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Compound amino acid hemodialysis concentrate

A compound amino acid, hemodialysis technology, applied in the field of hemodialysis preparations, can solve the problems of accelerated protein decomposition, reduced protein synthesis, malnutrition in patients, etc., to reduce blood phosphorus, improve symptoms, and promote the entry of serum phosphorus into cells. Effect

Inactive Publication Date: 2017-12-12
SHANDONG WEIGAO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hemodialysis is an important means for patients with chronic renal failure to maintain survival. It can remove toxins, correct salt metabolism disorders and acid-base imbalances, but long-term hemodialysis can aggravate amino acid metabolism disorders. Studies have proved that amino acids and peptides are lost every time hemodialysis It is about 10-13g. The lack of amino acids in the patient's body, especially the essential amino acids and conditional essential amino acids, leads to a decrease in protein synthesis in the body, accelerated protein decomposition in the body, and malnutrition in the patient, which leads to malnutrition in the patient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Compound amino acid hemodialysis concentrate powder

[0023] Take 0.175-0.98g of alanine, 0.175g-1.75g ​​of arginine, 0.175g-0.98g of glycine,

[0024] Histidine 0.175g~1.75g, Isoleucine 0.175g~1.75g, Leucine 0.175g~1.75g,

[0025] Lysine hydrochloride 0.175g~1.75g, methionine 0.175g~1.75g, phenylalanine 0.175g~1.75g,

[0026] Proline 0.175g~1.75g, Serine 0.175g~1.75g, Threonine 0.175g~1.75g,

[0027] Tryptophan 0.07g~1.4g, Tyrosine 0.035g~1.4g, Valine 0.175g~2.1g,

[0028] Sodium chloride 204.5-235g, calcium chloride 6.02g~8.42g, magnesium chloride 1.78g~7.12g, potassium chloride 2.61g~10.44g,

[0029] Glucose 0-140g / L, glacial acetic acid, citric acid, lactic acid, malic acid 0-1.5-33.6g.

Embodiment 2

[0031] Compound amino acid hemodialysis concentrate powder

[0032] Agent A: Weigh 0.175g of alanine, 0.175g of arginine, 0.175g~0.98g of glycine,

[0033] Histidine 1.75g, Isoleucine 1.75g, Leucine 1.75g,

[0034] Lysine hydrochloride 1.0g, methionine 0.5g, phenylalanine 0.5g,

[0035] Proline 1.0g, Serine 0.4g, Threonine 1.25g,

[0036] Tryptophan 1.1g, Tyrosine 0.2g, Valine 1.6g,

[0037] Sodium chloride 204.5g, calcium chloride 6.5g, magnesium chloride 2.5g, potassium chloride 3.3g, glacial acetic acid 8.4g

[0038] Agent B: take 84g of sodium bicarbonate, pack

Embodiment 3

[0040] Compound amino acid hemodialysis concentrate powder

[0041] Agent A: Take 0.2g of alanine, 0.5g of arginine, 0.45g of glycine,

[0042] Histidine 0.175g, Isoleucine 0.175g, Leucine 0.175g,

[0043] Lysine Hydrochloride 1.75g, Methionine 1.75g, Phenylalanine 1.75g,

[0044] Proline 0.8g, Serine 1.5g, Threonine 0.9g,

[0045]Tryptophan 0.14g, Tyrosine 0.7g, Valine 1.3g,

[0046] Sodium chloride 210g, calcium chloride 6.02g, magnesium chloride 3.56g, potassium chloride 5.0g, glucose 35g, citric acid 8g are mixed evenly, packed

[0047] Agent B: Sodium bicarbonate 70g

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PUM

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Abstract

The invention provides a compound amino acid hemodialysis concentrate. The compound amino acid hemodialysis concentrate comprises, by weight, 5-50 parts of arginine, 5-50 parts of histidine, 5-50 parts of isoleucine, 5-50 parts of lysine hydrochloride, 5-50 parts of methionine, 5-50 parts of phenylalanine, 5-50 of threonine, 2-40 parts of tryptophan and 5-60 parts of valine, and further comprises 20-50 of leucine, 5-28 parts of alanine, 5-28 parts of glycine, 35-40 parts of tyrosine, 5-10 parts of serine and 28-50 parts of proline. The invention further provides a compound amino acid hemodialysis solution and a preparation method thereof. The hemodialysis solution can effectively reduce the occurrence of hypertension during hemodialysis, relaxation of vascular smooth muscle and vasodilation can be avoided, and the incidence of hypertension can be decreased.

Description

technical field [0001] The invention relates to a compound amino acid hemodialysis concentrate. The invention relates to a compound amino acid hemodialysis concentrate for hemodialysis, which is used for patients with chronic renal failure, especially for hemodialysis patients with malnutrition, a preparation for hemodialysis supplemented with amino acid nutrition in the form of hemodialysis fluid and its preparation process method. Background technique [0002] In chronic renal insufficiency, protein intake needs to be restricted, and endocrine dysfunction leads to abnormal amino acid metabolism. Hemodialysis is an important means for patients with chronic renal failure to maintain survival. It can remove toxins, correct salt metabolism disorders and acid-base imbalances, but long-term hemodialysis can aggravate amino acid metabolism disorders. Studies have proved that amino acids and peptides are lost every time hemodialysis It is about 10-13g, and the lack of amino acid...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K33/06A61K31/4172A61P7/08A61K31/405A61K31/401A61K31/198A61K31/195A61K31/7004
CPCA61K31/195A61K31/198A61K31/401A61K31/405A61K31/4172A61K31/7004A61K33/06A61K33/14A61K2300/00
Inventor 杜武华黄显峰林栋青吴明杰
Owner SHANDONG WEIGAO PHARM CO LTD
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