 O 0.18

[0061] Sodium bicarbonate 2.69

[0062] Recipe Example 2

[0063]

[0064] Recipe Example 3

[0065]

[0066] Recipe Example 4

[0067]

[0068] Recipe Example 5

[0069]

Embodiment 2

[0070] Embodiment 2 Preparation of medical packaging containing hemofiltration or dialysis fluid of the present invention

[0071] The ingredients in the following replenishment solutions A and B were blended with water for injection to form the supplement solutions A and B respectively. After screening and filtering steps known in the art, they are respectively filled into different compartments or packages of a medical container. The container is sterilized and forms the hemofiltration / dialysate product of the present invention. Add supplement B to supplement A at an appropriate time and mix uniformly to form the hemofiltration / dialysate of the present invention.

[0072] 1. Formulation Example 1

[0073] Divide the ingredients in the above formula example 1 into parts A and B and prepare them as follows:

[0074] 5L Supplement A and 200mL Supplement B

[0075]

[0076] after mixing Each ion / root concentration (mM) equivalent concentration (mEq) ...

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PUM

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Abstract

The invention relates to a hemofiltration or hemodialysis solution. The compositions of the hemofiltration or hemodialysis solution are sodium salt or sodium salt hydrate, magnesium salt or magnesium salt hydrate, calcium salt or calcium salt hydrate and organic acid salt or organic acid salt hydrate, wherein the arithmetic product (Ksp) of the solubility of organic acid ions and calcium ions is more than 6X10<-9>(25 DEG C). The invention also provides a medicinal product, which comprises at least two compartments or independent packages; and the compositions of the hemofiltration or hemodialysis solution are respectively arranged in the compartments or the packages by means of different combinations, wherein the compartments contain the calcium salt or the packages do not contain carbonate.

Description

technical field [0001] The present invention relates to a hemofiltration or dialysis solution which is not easy to precipitate and is easy to use and a medical product for storing the hemofiltration or dialysis solution of the invention. Background technique [0002] Hemodialysis is a phenomenon in which molecules in the blood and dialysate at both ends of the semipermeable membrane freely diffuse with each other through the difference in concentration, which is called dialysis. Through the semi-permeable membrane, the uremic molecules in the blood can be taken out of the body through the dialysate. If negative pressure or high-osmotic substances such as high-concentration glucose are added to the dialysate, a large amount of water in the blood will be moved into the dialysate and taken away from the human body. This effect is called ultrafiltration (ultrafiltration) . [0003] Hemodialysis uses diffusion and ultrafiltration to remove uremic molecules, but hemofiltration r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/185A61K33/14A61P43/00
Inventor 柯文哲邱奕明陈静宜
Owner BEIJING XINDONG LIANCHUANG BIOTECH
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