Ginsenoside Rb1 containing impurity ginsenoside Rc

Abstract

The invention discloses a standard ginsenoside Rb1 active ingredient, containing ginsenoside Rb1 with the content more than or equal to 90% and less than 100%, is also characterized in that the active ingredient contains ginsenoside Rc with the content more than 0% and less than or equal to 10%; or the content of impurity ginsenoside Rc is more than or equal to 0.05% and less than or equal to 6.5%; or the content of ginsenoside Rc is more than or equal to 0.1% and less than or equal to 5.0%; the content of impurity ginsenoside Rc is more than or equal to 0.1% and less than or equal to 3.0%; Pharmacological experiments show that the standard active ingredient of the application has good pharmacological effects and can be prepared into pharmaceutical preparations in Pharmacy.

Description

Technical field [0001] The present invention relates to the technical field of traditional Chinese medicine, in particular to a standard ginsenoside Rb 1 Active ingredients. [0002] The present invention is to provide a standard active ingredient of traditional Chinese medicine, namely standard ginsenoside Rb containing impurity ginsenoside Rc 1 . Background technique [0003] The application of traditional Chinese medicine has a history of thousands of years and has made a significant contribution to human health. With the increasing use of traditional Chinese medicine, the safety of traditional Chinese medicine has attracted worldwide attention. Due to the particularity of traditional Chinese medicine (such as Complex ingredients, more ingredients, etc.), it is difficult to carry out the monitoring of adverse reactions of traditional Chinese medicine. However, for the health of the majority of patients, the monitoring of adverse reactions will definitely be greatly strengthene...

AI Technical Summary

Problems solved by technology

[0005] Ginsenoside Rb 1 A small amount (mg level to g level) is mostly obtained by laboratory methods, such as preparation of high performance liquid chromatography, silica gel column chromatography, etc., for scientific research, but it is impossible to obtain batches (above kg level) of ginsenoside Rb 1 It is used for the development and industrial production of finished medicine, so this is ginsenoside Rb 1 Reasons and Difficulties of Difficult Medicine So far

[0006] Application No. 03127664.4 patent document "environmental protection type ginsenoside Rb 1 High yield industrial separation", this document discloses that ginsenoside Rb with a content greater than 95% can be obtained 1 , using silica gel column chromatography, the method is expensive and difficult to industrialized production; another major problem in this document is that there is no method for analysis and detection to show that ginsenoside Rb 1 The content reaches 95%, and its credibility is doubtful; the patent document "Ginsenoside Rb" with application number 03148803.x 1 The preparation technology of ", this document discloses the method for adopting macroporous resin method+silica gel column chromatography+silica gel column chromatography to obtain ginsenoside Rb 1 , the same method is only applicable to laboratory research, and is difficult to realize industrial production; another major problem of this document is to obtain ginsenoside Rb 1 There is no purity, and there is no method for content determination; the patent document "A Method for Extracting and Separating Ginsenoside Monomers from Ginseng Leaves" with application number "200610093610.6" discloses the method of using macroporous resin method + silica gel column chromatography. Method for separating and obtaining different ginsenoside monomers, including ginsenoside Rb 1 ; Its main problem still does not have the requirement of purity, does not have assay method, and this technological method has still adopted column chromatography this complex, cost height, the method that can't industrialized production

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