Injectable water-proof calcium phosphate bone cement

Abstract

The invention provides a'waterproofing injectable calcium phosphate bone cement' which is an injectable bioactive bone cement and a bone graft substitute material, and consists of two parts, namely a solid-phase part comprising calcium carbonate, alfa-tricalcium phosphate and dicalcium phosphate, and a liquid-phase part comprising sodium triphosphate and hydroxypropylmethyl cellulose. The waterproofing injectable calcium phosphate bone cement can be used by only mixing and stirring the solid-phase part and the liquid-phase part evenly in the proportion, and has three advantages: (1) the waterproofing injectable calcium phosphate bone cement cures at a normal temperature to generate hydroxyapatite which has the same inorganic ingredients in human bone; (2) the waterproofing injectable calcium phosphate bone cement has better injection performance and can be injected to a bone defect area via minimal invasive percutaneous injection with a slimmer entry needle; and (3) the waterproofing injectable calcium phosphate bone cement has perfect water-proof performance and can be applied to the blood environment without affecting the curing process of the bone cement.

Description

Technical field [0001] The invention is an injectable biologically active bone cement, which can be injected percutaneously to fill bone defects, and is a substitute material for bone grafting. Background technique [0002] Currently, commonly used bone graft materials include autologous bone, allogeneic bone, hydroxyapatite, ceramics, and coral. Because these materials are solid, a long pruning process is required to adapt to the shape of the bone defect for filling, and a large incision exposure is required to fill the bone defect with the bone graft material, which makes minimally invasive treatment impossible. More traumatic. Calcium phosphate cement (CPC) family materials are a new type of bone graft material that has emerged in recent years. It is composed of solid phase powder and liquid phase aqueous solution. Mix the solid phase and liquid phase in proportion at room temperature Finally, a paste is formed which eventually solidifies to a solid with at least one of...

AI Technical Summary

Problems solved by technology

Calcium phosphate cement can be arbitrarily shaped to fill various shapes of bone defects in the pasty stage. There are dozens of different products, but most formula bone cements have poor fluidity and cannot be injected through a syringe. They can only be used as dough Use, need to expand the wound to fill the bone defect, not suitable for minimally invasive applications

In addition, the waterproof performance of most calcium phosphate cements is not good, that is to say, if the bone cement is applied to the environment with body fluids too early in the pasty stage, the bone cement will be scattered and cracked, and cannot be solidified smoothly.

Images