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Fat emulsion dialysate as well as preparation method and application thereof

A technology of milk dialysate and fat emulsion, which is applied in the field of hemodialysis and can solve the problems of human albumin source and treatment cost limitation

Active Publication Date: 2022-07-08
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although albumin dialysis can effectively remove water-soluble toxins and protein-bound toxoids, correct the internal environment disorder of patients, and improve clinical symptoms, its clinical application is limited by the source of human albumin and the cost of treatment.

Method used

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  • Fat emulsion dialysate as well as preparation method and application thereof
  • Fat emulsion dialysate as well as preparation method and application thereof
  • Fat emulsion dialysate as well as preparation method and application thereof

Examples

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preparation example Construction

[0038] The second aspect of the present invention provides the preparation method of the fat emulsion dialysate provided by the first aspect of the present invention. On the basis of the known formula of the fat emulsion dialysate, those skilled in the art can select a suitable method to prepare the above fat emulsion dialysate. For example, it may include providing an oil phase and an aqueous phase, mixing and homogenizing the oil phase and the aqueous phase to provide a fat emulsion dialysate. For another example, when mixing and / or homogenizing, the temperature of the system may be 50-90°C, 50-60°C, 60-70°C, 70-80°C, or 80-90°C. For another example, the oil phase and the water phase can be fully mixed by high-speed shearing. 10~20min, 5~10min, 10~12min, 12~14min, 14~16min, 16~18min, 18~20min, 20~25min, or 25~30min. As another example, the homogeneous pressure conditions are 200-1000 bar, 200-400 bar, 400-600 bar, 600-800 bar, or 800-1000 bar. For another example, the homo...

Embodiment 1

[0056] The aqueous and oil phases were prepared separately. Weigh 5.5g soybean oil, 4.5g medium chain triglyceride and 0.15g α-tocopherol, mix and stir to fully dissolve them as oil phase; weigh 0.13g sodium oleate, 0.9g glycerol and a certain mass fraction (0.4, 0.8 , 1, 2 and 3%) egg yolk lecithin was added to a certain volume of solution (water or dialysate), stirred and dispersed uniformly as the water phase. The oil phase is pretreated by high speed shearing. After the temperature of the water phase was raised to 70 °C, the oil phase was slowly injected into the water phase, and sheared for 10 min under the condition of high-speed shearing at a certain speed. The sheared solution is subjected to gradient homogenization (600, 800, 1000, 2 times per gradient) using a high-pressure homogenizer under a pressure of 600-1000 bar to obtain a fat emulsion dialysate. When the fat emulsion dialysate is used for in vitro simulated dialysis, it needs to be used with 5% sodium bicar...

Embodiment 2

[0058] Malvern particle size analyzer was used to detect the hydration kinetic size of the fat emulsion in the fat emulsion dialysate with different phospholipid contents prepared according to the method described in Example 1. The results are shown in Table 1. The transmission electron microscope was used to observe the fat emulsion with 3% phospholipid content. The surface morphology of the particles, the results are as figure 1 shown. The apparent morphology (stability) of the fat emulsion during standing at room temperature for 21 days is as follows figure 2 As indicated (wherein, A. Day 1; B. Day 4; C. Day 7; D. Day 14).

[0059] Table 1 Different phospholipid content fat emulsion particle size

[0060]

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Abstract

The invention relates to the field of hemodialysis, in particular to fat emulsion dialysate as well as a preparation method and application thereof. The invention provides a fat emulsion dialysate. The fat emulsion dialysate comprises long-chain fat emulsion oil, medium-chain triglyceride, an antioxidant, sodium oleate, glycerin, phospholipid and a solvent. Compared with traditional dialysis, the fat emulsion dialysate provided by the invention has a better clearing advantage on protein binding toxoid. Besides, the fat emulsion dialysate not only is simple in preparation method and low in cost, but also has good stability and safety, keeps stable for 14 days at room temperature, does not have obvious precipitates, can become a novel hemodialysate with wide application prospects, and has good industrialization prospects.

Description

technical field [0001] The invention relates to the field of hemodialysis, in particular to a fat emulsion dialysate and a preparation method and application thereof. Background technique [0002] Protein-bound toxoids refer to toxins that are mostly present in a bound form in plasma and accumulate due to abnormal metabolism under pathological conditions. Due to the low free levels of protein-bound toxoids in the blood, protein-bound toxins cannot pass through the dialysis membrane and are therefore difficult to remove by conventional hemodialysis techniques. The accumulation of uremic protein-binding toxins (PBUTs) in patients with end-stage renal disease is associated with an increased incidence of uremic complications. It is closely related to the increased incidence of mortality and cardiovascular disease. The removal of uremic PBUTs is a difficult problem in blood purification technology. PBUTs are usually small-molecule organic anions, among which the organic anions...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/44A61K47/14A61K47/10A61K47/24A61K47/06A61K47/22A61P7/08
CPCA61K9/107A61K47/44A61K47/14A61K47/10A61K47/24A61K47/06A61K47/22A61P7/08
Inventor 丁峰王宜峰沈毓琪
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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