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Medicaments composite for treating gland hyperplasia and breast cancer and preparation method thereof

A technique for mammary gland hyperplasia and composition, which is applied to traditional Chinese medicine compositions and substances for treating breast disease and preparation thereof, granules for breast cancer and preparation thereof, and the field of treating mammary gland hyperplasia, which can solve the problem of unreasonable preparation process and limiting curative effect of drug prescriptions, etc. question

Active Publication Date: 2011-06-22
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent document with the application number CN200610114397.2 "Chinese medicine composition for treating breast diseases and its preparation method" discloses a medicine that can nourish kidney deficiency, warm kidney yang, activate blood circulation and remove stasis, soften hard masses and treat breast cancer and hyperplasia of mammary glands Composition and substance, but its preparation process is unreasonable, which limits the efficacy of drug prescriptions

Method used

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  • Medicaments composite for treating gland hyperplasia and breast cancer and preparation method thereof
  • Medicaments composite for treating gland hyperplasia and breast cancer and preparation method thereof
  • Medicaments composite for treating gland hyperplasia and breast cancer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0024] Experimental example 1. Optimum experiment of the extraction process of the traditional Chinese medicine group and substance of the present invention

[0025] 1. Test materials

[0026] Agilent1100 high performance liquid chromatograph, including G1311A quaternary gradient pump, G1313A autosampler, G1315A diode array detector (HP, USA); Lambda 25UV / VIS spectrometer (PerkinElmer, USA); AG285 analytical balance (Mettler, Germany) Company); KS-600D ultrasonic cleaning machine (Ningbo Kesheng Instrument Factory); 98-1-B electronic thermostat heating mantle (Tianjin Test Instrument Co., Ltd.). 5-Hydroxymethylfurfural reference substance (batch number: 111626-200402), purchased from the National Institute for the Control of Pharmaceutical and Biological Products, acetonitrile chromatographically pure, and the rest of the reagents are analytical pure.

[0027] 2. Methods and results

[0028] 2.1 Determination of 5-hydroxymethylfurfural content by HPLC

[0029] 2.1.1 Chromatographic co...

experiment example 2

[0050] Experimental example 2. Screening of auxiliary materials in the preparation of capsules and granules of the present invention

[0051] The extract of the present invention contains more hygroscopic substances such as mucus and lipopolysaccharide, and the solid preparation of the product obtained is easy to absorb moisture during storage, which makes the product quality unstable; in addition, in order to make the product content accurate and convenient to take, The appropriate excipients are selected according to the hygroscopicity, moldability, melting properties, bulk density and angle of repose of the granules after mixing the excipients with the extract powder. Experimental method: Take 43.8g of comfrey, 175g of rehmannia, 45.8g of aconite (manufactured), 58.3g of corydalis, 58.3g of cinnamon, and extract and concentrate the medicinal materials according to the optimal extraction process. 43.7g of comfrey, Gourd 175g, turtle shell 87.5g, and scorpion 35g are crushed int...

experiment example 3

[0097] Experimental example 3. Preparation of the tablet of the present invention

[0098] Take one-half of the prescription amount of the above comfrey, pulverize melon, turtle, and scorpion into fine powder to obtain the fine powder of medicine for use; the other medicinal flavors are decocted in water, combined with the decoction, concentrated into an extract, mixed with the above fine powder , Then mix with 0.5-5% sodium carboxymethyl starch to obtain a drug mixture; after deerhorn gum is added to the above mixture, it is made into granules, dried, granulated, compressed, and coated to obtain .

[0099] The disintegration of the tablets made by the present invention is not good, so we screened the added disintegrants through experiments. The test results are as follows: Table 12: Table 12 Experimental results of different disintegrants made into tablets

[0100] Disintegrant

[0101] Therefore, the present invention selects sodium carboxymethyl starch as the disintegrant.

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Abstract

The invention provides a traditional Chinese medicine component for treating breast hyperplasia and breast cancer and a preparation method thereof. Pharmaceutical raw materials of the pharmaceutical component are composed of: sinkiang arnebia root, radix rehmanniae preparata, common monkshood daughter root (prepared), yanhusuo, cassia bark, snakegourd fruit, turtle shell, scorpion and deer horn gelatine; the preparation method is as follows: part of the weight parts of sinkiang arnebia root, snakegourd fruit, turtle shell and scorpion are smashed into fine powder, the smashed powder is ready for use; the residual sinkiang arnebia root, radix rehmanniae preparata, common monkshood daughter root (prepared), yanhusuo, cassia bark and deer horn gelatine are decocted by adding water, decocted liquid is merged and concentrated to the relative density of 1.28 to 1.30, the smashed powder and excipients are added for even mixing, and the deer horn gelatine is added in the mixture after meltingby heat, thereby preparing various preparations which are needed clinically.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine composition for treating breast diseases and a preparation method thereof, in particular to a granule for treating breast hyperplasia and breast cancer and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Breast disease is a common, frequently-occurring disease in women, and it is difficult to cure for a long time. The incidence rate is as high as 80%. The incidence of breast hyperplasia has reached more than 60% of women of childbearing age. In recent years, breast disease is at its peak and the rate of canceration is relatively high. According to the latest data from the epidemiological statistics of the China Traditional Chinese Medicine Breast Disease Prevention and Research Center, the incidence of breast cancer in women has increased by 39% in recent years, and the age of onset has been 10 years earlier. Age, tending t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61K9/16A61K9/20A61K9/48A61P15/14A61P35/00A61K35/32A61K35/56A61K35/64A61K35/586A61K35/646
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD