Injectable water-proof calcium phosphate bone cement

Abstract

The invention provides a'waterproofing injectable calcium phosphate bone cement' which is an injectable bioactive bone cement and a bone graft substitute material, and consists of two parts, namely a solid-phase part comprising calcium carbonate, alfa-tricalcium phosphate and dicalcium phosphate, and a liquid-phase part comprising sodium triphosphate and hydroxypropylmethyl cellulose. The waterproofing injectable calcium phosphate bone cement can be used by only mixing and stirring the solid-phase part and the liquid-phase part evenly in the proportion, and has three advantages: (1) the waterproofing injectable calcium phosphate bone cement cures at a normal temperature to generate hydroxyapatite which has the same inorganic ingredients in human bone; (2) the waterproofing injectable calcium phosphate bone cement has better injection performance and can be injected to a bone defect area via minimal invasive percutaneous injection with a slimmer entry needle; and (3) the waterproofing injectable calcium phosphate bone cement has perfect water-proof performance and can be applied to the blood environment without affecting the curing process of the bone cement.

Description

Technical field

[0001] The invention is an injectable biologically active bone cement, which can be injected percutaneously to fill bone defects, and is a substitute material for bone grafting. Background technique

[0002] Currently, commonly used bone graft materials include autologous bone, allogeneic bone, hydroxyapatite, ceramics, and coral. Because these materials are solid, a long pruning process is required to adapt to the shape of the bone defect for filling, and a large incision exposure is required to fill the bone defect with the bone graft material, which makes minimally invasive treatment impossible. More traumatic. Calcium phosphate cement (CPC) family materials are a new type of bone graft material that has emerged in recent years. It is composed of solid phase powder and liquid phase aqueous solution. Mix the solid phase and liquid phase in proportion at room temperature Finally, a paste is formed which eventually solidifies to a solid with at least one of...

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